1.
Mem. Inst. Oswaldo Cruz
; 87(supl.3): 85-9, 1992. ilus
Article
in English
| LILACS
| ID: lil-121080
ABSTRACT
Many lines of Plasmodium falciparum undrgo a deletion of the right end of chromosome 9 during in vitro culture accompanied by loss of cytoadherence and gametocytogenesis. Selection of cytoadherent cells from a mixed population co-selects for those with an undeleted chromosome 9 and selected cells produce gametocytes. The deletion also results in loss of expression of PfEMP1, the putative cytoadherence ligand, suggesting PfEMP1 or a regulatory gene controlling PfEMP1 expression and gametocytogenesis may be encoded in this region. We have isolated several markers for the deleted region and are currently using a YAC-P. falciparum library to investigate this region of the genome in detail
Subject(s)
Chromosome Deletion , Erythrocyte Membrane , Plasmodium falciparum/ultrastructure
2.
Mem. Inst. Oswaldo Cruz
; 81(supl.2): 63-68, 1986. ilus, graf
Article
in English
| LILACS
| ID: lil-623803