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Objective@#The study aimed to investigate the diurnal variation in cervical disc hydration and its relationship with cervical degeneration. @*Materials and Methods@#C3–C7 discs of 86 prospectively enrolled participants (37 males, 49 females; mean age ± standard deviation, 23.5 ± 2.5 years) were assessed using T2 mapping in the morning and evening. All discs were stratified by Miyazaki grade or C2–C7 Cobb angle and T2 values (T2). The degree of diurnal T2 variation (T2-DDV), defined as (morning T2 – evening T2)/morning T2 x 100%, was measured for the entire disc, annulus fibrosus (AF), nucleus pulposus (NP), and endplate zones. @*Results@#T2 of the entire disc decreased significantly after the daytime load (p < 0.001), with a T2-DDV of 13.3% for all discs and 16.0%, 12.2%, and 13.0% for healthy (grade I), mild degenerative (grade II), and advanced degenerative (grade III/IV) discs, respectively. T2 of regional NPs and AFs decreased significantly from morning to evening (p ≤ 0.049) except in the healthy anterior inner AF (p = 0.092). Compared with healthy discs, mild degenerative discs displayed lower T2 and T2-DDV in regional NPs (p < 0.001). Advanced degenerative discs showed higher T2-DDV in the anterior inner AF compared with healthy discs (p = 0.050). Significant diurnal T2 changes in the endplate zones were observed only in healthy discs (p = 0.013). Cervical discs in the low Cobb angle group showed higher T2-DDV in the anterior AFs and anterior NP and lower T2-DDV in the posterior AF than those in the high Cobb angle group (p ≤ 0.041). @*Conclusion@#This study characterized the diurnal variation in hydration of the cervical discs as assessed using T2 mapping and revealed early chemo-mechanical coupling dysfunction in degenerating discs. Cervical sagittal alignment on MRI can affect the diurnal stress patterns of the cervical discs. T2 mapping is sensitive to disc biomechanical dysfunction and offers translational potential from biomechanical research to clinical application.
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Corona virus disease 2019 (COVID-19), which broke out in Wuhan, HuBei in December, 2019, spread around the country in a short term. Some infected patients suffered from severe acute respiratory syndrome. It has become a major public health event of international concern. COVID-19 patients are the main source of transmission and most people get infection easily, so the current main prevention method is interrupting the pathway of transmission. The dental treatments are very special because these operations produce substantial aerosols and lead a high risk of cross-infection, which brings challenge for epidemic prevention and control. In this paper, the characteristics of aerosols and prevention methods of aerosol transmission in dental clinics are mainly discussed.
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Objectives:To analyze the impact of extended myectomy on reducing mitral regurgitation in patients with hypertrophic obstructive cardiomyopathy (HOCM). Methods:We retrospectively analyzed 480 consecutive HOCM patients who underwent surgical treatment by the same surgeon in our institution from October 2002 to July 2017. The efficacy of extended myectomy for reducing mitral regurgitation and left ventricular outflow tract (LVOT) obstruction were evaluated by echocardiography after surgery. Results:Among the 480 patients, 22 (4.6%) received concomitant mitral repair or replacement because of their intrinsic mitral diseases. In the remaining 458 (95.4%) patients without concomitant mitral valve surgery, 1 (0.2%) died at the 5th day after surgery because of infective shock, and another 4 (0.9%) lost to follow-up, a total of 453 (98.9%) patients underwent echocardiographic follow-up (median follow-up time:6 months [3, 12]). During follow-up, left ventricular out flow tract gradient was significantly decreased from (89.1±30.6) to (12.8±11.6) mmHg (P＜0.001); the number of patients with systolic anterior motion (SAM) of mitral leaflets decreased from 451(98.5%) to 42 (9.3%) (P＜0.001); 297 (64.8%) patients presented with moderate or severe mitral regurgitation before surgery, which decreased to 14 (3.1%) at follow-up (P＜0.001); the multivariate regression analysis showed that patients with residual SAM were significantly associated with a higher incidence of moderate to severe mitral regurgitation during follow-up (odds ratio 30.334, 95% confidence interval:5.619-163.739, P＜0.001). Conclusions:Extended myectomy, combined with dividing the anomalous links between mitral apparatus and septum, and trimming papillary muscles, yields satisfactory outcomes of relieving LVOT obstruction and reducing mitral regurgitation in most of patients with HOCM. Concomitant mitral valve surgery is rarely required unless the patient have intrinsic mitral valve disease.
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Objective:To explore the correlation between combined detection of serum high sensitive troponin T (hscTnT),homocysteine (Hcy) and high sensitive C reactive protein (hsCRP) and diagnostic positive rates of coro-nary heart disease (CHD).Methods:A total of 95 CHD patients were selected,including 35 cases with stable angina pectoris (SAP),30 cases with unstable angina pectoris (UAP) and 30 cases with acute myocardial infarction (AMI).According to results of coronary angiography,patients were divided into mild stenosis group (n＝31),moderate ste-nosis group (n＝34) and severe stenosis group (n＝30).Another 95 healthy subjects were enrolled as healthy control group.Levels of hscTnT,Hcy and hsCRP were measured and compared among all groups,positive rates of single and combined detection were measured,and correlation among coronary disease severity,serum levels of hscTnT,Hcy,hsCRP and their combined detection were analyzed.Results:Serum levels of hscTnT,Hcy and hsCRP in CHD group were significantly higher than those of healthy control group,P＝0.001 all.Hcy positive rates of UAP and AMI group were significantly higher than that of SAP group (63.33%,70.00% vs.14.29%,P＝0.001 all).There was no significant difference in positive rate of combined detection (91.43%,93.33%,96.67%) among SAP group,UAP group and AMI group ( P＞0.05 all),but all of them were significantly higher than those of single de-tection,P＜0.05 or ＜ 0.01.Positive rates of hscTnT and hsCRP diagnosing SAP were significantly higher than that of Hcy (68.57%,71.43% vs.14.29%,P＝0.001 all).Compared with mild stenosis group,there were signifi-cant rise in serum levels of hscTnT,Hcy and hsCRP in moderate and severe stenosis group,and those of severe ste-nosis group were significantly higher than those of moderate stenosis group (P＝0.001 all).Biviarate Spearman a-nalysis indicated that serum levels of hscTnT,Hcy and hsCRP,their combined detection results were significant pos-itively correlated with coronary disease severity in CHD patients (r＝0.512～0.813,P＜0.01 all).Conclusion:Pos-itive rate of combined detection of serum hscTnT,Hcy and hsCRP is significantly higher than those of single detec-tion in CHD patients.Combined diagnostic result is significant positively correlated with coronary disease severity.
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Objective To evaluate comprehensive therapy in the treatment of keloid effect and the patients' satisfaction.Methods A total of 523 patients with comprehensive treatment,according to the treatment,were divided into group A (surgery combined radiotherapy) and group B (surgery plus corticosteroids),group C (hyperbaric oxygen in combination with radiotherapy),and the therapeutic effect of patients with satisfaction was analyzed.Results Total effective rate of three groups of patients were 69.47％,89.13％,90.32％,respectively.Effective rate in group A was higher than that of group B and group C,there was statistically significant difference between groups A and C (P ＜ 0.05),but no significant difference between the group A and group B (P＞0.05).Difference was statistically significant between three groups of patients' satisfaction,group B better than group A and group C,the difference between group B and C group was statistically significant (P ＜ 0.05).Conclusions Effectiveness of the three combined therapies is obvious,in which radiotherapy plus hyperbaric oxygen is most effective.
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Objective To investigate the immediate effects of lower limb with open chain weight-adding on joint position sense and gait symmetry in stroke patients. Methods From January, 2016 to January, 2017, 39 stroke patients were included. Their joint position sense and gait symmetry were compared before and after weight-adding. The joint position senses of active reproduction of active positioning (ARAP) and passive reproduction of passive positioning (PRPP) were assessed during lower limb straight leg raise. The gait symmetry was also as-sessed and three indexes were recorded including the symmetry of foot rotation angle, step length and percentage of single leg support phase. Results After weight-adding, the position sense of PRPP did not improve (t=0.832, P=0.832), nor of the symmetry of foot rotation an-gle (t=-0.704, P=0.483) and percentage of single leg support phase (t=0.381, P=0.702);the position sense of ARAP improved (t=3.158, P=0.011), as well as the symmetry of step length (t=2.022, P=0.041). Conclusion The lower limb with open chain weight-adding could im-prove the active joint position sense and symmetry of step length.
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Objective: To report the medium-long term survival rates of ventricular septal myectomy for treating the patients with hypertrophic obstructive cardiomyopathy and to analyze the predictive factors affecting the outcomes. Methods: A total of 655 consecutive patients who received ventricular septal myectomy in our hospital from 1984-10 to 2014-12 were retrospectively summarized. The cohort study was conducted with questionnaires by cardiovascular nurses. Result: The operative mortality was 1.4% (9/655). The mean follow-up time was (30.8 ± 30.9, from 3 to 213) months, there were 52/646 (7.9%) patients lost contact and 583 patients having NYHA classification at I or II during that period. The overall survival rates for 1 year, 5-year and 8-year were 98.3%, 90.5% and 88.3% respectively. There were 80 patients suffered from end point events including HCM-related death, heart transplantation, repeated myectomy, permanent pacemaker implantation and re-admission for ischemic stroke, tachyarrhythmia, myocardial ischemia or infarction, congestive heart failure. The end point events free survival rates for 1 year, 5-year and 8-year were 94.2%, 76.7% and 65.9% respectively. Multivariable Cox regression analysis presented that age>50 years (HR=2.16, 95% CI 1.36-3.46,P=0.001) and pre-operative atrial ifbrillation (FA) (HR=2.31, 95% CI 1.35-3.94,P=0.002) were the independent predictors for end point events occurrence. Conclusion: Ventricular septal myectomy may achieve good medium-long term survival rate with less adverse event in patients with hypertrophic obstructive cardiomyopathy. Elder than 50 years of age and with pre-operative FA were the independent predictors for adverse events occurrence.
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Objective: To summarize the mid-term effect of modified extended Morrow procedure in patients with hypertrophic obstructive cardiomyopathy (HOCM) combining sub aortic valve obstruction and mid left ventricular obstruction. Methods: We studied 34 consecutive HOCM patients with sub aortic and midventricular obstruction who received modiifed extended Morrow procedure with extracorporeal circulation in our hospital from 1996-11 to 2015-01. Transthoracic echocardiography was conducted at pre-, post-operation and follow-up period to evaluate the changes of mid-ventricular gradient, subarctic gradient and each heart valve function. Results: The average follow-up time was (25.7 ± 14.9) months, 2 patients lost contact and no death occurred. In rest 32 patients, the mid ventricular gradient decreased from (60.3 ± 29.4) mmHg to (21.0 ± 19.8) mmHg, subaortic valve gradient decreased from (77.9 ± 26.2) mmHg to (11.6 ± 6.5) mmHg, the maximum ventricular septal thickness dropped from (25.2 ± 4.9) mm to (17.9 ± 7.2) mm, left atrial diameter reduced from (41.1 ± 7.8) mm to (37.6 ± 6.4) mm, left ventricular end-diastolic diameter increased from (39.8 ± 5.1) mm to (42.2 ± 4.3) mm, allP<0.05; there were 5 patients without obviously improved mid ventricular gradient because of insufifcient resection of septal myocardium in mid-ventricle. The post-operative NYHA classiifcation was improved,P<0.01, mitral valve regurgitation degree was decreased,P<0.01 and SAM phenomenon was disappeared. Complications included 3 (8.8%) patients of III atrio-ventricular block, 1 (2.9%) patient of re-admission due to poorly healed sternum combining pneumonia Conclusion: Modified extended Morrow procedure may relieve sub aortic valve and mid ventricular obstruction, therefore improve left ventricular diastolic function and prognosis in relevant patients.
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Objective To evaluate clinical results of endoscopic vein harvesting(EVH) in patients who underwent coronary artery bypass grafting(CABG).Methods From July 2013 to October 2014,500 patients who underwent isolate CABG in our institution were divided into two groups:EVH group (n =250) and open vein harvesting(OVH) group(n =250).The surgical result and perioperative complications were compared between the two groups.Results The procedures were completed successfully in all the patients in both groups.There was no significant difference existed in the length of the harvested vein and vein injury between the two groups(P ＞ 0.05).Similar results were obtained in the in-hospital mortality.Compared to group OVH,group EVH showed significantly shorter harvesting time,smaller incision,and lower rates of perioperative leg complications (P ＜ 0.01).Group EVH had a less bed staying time after operation and a shorter post-operation hospital stay (P ＜ 0.05).EVH group achieved an improved patient satisfaction and postoperative pain when compared with OVH in CABG(P ＜0.05).Conclusion EVH can provide adequate vein graft for CABG,and also significantly reduce wound related complications when compared with OVH.EVH is recommended for vein harvesting to improve patient satisfaction.
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<p><b>OBJECTIVE</b>To establish a rapid and convenient method of DNA modification by bisulfite sodium for the detection of DNA methylation.</p><p><b>METHODS</b>Through increasing the bisulfite sodium concentration and the temperature of treatment, cutting down the modification time, besides using glassmilk to adsorb the DNA in the purification and recovery, to improve the methods of DNA modification. Efficiency of cytosine converted to thymine in MAGE-A3 gene and DAP-K gene fragments were analyzed by bisulfite sequencing PCR in order to evaluate the DNA modification effect among the improved method, traditional method and kit method.</p><p><b>RESULTS</b>The operating time of test was shortened to about 3 hours by the improved method; conversion rate of unmethylated cytosine to thymine was over 99%; compared with the traditional method and kit method, there was no significant difference (χ(2) = 0.0564, P > 0.05); the improved method was only for the unmethylated cytosine conversion modification, and there was no significant difference in process of methylated cytosine converted to thymine comparing with the traditional method (χ(2) = 0.0149, P > 0.05).</p><p><b>CONCLUSION</b>The improved method has high efficiency of DNA modification and has no significant effect on excessive modification;meanwhile, it has many advantages such as time-saving and easy to operate etc.</p>
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Cytosine , Chemistry , DNA , Chemistry , DNA Methylation , Polymerase Chain Reaction , Sulfites , Chemistry , Thymine , ChemistryABSTRACT
The present study aimed at identifying potential lead compounds for diabetes mellitus drug discovery. We developed a novel method involving centrifugal ultrafiltration separation subsequent liquid chromatography with quadrupole time of flight tandem mass spectrometry (LC-Q/TOF-MS/MS) determination to screen α-glucosidase inhibitors in complex Scutellaria baicalensis Georgi (SBG) extract. By adding a second filter to the screening process, the level of non-specific binding of Compounds 1, 3, 10 and 11 was significantly decreased, and the level of non-specific binding of Compounds 5 and 15 also was reduced. As a result, five flavonoids identified as baicalein, baicalein, wogonin, chrysin, and oroxylin A, were rapidly found to interact with α-glucosidase and possess potent anti-α-glucosidase activity in vitro. Specific binding of ligands to α-glucosidase was demonstrated though the proposed method and the ligands could be ranked in order of affinity for α-glucosidase, which were corresponded to the order of inhibitory activity in vitro. In conclusion, our results indicated that the developed method is a rapid and effective screening method for rat intestinal α-glucosidase inhibitors from complex herbal medicines such as SBG.
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Animals , Rats , Chromatography, Liquid , Methods , Flavonoids , Allergy and Immunology , Glycoside Hydrolase Inhibitors , Allergy and Immunology , Hypoglycemic Agents , Allergy and Immunology , Plant Extracts , Chemistry , Tandem Mass Spectrometry , Methods , Ultrafiltration , MethodsABSTRACT
Point Dingchuan (Ex-B1) pertains to extraordinary points and often produces a good therapeutic effect on respiratory system diseases. Ancient Chinese medical books do not record point Dingchuan. Modern Chinese medical textbooks describe the location and efficacy of and indications for this point but do not state their provenances. In order to further popularize the clinical application of point Dingchuan, this article verifies the origin and development of the name and location of point Dingchuan so as to provide a certain reference for clinically correct selection and use of this point. The results show that point Dingchuan followed the course of development from ashi point to new point and then to extraordinary point. The development of point Dingchuan to the same acupoint name and location as now international use went mainly through four stages, that is, similar name and different location, similar name and location, same name and different location, and same name and location.
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<p><b>OBJECTIVE</b>To understand the comorbid characteristics and distribution of combined treatment of Chinese and Western medicine in depressive patients.</p><p><b>METHOD</b>The descriptive statistic method and association rule were used to analyze the data from 19 general hospitals with 3-A level in China.</p><p><b>RESULT</b>Among the depressive disorder, the most frequent co-morbid physical diseases included hypertension (24.67%), coronary heart disease (16.10%) and cerebral infarction (12.89%), and the proportion of comorbid changes with the increasing age, from 6.51% to 12.55%, 16.33% and 12.47% for hypertension; from 2.79% to 5.69%, 10.17% and 14.22% for coronary heart disease; from 3.72%, 6.27%, 7.70% and 12.25% for cerebral infarction. The use frequency of the antidepressants is 77.18%, and the use frequency of flupentixol & melitracen is 20.95%. The use frequency of Huoxue Huayu Tongluo of traditional Chinese medicine is 59.97%, with that of 27.91% for Ginkgo biloba extract The combined use frequency of Huoxue Huayu Tongluo of TCM and the antidepressants is the highest, especially for the combined use of Shuxuening injection and fluoxetine.</p><p><b>CONCLUSION</b>The most frequent comorbid diseases of depression include three kinds of diseases, such as hypertension, coronary heart disease and cerebral infarction, and its proportion gradually increased with the growth of age. The single use frequency of flupentixol & melitracen and G. biloba extract is the highest, while the combined use of Shuxuening injection and fluoxetine is the highest.</p>
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Adolescent , Adult , Aged , Aged, 80 and over , Child , Child, Preschool , Female , Humans , Infant , Infant, Newborn , Male , Middle Aged , Young Adult , Anthracenes , Therapeutic Uses , Antidepressive Agents , Therapeutic Uses , China , Combined Modality Therapy , Methods , Depressive Disorder , Drug Therapy , Drug Combinations , Drugs, Chinese Herbal , Therapeutic Uses , Fluoxetine , Therapeutic Uses , Flupenthixol , Therapeutic Uses , Ginkgo biloba , Chemistry , Medicine, Chinese Traditional , Methods , Plant Extracts , Therapeutic UsesABSTRACT
<p><b>OBJECTIVE</b>To evaluate the change in protein expression of peroxiredoxin I (Prx I) during pulmonary fibrosis among rats exposed to silica dust and to investigate the role of Prx I in pulmonary fibrosis.</p><p><b>METHODS</b>Ninety male Wistar rats were randomly divided into control group (n = 60) and experimental group (n = 30). The control group received intratracheal perfusion of saline (1 ml), while the experimental group received intratracheal perfusion of suspension of silica dust (50 mg/ml) to establish a rat model of silicosis. At 1, 2, 3, 4, 6, or 8 weeks after treatment, 10 rats in control group and 5 rats in experimental group were sacrificed. The lung tissues were collected for conventional pathological observation. The protein expression of Prx I at each time point was measured by immunohistochemistry and Western blot.</p><p><b>RESULTS</b>Among the rats exposed to silica dust, Prx I was seen in the form of brown particles that were mainly distributed in the alveolar septa and the cytoplasm of alveolar epithelial cells, macrophages, vascular endothelial cells, and smooth muscle cells around the blood vessels and tracheae. The control group showed weak protein expression of Prx I, and the experimental group had significantly higher protein expression of Prx I than the control group at all time points (P < 0.05). In the experimental group, the protein expression of Prx I was upregulated significantly at 1 and 2 weeks and decreased at 3∼8 weeks.</p><p><b>CONCLUSION</b>The change in protein expression of Prx I may be one of the important causes of the onset and development of pulmonary fibrosis in rats exposed to free silica.</p>
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Animals , Male , Rats , Disease Models, Animal , Lung , Pathology , Peroxiredoxins , Metabolism , Pulmonary Fibrosis , Pathology , Rats, Wistar , Silicon Dioxide , Toxicity , Silicosis , PathologyABSTRACT
<p><b>OBJECTIVE</b>To study the changes of growth and biofilm formation capability of Enterococcus faecalis (Ef) in different stress conditions.</p><p><b>METHODS</b>The changes of growth of Ef in stress conditions were observed by measuring the A600 value with ultraviolet spectrophotometer. Ef was incubated on glass slide in stress conditions, biofilm formation capability of cells was investigated by colony-forming unit (CFU) counting of the culturable bacteria and fluorescence confocal laser scanning microscopy.</p><p><b>RESULTS</b>Ef couldn't growth under the conditions of 2%, 5%NaClO, pH = 11 and 12, the A600 value was unchanged in 96 hours. But the growth curve changed at different levels in other stress conditions: under 1%NaClO, the A600 value peaked at 1.461 at 16 hour (the peaked level was 1.238 at 6 hours in control group) ; under 0,0.05%,0.15% glucose, it peaked at 0.645,0.890, 1.173, respectively, at 6 hour (it was maximized to 1.195 at 6 hours in control group); the A600 value peaked at 1.704 at 6 hours at pH = 9 and 1.225 at 10 hours at pH = 10 (the peak level was 1.732 at 6 hours at pH = 7) . Biofilm assay showed that Ef were able to form biofilm in these stress conditions except 5%NaClO and pH = 12.</p><p><b>CONCLUSIONS</b>Ef could growth and form biofilms in energy starvation, low concentrations of sodium hypochlorite and weak alkaline stress.</p>
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Biofilms , Colony Count, Microbial , Enterococcus faecalis , Glucose , Pharmacology , Hydrogen-Ion Concentration , Microscopy, Confocal , Sodium Hypochlorite , PharmacologyABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of enriched environment and impoverished environment on the learning and memory ability of manganese-exposed mice and the mechanism.</p><p><b>METHODS</b>Forty female Kunming mice were randomly and equally divided into 4 group: control group (CG), standard environment and manganese exposure group (SEG), enriched environment and manganese exposure group (EEG), and impoverished environment and manganese exposure group (IEG). The mouse model of manganese poisoning was established by intraperitoneal injection of manganese chloride. The learning and memory ability was tested by Morris water maze. The expression of cAMP response element-binding protein (CREB) in area CA1 of the hippocampus was measured by immunohistochemistry.</p><p><b>RESULTS</b>In place navigation test, the SEG had a significantly longer escape latency than the CG (P < 0.05), and the EEG had a significantly shorter escape latency than the SEG (P < 0.05); there was no significant difference in escape latency between IEG and SEG (P > 0.05). In spatial probe test, the EEG had a significantly greater number of platform crossings than the SEG (P < 0.05), and the IEG had a significantly smaller number of platform crossings than the SEG (P < 0.05). The expression of CREB in area CA1 of the hippocampus was significantly lower in IEG and SEG than in CG (P < 0.05), and it was significantly higher in EEG than in SEG (P < 0.05).</p><p><b>CONCLUSION</b>In the enriched environment, the learning and memory ability of manganese-exposed mice can be improved, which may be due to the increased expression of CREB in the hippocampus.</p>
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Animals , Female , Mice , Cyclic AMP Response Element-Binding Protein , Metabolism , Disease Models, Animal , Environment , Hippocampus , Metabolism , Learning , Manganese Poisoning , Metabolism , MemoryABSTRACT
<p><b>OBJECTIVE</b>To assess the efficacy of quick meridian needling therapy plus scalp acupuncture on infantile cerebral palsy (CP).</p><p><b>METHODS</b>One hundred and forty-seven cases of CP were randomly divided into a quick meridian needling therapy plus scalp acupuncture group (group A), a conventional acupuncture group (group B) and a scalp acupuncture group (group C), 49 cases in each one. In group A, quick needling was applied to the Conception Vessel, Governor Vessel, Hand-Yangming, Hand-Jueyin, Foot-Yangming and Foot-Taiyin meridians distributed on four limbs and trunk. One pricking point was 10 mm far from the other one. In scalp acupuncture, motor area, equilibrium area, sensory area, tremor-control area, foot-motor-sensory area, speech No. 2 area, speech No. 3 area, Baihui (GV 20), Sishencong (EX-HN 1), etc. were selected. The needles were stimulated with rotating manipulation and remained for 30-60 min. In group B, the conventional acupuncture was adopted mainly at Dazhui (GV 14), Shenzhu (GV 12), Fengfu (GV 16) and others. In group C, the scalp acupuncture was used and the points selected were same as those in group A for scalp acupuncture treatment. The scores of Gross Motor Function Measure (GMFM) were observed before and after treatment for children. The clinical efficacy of each group was evaluated. By follow-up for 12 months, the condition of independent walking was observed.</p><p><b>RESULTS</b>The total effective rate in group A was 79.6% (39/49), which was superior to that of group B [49.0% (24/49)] and group C [51.0% (25/ 49)] respectively (both P < 0.05). After treatment, GMFM scores of children were all improved significantly in 3 groups (P < 0.001, P < 0.05), of which, the improvement extent in group A was superior to that of other two groups (both P < 0.05). It was found after follow-up for 1 year that 31 cases could walk independently in group A, which was more than group B (17 cases) and group C (16 cases).</p><p><b>CONCLUSION</b>The quick meridian needling therapy plus scalp acupuncture can improve significantly limb motor function of children with cerebral palsy and its therapeutic effect is superior to conventional acupuncture and simple scalp acupuncture.</p>
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Child , Child, Preschool , Female , Humans , Male , Acupuncture Points , Acupuncture Therapy , Cerebral Palsy , Therapeutics , Meridians , Scalp , Treatment OutcomeABSTRACT
<p><b>OBJECTIVE</b>To search for an effective therapy for prolapse of lumbar intervertebral disc of yang deficiency and cold coagulation type.</p><p><b>METHODS</b>One hundred and twenty-six cases were randomly divided into a combined electroacupuncture and Chinese herb group (n=49), an electroacupuncture group (n=42) and a Chinese herb group (n=35). The combined electroacupuncture and Chinese herb group was treated with electroacupuncture at Dachangshu (BL 25), Guanyuanshu (BL 26), Xiaochangshu (BL 27) and Yaoyangguan (GV 3) and oral administration of Chinese herbs for cold-removing and yang-invigorating. The electroacupuncture group was treated with the same electroacupuncture treatment alone and the Chinese herb group with the same self Chinese herbs alone. The therapeutic effects were observed after treatment for 20 days, and the recurrence rates were followed up at 180 days after the last treatment among the three groups.</p><p><b>RESULTS</b>The cured-markedly effective rate was 79.6% in the combined electroacupuncture and Chinese herb group, 54.8% in the electroacupuncture group and 51.4% in the Chinese herb group, the combined electroacupuncture and Chinese herb group being significantly better than both the electroacupuncture group and the Chinese herb group (both P<0.05) and the therapeutic effect of both the electroacupuncture group and the Chinese herb group being similar (P>0.05). The recurrence rate after 180 days was 15.4% in the combined electroacupuncture and Chinese herb group, 83.3% in the electroacupuncture group and 80.0% in the Chinese herb group, with more obvious decrease in the combined electroacupuncture and Chinese herb group (both P<0.01).</p><p><b>CONCLUSION</b>Electroacupuncture combined with Chinese herbs is a better therapy for prolapse of lumbar intervertebral disc of yang deficiency and cold coagulation type.</p>