ABSTRACT
This study objective was to evaluate the cytokines associated with early events of hepatic fibrosis in schistosomiasis mansoni. Hepatic fibrosis was classified by ultrasonography in 94 patients. Immunological evaluation was performed by measurement of secreted cytokines (interleukin IL-5, IL-10, IL-13, interferon-gamma, tumor necrosis factor-alpha and transforming growth factors-beta) in peripherl blood mononuclear cells stimulated by Schistosoma mansoni antigens. Significantly, higher levels of IL-5, IL-10 and IL-13 were found in supernatants of SEA-stimulated PBMC from subjects with degree III hepatic fibrosis as compared to patients with degree I or II fibrosis, Significant increases in IL-5 and IL-13 levels were also observed in some of the subjects who remained untreated for one year following initial assessment and developed more serious fibrosis during this period. The data suggests a role for type 2 cytokines in early stages of hepatic fibrosis in human schistosomiasis mansoni.
Subject(s)
Humans , Animals , Male , Female , Child, Preschool , Child , Adolescent , Adult , Middle Aged , Cytokines , Leukocytes, Mononuclear , Liver Cirrhosis , Schistosoma mansoni , Schistosomiasis mansoni , Chronic Disease , Disease Progression , Severity of Illness IndexABSTRACT
É descrito um caso de sialolitíase da glândula submandibular direita, identificado através de radiografia panorâmica de rotina. O paciente - melanoderma, sexo masculino, 55 anos - relatou ter sido a condiçäo identificada há 12 anos, quando apresentou queixa de dor e aumento de volume durante as refeiçöes. Ao exame clínico-anamnésio, o paciente apresentou-se assintomático e referiu ter expelido duas "pedras" espontaneamente. A palpaçäo, pôde-se perceber a presença dos sialolitos que, na radiografia oclusal, se apresentaram em número de cinco. A ultrassonografia evidenciou uma imagem sugestiva de sialoadenite crônica e a ressecçäo completa da glândula foi procedida