Psychosocial interventions for patients with alcohol use disorder: A systematic review / 한국간호교육학회지

Purpose@#The aims of this study were to identify the psychosocial interventions for patients with alcohol use disorder and to assess the effects of those interventions. @*Methods@#A systematic literature search was conducted using PubMed, the Cochrane Library, Embase, CINAHL, PsycINFO, KoreaMed, KMBASE, RISS, KISS, Science ON, and DBpia to identify studies reported in English or Korean from 2012 to 2021. @*Results@#From the 4,051 studies extracted, 14 studies were selected for review. The majority of the psychosocial interventions were focused on cognitive therapy or cognitive-behavior therapy. Most of the studies reported that the interventions made positive effects on alcohol consumptions. In addition, the psychosocial interventions for patients with alcohol use disorder were effective on coping, support, alcohol avoidance behavior, and hostility bias. Most of the studies reporting positive effects of psychosocial intervention programs applied computers, mobile phones, or similar electronic devices. @*Conclusion@#The findings of this systematic review suggest that the use of computers or mobile devices in psychosocial intervention programs will be effective. It can be said that this systematic review reflects the current trends involving the development of information and communication technology. This systematic review can provide basic data for establishing evidence and suggesting future directions for psychosocial interventions for patients with alcohol use disorder.

Relationships of Serum Iron Parameters and Hemoglobin with Forced Expiratory Volume in 1 Second in Patients with Chronic Obstructive Pulmonary Disease / 가정의학회지

BACKGROUND: Although chronic obstructive pulmonary disease is a known cause of secondary polycythemia with elevated erythropoietic demands in response to hypoxemia, anemia is relatively common in patients with chronic obstructive pulmonary disease and is related to increased mortality. However, little is currently known about the relationship between various iron parameters and disease severity in chronic obstructive pulmonary disease patients. METHODS: Data from the fifth Korean National Health and Nutrition Examination Survey, a population-based epidemiologic survey conducted in 2010–2012, were used. A total of 1,129 patients with chronic obstructive pulmonary disease were examined to reveal the associations between the forced expiratory volume in 1 second (FEV1) and hemoglobin and iron parameters, including serum iron, ferritin, total iron binding capacity, and transferrin saturation, using Spearman correlations and multiple linear regression analyses. RESULTS: The FEV1 was positively correlated with serum hemoglobin (γ=0.37, P < 0.001), iron (γ=0.20, P < 0.001), transferrin saturation (γ=0.19, P < 0.001), and ferritin (γ=0.22, P < 0.001), and negatively correlated with age (γ=−0.40, P < 0.001) and lower in female patients (γ=−0.56, P < 0.001) in the Spearman correlation. The FEV1 was independently associated with serum iron (β=0.049, P=0.035) and transferrin saturation (β=0.049, P=0.035) after adjusting for age, sex, and body mass index in the multiple linear regression analyses. CONCLUSION: The serum iron and transferrin saturation levels were independently associated with FEV1 as a marker of chronic obstructive pulmonary disease severity.

Topical application of herbal formula for the treatment of ligature-induced periodontitis

PURPOSE: The aim of this study was to investigate the therapeutic effects of a herbal formula, PerioH-035, containing Angelica sinensis, steamed Rehmannia glutinosa, Angelica dahurica, Cimicifuga heracleifolia, and Zanthoxylum piperitum on the periodontal breakdown in a well-established ligature-induced periodontitis model in rats. METHODS: Sprague-Dawley rats were randomly assigned to 1 of 4 groups: NL (non-ligatured), L (ligatured), P1 (ligatured and treated with 1 mg/mL PerioH-035), P100 (ligatured and treated with 100 mg/mL PerioH-035). Periodontitis was induced by placing a ligature around the mandibular first molars. PerioH-035 was topically applied to both sides of the first molar for 2 weeks. The right side of the mandibles was retrieved for micro-computed tomography (CT) and methylene blue staining to analyze alveolar bone loss. The left side of the mandibles was histologically analyzed by TRAP and H&E staining. The MMP-9 mRNA level in gingival tissue was investigated by RT-PCR. RESULTS: Alveolar bone resorption was significantly reduced in the PerioH-035-treated groups. The number of dense multi-nucleated cells found to be TRAP-positive by staining in the ligatured rats was markedly decreased by PerioH-035 application. In addition, periodontal tissue destruction, especially cementum demineralization, was ameliorated in the P1 and P100 groups. Moreover, gingival tissue from the PerioH-035-treated group showed a decrease in the MMP-9 mRNA level, resulting in recovery of collagen degradation. CONCLUSIONS: These results suggest that PerioH-035 has therapeutic effects on periodontitis, and thus, PerioH-035 shows promise as a treatment for periodontitis. GRAPHICAL ABSTRACT:

A Case of Alveolar Adenoma Involving Multiple Lung Nodules / 대한내과학회지

Alveolar adenoma is a very rare benign intraparenchymal lung tumor originating from type II pneumocytes. It can be mistaken for other benign tumors or lung cancer in radiological images. It is especially difficult to distinguish alveolar adenoma from sclerosing hemangioma. A small aspiration biopsy specimen, such as with percutaneous needle aspiration, is insufficient for a pathological diagnosis. Surgical resection is the only method by which a pathological diagnosis can be made and the disease treated. An alveolar adenoma presenting as multiple nodules is very rare and has to our knowledge not been reported in Korea previously. Here, we report a case of alveolar adenoma in multiple nodules in a 57-year-old female and review the literature.

Sensory education program development, application and its therapeutic effect in children

There has recently been Increased interest in the emotional intelligence (EQ) of elementary school students, which is recognized as a more important value than IQ (intelligence quotient) for predict of their success in school or later life. However, there are few sensory education programs, available to improve the EQ of elementary school student's in Korea. This study was conducted to develop an educational program that reflects the characteristics and contents of traditional rice culture and verify the effects of those programs on the EQ of children. The program was developed based on the ADDIE (Analysis, Design, Development, Implementation and Evaluation) model and participants were elementary school students in 3rd and 4th grade (n = 120) in Cheonan, Korea. Descriptive statistics and paired t-tests were used. EQ scores pertaining to the basic sense group, culture group, and food group were significantly improved after the sensory educational program(P < 0.05), but no change was observed in the control group. These findings indicate that sensory education contributed to improving elementary school children's Emotional Intelligence (EI) and their actual understanding about Korean traditional rice culture.

Systemic capillary leak syndrome (Clarkson's disease) during elective pylorus-preserving pancreaticoduodenectomy: case report

Systemic capillary leak syndrome (SCLS), also called Clarkson's disease is rare and life-threatening disorder of unknown etiology, which is a characteristic triad of hypovolemic shock, hemoconcentration, and hypoalbuminemia. Unexplained capillary leakage from the intravascular to the interstitial space, which has been estimated up to 70% of the intravascular volume, is the proposed mechanism. Because the pathogenesis is unknown, it is diagnosed clinically after exclusion of other diseases that cause systemic capillary leak and no efficacious pharmacological treatment has been clearly established. The mortality rate ranges from 30% to 76%. In Korea, four cases of SCLS (5 cases in adult and 1 case in child) were reported by 2012. We describe a case of severe SCLS that suddenly occurred and rapidly progressed during pylorus preserving pancreaticoduodenectomy and review the literature.

Clinical Usefulness of Combined Anti-tuberculosis Antibody Test and Interferon-gamma Release Assay for the Diagnosis of Tuberculosis

BACKGROUND: For the diagnosis of tuberculosis (TB), a variety of tests based on the patients' immune response has been introduced. We evaluated the clinical usefulness of combined anti-tuberculosis antibody (anti-TB Ab) test and Interferon-gamma release assay (IGRA), evaluating humoral and cellular immune response to Mycobacterium tuberculosis, respectively. METHODS: Among patients tested for IGRA, 78 patients diagnosed as TB and treated with anti-TB drug and 80 non-TB patients were included in this study. We used QuantiFERON-TB GOLD (QFT, Cellestis limited, Australia) for IGRA and an immunochromatographic assay, Easy Test TB (ASAN PHARM, Korea), for anti-TB Ab test. RESULTS: The sensitivity, specificity, and positive and negative predictive values of Easy Test TB were 23.1%, 98.8%, 94.7% and 56.8%, respectively. QFT had a significantly higher sensitivity than Easy Test TB (67.9% vs. 23.1%; P<0.05). The agreement between the two assays was poor (69.6%, k=0.190). Of the 18 cases with positive Easy Test TB, six (33%) showed negative QFT results. The combination of Easy Test TB and QFT had a significantly higher sensitivity than single QFT (75.6%, vs. 67.9%; P=0.031). CONCLUSIONS: The combination of Easy Test TB and QFT could be used to aid in a rapid diagnosis and early treatment of TB.

A Case of Pseudomembranous Tracheobronchitis Complicated by Coinfection of 2009 Pandemic Influenza A/H1N1 and Staphylococcus aureus / 감염과화학요법

An influenza pandemic due to a novel influenza A/H1N1 virus occurred after April 2009. This virus has some characteristics that differentiate it from the seasonal influenza virus. The 2009 pandemic influenza A/H1N1 virus can frequently infect the lower respiratory tract, and it might cause acute tracheobronchitis as well as pneumonia. Viral-bacterial interaction is well known as an important mechanism of the pathogenesis of respiratory complications of influenza. Herein, we report on a case that presented with pseudomembranous tracheobronchitis complicated by coinfection with 2009 pandemic influenza A/H1N1 and Staphylococcus aureus. We also review the relevent literature.

Onychomycosis with Dermatophytoma Completely Cured after Treatment of Regular Subungual Application of Antifungal Solution with Systemic Antifungal Therapy and Topical Nail Laquer Application / 대한의진균학회지

Systemic antifungal therapy is essential to cure onychomycosis but when used alone, its complete cure rate is less than 50%. Therefore, combination therapy is preferred to achieve higher cure rate of onychomycosis, especially severely infected onychomycosis. For effective treatment of onychomycosis, it is important how antifungal agents reach causative fungi in the nail lesion. If there are dermatophytoma or onycholysis, biofilms and space may disturb antifungal agent to reach the fungi in the nail lesion. If direct antifungal solution is applied to the space, it can be spread with capillary action to the space and fungi. A 57-year old male patient presented onychomycosis with infected nail matrix and dermatophytoma, which had recurred after combination therapy of oral and topical antifungal agents before. He had been treated with subungual antifungal solution added to systemic terbinafine (250 mg/day) and amorolfine nail lacquer for initial 3 months, and with subungual antifungal solution and nail lacquer for the next 4 months, and nail lacquer only for the rest period. After 3 months treatment, totally involved left great toe nail showed 50% of normal healthy nail growing from the proximal nail fold. His infected nails eventually showed complete normal nails 1 year after the initial treatment.

Comparison of Collagen-coated Polyethylene Terephthalate Disc Plate and Shell Vial Culture Method for the Isolation of Chlamydophila pneumoniae / 대한임상미생물학회지

BACKGROUND: Chlamydophila pneumoniae is one of the major respiratory infectious pathogens and can be accurately diagnosed by cell culturing. The author performed this study to compare the usefulness of the collagen-coated polyethylene terephthalate (PET) disc culture method and that of the shell vial method. METHODS: Twenty-nine sputums and 17 blood specimens collected from 46 patients for C. pneumoniae culture were inoculated into HeLa-229 cell monolayers cultured in shell vials and polyester plates. After incubation, they were stained using the indirect immunofluorescent method with genus-specific FITC-conjugated anti-chlamydia antibody. When both results were inconsistent, microimmunofluorescence results were used. RESULTS: HeLa-229 cells successfully formed monolayers in shell vials and collagen-coated PET plates in all cases. Positive inclusion bodies in HeLa-229 cells of shell vials and PET plates for C. pneumoniae culture were similarly stained with the indirect immunofluorescent method. Both methods showed consistent results with 20 positive and 22 negative cases. The total agreement between the PET plate and shell vial was excellent (91.3%, k=0.826). CONCLUSION: The collagen-coated PET disc culture method showed highly consistent results with that of the shell vial method, and no technical differences were experienced between the two methods. Therefore, the author concluded that the shell vial method could be replaced by the PET plate method for detection of C. pneumoniae.

Acute Mercury Vapor Inhalation Toxicity after Burning Charms: A Case Report / 대한구급학회지

Cinnabar is the mineral with mercury in combination with sulfur, and it has been used to make charms in China and Korea. If cinnabar is overheated, mercury vapor that is extremely hazardous or sometimes fatal can be released. We experienced 5 patients of a family who were exposed to mercury vapor when they burnt charms. One of them developed severe acute respiratory failure and the patient needed mechanical ventilation and extracorporeal membrane oxygenation (ECMO). Despite treatment with cortiocosteroid, D-penicillamine, ECMO and plasmapheresis, the radiologic findings of a patient worsened and he died.

The Clinical Significance of Bronchial Anthracofibrosis Associated with Coal Workers' Pneumoconiosis / 결핵및호흡기질환

BACKGROUND: In previous study, most patients with bronchial anthracofibrosis (BAF) were non-miners, and non-occupational old aged females. However, the clinical significance of BAF in patients with coal workers' pneumoconiosis (CWP) is unknown. METHODS: Among patients with CWP who transferred to our hospital for an evaluation of associated pulmonary diseases, 32 patients who had undergone a bronchofibroscopy (BFS) and chest computed tomography (CT) examination were evaluated for the association of the BAF using a retrospective chart review. RESULTS: Nine of the 32 CWP patients (28%) were complicated with BAF. Four of the 16 simple CWP patients (25%) were complicated with BAF. According to the International Labor Organization (ILO) classification by profusion, 2 out of 3 patients in category 1, 1 out of 8 patients in category 2 and 1 out of 3 patients in category 3 were complicated with BAF. Five out of 16 complicated CWP patients were complicated with BAF. Three out of 7 patients in type A and 2 out of 5 patients in type C were complicated with BAF. CWP patients with BAF had significantly greater multiple bronchial thickening and multiple mediastinal or hilar lymph node enlargement than the CWP patients without BAF. There was no difference in the other clinical features between the CWP patients with BAF and those without BAF. CONCLUSION: Many CWP patients were complicated with BAF. The occurrence of BAF was not associated with the severity of CWP progression. Therefore, a careful evaluation of the airway with a bronchoscopy examination and chest CT is warranted for BAF complicated CWP patients who present with respiratory symptoms and signs, even ILO class category 1 simple CWP patients.

A Case of Giant Pyogenic Granuloma on the Palm / 영남의대학술지

Pyogenic granuloma is one of the common benign vascular tumors of infants and children and it can also occur in adults. There are 25 reports of patients with pyogenic granuloma in the Korean medical literature. In three reports, giant pyogenic granuloma developed over 2 cm in size (1.3 x 0.7 cm, 1.2 x 0.8 cm and 1.1 x 0.7 cm, respectively). There have been no reports in the Korean medical literature of pyogenic granuloma over 2 cm in size. Herein, we report on a giant pyogenic granuloma on the palm of a 72-year old female. The lesion was of an unusually large size of 2.8 x 2.5 x 1.3 cm and we excised it by performing electrosurgery.

Clinical Characteristics of New Leprosy Patients for 15 Years (1992~2006) in Daegu / 대한피부과학회지

BACKGROUND: The prevalence and number of new cases of leprosy have recently markedly decreased in Korea. Therefore, the concerns about leprosy have also gradually decreased. For this reason, making the diagnosis of leprosy is not as easy as it was in the past, and it is more difficult to find new cases of leprosy. OBJECTIVE: The purpose of this study is to evaluate the epidemiologic and clinical features of recently diagnosed cases of leprosy in Daegu city, Korea. METHODS: Fifteen patients were diagnosed with leprosy according to the clinical features, histopathologic findings and bacteriologic examinations at Yeungnam University Hospital from 1992 to 2006. The epidemiological and clinical features according to age, gender, the place of residence, the duration of disease, the location of lesions, the cutaneous findings and the type of disease were evaluated retrospectively using the patients' medical records. The patients enrolled in this study were divided by the Madrid classification: the lepromatous type, the tuberculoid type and the intermediate or borderline group. RESULTS: Fifteen patients were diagnosed with leprosy during the past 15 years. The ratio of males to females was 1.5:1. Most of the patients (66.6%) were aged in their 40's and 60's. This shows that the rate of patients 40 years or older is on the increase. The male patients were younger than the female patients. The male patients were in their 20's and 40's, whereas the female patients' ages ranged from their 50's to 80's. The skin lesions showed various features and six (40%) of the 15 patients had sensory change. Eleven (73.3%) of the 15 patients were in the borderline group, followed by 3 patients with the tuberculoid type (20%) and 1 patient with the lepromatous type (6.7%). CONCLUSION: New leprosy patients have been persistently found and the findings of this study suggest that dermatologists play an important role in diagnosing and treating leprosy and they have to pay attention to diagnose new cases of leprosy.

The Influence of Adverse Drug Reactions on First-line Anti-tuberculosis Chemotherapy in the Elderly Patients / 결핵및호흡기질환

BACKGROUND: Pulmonary tuberculosis (TB) is still common disease among the elderly patients in Korea where the overall incidence of TB is decreasing. Adverse drug reactions (ADR) associated with anti-TB drugs occurs frequently. Especially the aged tends to have more frequent ADRs than younger ones. These ADRs can cause significant morbidity, compromise therapeutic effects of drugs and even induce drug resistance. Therefore we evaluated the effect of ADRs on the first-line anti-TB drugs in elderly patients with active pulmonary TB. METHODS: We retrospectively reviewed the charts and radiological findings of the patients with 65 and older who were bacteriologically confirmed as active TB and treated with standard anti-TB drugs for at least 6 months. Major ADR was defined with temporary or continuous stop of any first-line drugs intake. RESULTS: An ADR was noted in 54% of all patients. The incidence of major ADR was 32% in all elderly patients. Dermatologic ADR (9%) was the most common among the major ADRs. GI trouble (8%), arthralgia (6%), visual change (6%), hepatotoxicity (4%), and fever (1%) were also noted. The drugs responsible for major ADR were ethambutol (62%), pyrazinamide (35%), rifampin (18%) and isoniazid (9%). Major ADRs were associated with higher ESR level at the initiation of anti-TB drugs. CONCLUSION: First-line anti-TB drugs in elderly patients frequently caused the major ADRs. Therefore the elderly patients receiving anti-TB drugs should be closely monitored and better tolerable therapy should be considered as part of a TB research agenda.

A Case of Palmoplantar Lichen Planus Mimicking Secondary Syphilis

Lichen planus is a chronic inflammatory disease that affects skin, mucous membranes, hairs, and nails. According to the site of involvement, lichen planus can be subdivided into palmoplantar, mucosal, nail, or scalp types. Palmoplantar lichen planus is a rare subtype of lichen planus which may create difficulty in diagnosis, as the lesion is limited to the palms and soles. We report a case of a 37-year-old male with lichen planus who presented with multiple erythematous, scaly, hyperkeratotic papules on his palms and soles mimicking secondary syphilis.

A Case of Scabies in an Infant: Presumably Infested from His Nursery Nurse / 대한피부과학회지

Scabies is a skin disease involving infestation by Sarcoptes scabiei. The incidence of scabies in Korea has decreased during the past 20 years. Atypical cases can be misdiagnosed and can be a source of spreading in a family. A 2 month old infant had multiple erythematous papules, vesicles and yellowish crusted lesions on the trunk, extremities, face, palms and soles. It did not clear with treatments administered by local clinics. Clinical differential diagnoses included incontinentia pigmentii, erythema neonatorum, allergic contact dermatitis, and insect bite. Skin biopsy and mineral oil examination revealed scabies mites and eggs. A history from the family suggested that a nursery nurse taking care of the infant after his birth might be an infection source. His parents, his elder sister, his maternal grandmother and 2 other relatives were also infected from him.

A case of rifampicin-induced interstitial pneumonitis / 대한내과학회지

Rifampicin is a powerful agent for the treatment of pulmonary tuberculosis. However, it may induce several adverse effects, including rare cases of lung toxicity. Here, we report a case of rifampicin-induced interstitial pneumonitis. A 57-year-old woman diagnosed with cerebellar tuberculoma developed progressive dyspnea after the 5th day of anti-tuberculosis medication. Chest X-ray revealed newly developed ground glass opacities on both lower lung fields. Drug-induced pneumonitis was suspected and all anti-tuberculosis medications were halted. Transbronchial lung biopsy was consistent with desquamative interstitial pneumonitis. After clinical improvement, a rechallenge test with each anti-tuberculosis medication was attempted. No primary anti-tuberculosis drug except rifampicin triggered recurrence of symptoms, supporting a diagnosis of rifampicin-induced interstitial pneumonitis. Clinicians should be aware of this rare, but serious, side effect of rifampicin treatment.

A case of lemierre syndrome poorly responsive to medical treatment / 대한내과학회지

Lemierre syndrome is a rare clinical condition that is characterized by anaerobic oropharyngeal infections leading to septic thrombophlebitis of the internal jugular vein and frequent secondary metastatic infections. The accurate diagnosis and treatment, for early stage disease, is important because it may be associated with a high mortality rate if untreated. We present the case of a 34-year-old man who presented with a history of typical for the diagnosis of Lemierre syndrome. Supportive care with antibiotics did not improve the clinical condition. The clinical course improved after treatment with IV anticoagulant and surgical thrombectomy. In addition, he had the antiphospholipid syndrome, which is known to be a common cause of acquired arterial or venous thrombosis. Therefore, in this patient the associated antiphospholipid syndrome might precipitate an internal jugular venous thrombophlebitis after an oropharyngeal infection or might account for the poor response to medical treatment.

A Case of Pheochromocytoma that Initially Presented as Diffuse Alveolar Hemorrhage / 결핵및호흡기질환

A pheochromocytoma is a neuroectodermal tumor that originates from the chromaffin cells of the sympathetic system. Typical symptoms or signs are periodic attacks of paroxysmal hypertension, spell, palpitation, headache and sweating. However, the clinical presentation is quite variable. Therefore, an atypical clinical presentation sometimes makes a diagnosis difficult. Hemoptysis as a presenting symptom is very rare in pheochromocytoma. We recently experienced a patient with diffuse alveolar hemorrhage due to pheochromocytoma. A chest PA showed diffuse consolidation and ground glass opacities in both lungs. A chest CT showed diffuse consolidation and ground glass opacities in the central, middle and lower portion predominance of the lungs, sparing the costophrenic angles and apices of the lungs. In Korea, a case of pheochromocytoma that presented initially as massive hemoptysis due to diffuse alveolar hemorrhage has not been previously reported. We report the case with a review of the literature.