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Objective To explore the factors of relapse in alcohol-induced psychiatric and behavioral disorders.Methods103 male inpatients met with the diagnostic criteria of alcohol-induced psychiatric and behavioral disorders according to ICD-10 were enrolled.All patients were hospitalized from Wuxi Mental Center from January 2013 to August 2015.As baseline,information was obtained within all patients,and relapse was evaluated one year after discharge.The Kaplan-Meier method was used to statistically analyze the alcohol relapse time of patients with different length of hospitalization.Cox regression was used to explore the risk factors for alcohol relapse,including age,education level,marital status,family history,smoking,fixed income,number of hospitalizations,duration of alcohol intake,average daily alcohol intake,time of psychosis,psychiatric symptoms,length of hospitalization,physical condition and mental condition.Results(1)The analysis (log rank) showed that the length of hospitalization had no significant statistical differences with relapse(χ2=0.069,P=0.966).(2) The number of hospitalizations (RR=1.074,95%CI=1.002-1.151,P=0.042) and average daily alcohol intake(RR=1.035,95%CI=1.012-1.059,P=0.003) were the risk factors for relapse.ConclusionThe number of hospitalizations and average daily alcohol intake are risk factors for relapse within a year in male inpatients with alcohol-induced psychiatric and behavioral disorders.Prolonged hospital stay has no help to reduce relapse in those people.
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Objective To investigate the effects of 17-methoxyl-7-hydroxy-benzene-furabcgakcone( MHBFC ) on isoproterenol-induced ventricular remodeling in mice. Methods Isoproterenol(ISO)was given subcutaneously(1 mg·kg-1, twice per day for 7 d)to induce ventricular remodeling in mice. Mice were divided into normal control group,model group, captopril group,MHBFC low and high-dose groups. 65 mg·kg-1 captopril was given by intragastric administration in captopril group,2. 5,5. 0 mg·kg-1 MHBFC were given by intravenous injection in MHBFC low and high-dose groups. At the end of the 7th day,the hearts of the mice were weighted,and myocardial hypertrophy index was expressed as heart weight/body weight, double kidneys weight/body weight and lung weight/body weight( HW/BW,KW/BW and LW/BW). Colorimetric method was used to determine the content of hydroxyproline( Hyp)in heart,the activity of superoxide dismutase( SOD)and the content of malondialdehyde( MDA)in serum. The histological changes were observed by HE and Masson’s staining,the changes of cross section area( CSA),collagen volume fraction,( CVF)and perivascular circumferential collagen area( PVCA)were determined. Results Compared with the model group,MHBFC potently inhibited cardiomyocyte hypertrophy,decreased the HW/BW, KW/BW and LW/BW,improved cardiac pathology changed,increased the of activity SOD,decreased the content of MDA in serum and the content of Hyp in heart tissue(P﹤0. 01 or P﹤0. 05),decreased the CVF and PVCA(P﹤0. 01). Conclusion MHBFC possesses protective effects against ISO-induced ventricular remodeling in mice,which may be related to its actions in reducing the oxidative stress and improving the antioxidant activity of the body.
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Objective To evaluate efficacy of healthy canteen based-nutritional health promotion so as to provide evidence for popularization and application.Methods A total of 429 college professors and administrative staffs with a healthy canteen were selected as the intervention group in 2012 in Changzhou,and another 947 counterparts without a healthy canteen were selected as the control group.Those of the intervention group was further assigned to the ≥2 times/week and＜2 times/week subgroups.Blood pressure,fatty liver,serum triglycerides,blood glucose,total cholesterol,uric acid,low-density lipoprotein cholesterol,high-density lipoprotein cholesterol and body mass index(BMI)were tested before and after the intervention.Results After the intervention,the mean serum glucose[(5.06±0.62)mmol/L],uric acid[(310.57 ± 71.79)μmol/L],total cholesterol[(4.88 ± 0.86)mmol/L],triglycerides[(1.39 ± 0.67)mmol/L]and low-density lipoprotein cholesterol[(2.51 ±0.62)mmol/L]of the intervention group were significantly decreased(t values were 7.513,2.126,2.062,3.731 and 8.891,respectively; all P＜0.05),and mean high-density lipoprotein cholesterol[(1.43±0.34)mmol/L]were significantly increased(t=-2.309,P＜0.05).After the intervention,mean serum glucose and uric acid of the control group were significantly increased(t values were-3.491 and-7.703,respectively; both P＜0.05),although there was no statistically significant difference of mean serum triglycerides,total cholesterol,low-density lipoprotein cholesterol and high-density lipoprotein cholesterol in the control group before and after the intervention(all P＞0.05).The abnormality rates of serum glucose,uric acid,total cholesterol,triglycerides,low-density lipoprotein cholesterol and BMI as well as the incidence of hypertension of the intervention group were significantly decreased after the intervention(x2 values were 4.202,3.940,4.031,7.305,59.422,4.273 and 7.385,respectively; P＜0.05).In the control group,although the abnormality rate of serum uric acid and the incidence of fatty liver were significantly inclined after the intervention(x2 values were 23.740 and 7.408,respectively; both P＜0.05),there were no significant difference of abnormal serum triglycerides,glucose,total cholesterol,low-density lipoprotein cholesterol and BMI as well as the incidence of hypertension before and after the intervention(all P＞0.05).Mean serum triglycerides[(1.15 ±0.68)mmol/L]and low-density lipoprotein cholesterol[(2.4 1±0.60)mmol/L]in the ≥2 times/ week subgroup were significantly lower than those of the＜2 times/week subgroup(t values were-4.884 and-2.513,respectively; both P＜0.05),and mean high-density lipoprotein cholesterol[(1.46±0.33)mmo]/L]of the ≥2 times/week subgroup was significantly higher than that of the＜2 times/week subgroup(t=2.032,P＜0.05).The abnormality rates of serum total cholesterol,triglyceride and low-density lipoprotein cholesterol in the ≥ 2 times/week subgroup were significantly lower than those in the＜2 times/week subgroup(x2 values were 3.963,9.947 and 4.589,respectively; all P＜0.05).Conclusion Healthy canteen based-nutritional health promotion model may provide an effective method to prevent and control the development of noncommunicable chronic diseases.
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Formaldehyde is a chemical which is traditionally used as disinfectant and preservative. Recently,formaldehyde becomes raw material of adhesive which is widely used for indoor decoration. It has been recently reported in many animal experiments that formaldehyde had adverse effects on male reproductive endocrine,sperm quantity and quality,and but few reports were obtained about the adverse effects of formaldehyde on male reproductive system in human beings. Damage to genetic material,induced by lipid peroxidation and cell apoptosis is the possible mechanism of toxic effect. Male reproductive toxicity and mechanism of formaldehyde were discussed,and the recent researches were reviewed in the present paper.
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The present article reviews the advances in the studies of male reproductive toxicity of the pesticides that are widely used and commonly researched in the recent years by means of animal experiment and human investigation. The mechanism of male reproductive toxicity of pesticides is discussed. And problems are raised in the evaluation of human reproductive hazards.
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Animals , Humans , Male , Follicle Stimulating Hormone , Blood , Genitalia, Male , Luteinizing Hormone , Blood , Pesticides , Toxicity , SpermatozoaABSTRACT
To explore the feasibility of the application of LD 1 laser dust monitor to determination of inhalable particulates(IP) in indoor air of public places, and provide basis for establishment of national standard method of detection of IP in indoor air of public places LD 1 laser dust monitor and weighing filter paper method were applied in monitoring the concentration of IP in indoor air of 4 kinds of public places in Changzhou in four seasons simultaneously Significant correlation was observed between mass concentration and relative concentration ( r =0 7526, P
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Objective To understand the sanitary status of the air conditioning system of public places and to discuss the countermeasure.Methods Fifty public places where the air conditioning system were used were selected as the research objects in September 2008.The questionnaires about the hygienic management, the air conditioning system and the cooling tower were used to investigate the basic situations of the air conditioning system in public places,and Legionella pneumophila(Lp) of cooling water in the cooling tower was detected.Results All the fifty public places didn't establish complete sanitary management system.90% of the cooling towers were less than one kilometer from the residential areas, schools, kindergartens, agedness flats and hospitals.And 18% of the cooling towers were less than one hundred meters from the walking streets and entertainment plaza.Moreover,8% of the public places had not fresh air, the air purification wasn't installed in 74% of the public places and sterilization equipments, and automatic or on-line sterilization equipments in the cooling towers weren't installed in all the public places.In addition, the positive rate of Legionella pneumophila in the cooling towers was 89.58%.Thereinto, the positive rate of Lp1 type(79.07%) of Legionella pneumophila was significantly higher than that of Lp2-Lp14 type(11.63%) as well as that of Lp1 type and Lp2-Lp14 type(9.30%)(P0.05).Conclusion The air conditioning systems of public places are being faced with some sanitary problems and the cooling water in the cooling tower was polluted with Legionella pneumophila.Therefore,it is suggested that its sanitary management should be reinforced and the sterilization management of cooling water as well as the shield between the cooling towers and the circumferences should be taken into account.