ABSTRACT
Parkinson's disease combined with thyroid dysfunction is not uncommon in clinical practice.Due to similarities and overlaps between their symptoms and an unclear cause-and-effect relationship, the diagnosis and treatment may be missed and delayed.Here we summarize the clinical manifestations of the two diseases and analyze the potential pathogenic mechanisms shared between them, in order to provide a reference for the understanding of their pathogenesis and for the treatment of Parkinson's disease.
ABSTRACT
The theory of amyloid-induced Alzheimer's disease(AD) has been challenged by the scientific community.However,with the deep study of amyloid beta(Aβ)cascade metabolic reaction process and the characteristics and functions of various Aβ polypeptides,people have a profound understanding of the pathogenesis of AD caused by Aβ.Currently,several Aβ antibodies,including the protofibril selective antibody BAN2401,are in clinical trials for treating Alzheimer's disease.After the good results of targeted therapy for Aβ(Ban2401),this theory has attracted our attention again.In this paper,the pathogenesis of Aβ and the progress of targeted therapy were reviewed systematically.
ABSTRACT
The theory of amyloid-induced Alzheimer's disease(AD)has been challenged by the scientific community.However, with the deep study of amyloid beta(Aβ)cascade metabolic reaction process and the characteristics and functions of various Aβ polypeptides, people have a profound understanding of the pathogenesis of AD caused by Aβ.Currently, several Aβ antibodies, including the protofibril selective antibody BAN2401, are in clinical trials for treating Alzheimer's disease.After the good results of targeted therapy for Aβ(Ban2401), this theory has attracted our attention again.In this paper, the pathogenesis of Aβ and the progress of targeted therapy were reviewed systematically.