Effect of vitamin-E on high fat diet induced hyperlipidemia in rats.

High fat diet intake in rats resulted in hyperlipidemia which was evidenced by elevated levels of plasma cholesterol, free fatty acids, triglycerides and increased LDLc/HDLc ratio. Vitamin E (400 mg/kg body wt/day) administration for 60 days prevented the elevations in plasma lipid levels. It reduced LDLc/HDLc ratio, lipid peroxide levels and elevated the level of reduced glutathione (GSH) in hyperlipidemic rats. Vitamin-E was non-toxic.