1.
Biol. Res
; 26(1/2): 273-7, 1993. tab
Article
in English
| LILACS
| ID: lil-228625
ABSTRACT
Molecular expression cloning techniques revealed that patients with the severest clinical form of Chagas disease, chronic Chagas heart disease, presented a strong humoral response against the cloned C-terminal portion of a Trypanosoma cruzi ribosomal P protein. Parasite P antigens identification led to characterize the ribosomal P protein system in T. cruzi. Their exposed location on the ribosome, and the ®amplification® of their parasite specific, serine free C-terminal domain, generate a strong parasite specific anti-P response, that in certain cases may induce anti-P autoimmunity
Subject(s)
Animals , Humans , Antigens, Protozoan/immunology , Autoimmunity , Chagas Disease/immunology , Protozoan Proteins/immunology , Ribosomal Proteins/immunology , Trypanosoma cruzi/immunology , Amino Acid Sequence , Chronic Disease , Epitopes/immunology , Molecular Sequence Data
2.
Mem. Inst. Oswaldo Cruz
; 85(4): 539-43, Oct.-Dec. 1990.
Article
in English
| LILACS
| ID: lil-127800