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This study deeply analyzes the common problems of three military medical universities in the management of undergraduate extracurricular scientific research, such as lack of communication means, limited online resources, backward laboratory opening and low utilization rate of equipment. We have built a cloud platform management system for undergraduate extracurricular scientific research. This system firstly sets up a teaching resources storage module including videos, PPTs, documents, pictures, electronic materials, question bank, etc. Then four subsystems for different roles of students, mentors, experimental teaching staff and administrators are constructed. Finally, this system realizes independent experiments by students, real-time evaluation by mentors, instrument sharing and efficient management through the seamless connection with the user terminal equipment. And the study also makes evaluation on the present usage.
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@#Objective To investigate the expression levels of AChE and BChE in post-stroke dementia （PSD） and its clinical significance. Methods 215 patients with chronic ischemic stroke were admitted to the department of neurology of our hospital from June 2018 to December 2019，64 patients in the PSD group and 151 patients in the post-stroke non dementia （PSND） group according to the degree of cognitive impairment，The non-dementia group was divided into 68 cases of post-stroke non-cognitive impairment （PSNCI） and 83 cases of post-stroke cognitive impairment （PSCI）. General clinical data were collected and serum AChE and BChE levels were detected by enzyme-linked immunosorbent assay （ELISA）；The risk factors affecting PSD was analyzed by Logistic regression analysis；The correlation between serum AChE and BChE levels and the disease，as well as the diagnostic value was performed by pearson correlation analysis and operating characteristic curve （ROC）. Results The age，serum CRP，Hcy and education level of PSD patients were significantly higher than that of PSND patients，and the serum AChE and BchE levels were significantly lower，The differences were statistically significant （P<0.05）；Multivariate Logistic regression analysis showed that age，education level，CRP，Hcy，AChE，and BChE levels were independent risk factors for PSD （P<0.05）；Pearson correlation analysis showed that serum AChE （r=0.457，P<0.001） and BChE level （r=0.421，P<0.001） were significantly positively correlated with MoCA level；In the diagnostic value of serum AChE and BChE levels to PSD，the sensitivity was 85.4% and 87.6%，respectively，and the specificity was 81.2% and 82.3%，respectively，the area under the curve （AUC） was 0.845 and 0.861，respectively. In addition，the combined detection of serum AChE and BChE levels was significantly better than the separate detection of serum AChE and BChE levels （P<0.001）. Conclusion The decrease of serum cholinesterase level is a risk factor for the occurrence of dementia after ischemic stroke，dynamic monitoring of hematological changes is conducive to early diagnosis of PSD patients and active treatment，which has important clinical significance.
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Objective To explore the level of CD62E+ endothelial microparticles in acute cerebral infarction patients and its relationship with vascular risk factors,degree of severity and prognosis.Methods Seventy patients with acute cerebral infarction and 70 non-cerebral infarction patients (controls),admitted to our hospital from January 2013 to September 2013,were selected in our study; U.S.national institutes of health stroke scale (NIHSS) was performed to evaluate the degree of severity; Barthel index (BI) was used to evaluate the prognosis; the levels of blood lipids,blood glucose,uric acid,fibrinogen (FIB),homocysteine (Hcy),C-reactive protein (CRP) and lipoprotein-associated phospholipase A2 (Lp-PLA2) were routinely measured; CD62E+ levels were detected by flow cytometry,and the relationships of CD62E+ level with vascular risk factors,degree of disease and prognosis were analyzed.Results The blood CD62E+ level of patients with acute cerebral infarction ([1.55 ±0.67]microparticle/μL) was significantly higher than that in the control group ([1.01 ±0.66] microparticle/μL,P＜0.05); CD62E+ level in patients with NIHSS scores＞5 ([2.03±0.61] microparticle/μL) was significantly higher than that in patients with NIHSS scores ≤ 5 ([1.25±0.37] microparticle/μL,P＜0.05).Spearman correlation analysis showed that CD62E+ level was significantly correlated with the stroke severity (NHISS scores,r=0.537,P=0.000) and lipoprotein-associated phospholipase A2 (Lp-PLA2) level (r=0.327,P=0.006),and negatively correlated with prognosis indicator (r=-0.634,P=0.000); other factors showed no significant correlation.Conclusion CD62E+ microparticle can reflect the severity and prognosis of acute brain infarction,and it may be an important biological marker for clinical application.Besides,the correlation between Lp-PLA2 and CD62E+ means that the level ofCD62E+ micro particles is associated with the stability of athemsclerotic plaques.
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Objective To evaluate the clinical effect of endovascular stent placement to the treatment of intracranial internal carotid artery dissection.Methods Two patients with intracranial internal carotid artery dissection received the treatment of stent placement,and 1 patient with a dissection of the supra clinoid internal carotid artery received conventional anticoagulation treatment.Results Two patients with intracranial internal carotid artery dissection were given treatment of Apollo stent placement,of which 1 patient had improvement of left limb paresis,the score of NIHSS from 3 before operation to 2 after operation; the other one with episodic left limb weakness was not seen any attack after stent placement.Another one patient without stent placement receiving conventional anticoagulation treatment had some improvement of right limb paralysis.Conclusion The treatment of endovascular stent placement to the intracranial internal carotid artery dissection has better clinical efficacy and especially used for those patients with no effect to the conventional anticoagulation treatment.