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1.
Int. arch. otorhinolaryngol. (Impr.) ; 19(4): 349-353, Oct.-Dec. 2015. ilus
Article in English | LILACS | ID: lil-768334

ABSTRACT

Introduction Laryngeal neurofibromas are extremely rare, accounting for only 0.03 to 0.1% of benign tumors of the larynx. Objectives To report the first case of massive neck plexiform neurofibroma with intralaryngeal (supraglottic) extension in a 5-year-old boy with neurofibromatosis type 1 and to describe its treatment. Resumed Report This massive plexiform neurofibroma was surgically removed, relieving its significant respiratory obstructive symptoms without recurrence to date. Conclusion Massive neck plexiform neurofibroma with supraglottic part was found in a child with neurofibromatosis type 1; it should be included in differential diagnosis of stridor and neck mass in children. It was diagnosed and removed in early in childhood without recurrence.(AU)


Subject(s)
Humans , Child, Preschool , Diagnosis, Differential , Neurofibroma, Plexiform/diagnosis , Neurofibromatosis 1/genetics , Diagnostic Imaging , Laryngoscopy , Magnetic Resonance Imaging
2.
Int. arch. otorhinolaryngol. (Impr.) ; 19(2): 130-134, Apr-Jun/2015. tab, graf
Article in English | LILACS | ID: lil-747149

ABSTRACT

Introduction Surfactant protein A (SP-A) exhibits antimicrobial properties and interacts with a variety of respiratory tract pathogens. Objective The objective of this study was to detect the presence of SP-A and measure its alterations in chronic rhinosinusitis (CRS) and primary atrophic rhinitis (PAR) versus healthy controls. Methods Inferior turbinate and sinus mucosal biopsies were taken from 30 patients with CRS, 30 patients with PAR, and 20 healthy controls. Immunohistochemical staining for SP-A and polymerase chain reaction (PCR) amplification of SP-A messenger RNA were performed on nasal tissue samples. Results Immunostaining localized SP-A to the mucosa and submucosal glands in CRS specimens but failed to localize it in PAR specimens. Quantitative PCR showed a high, statistically significant increase in the SP-A levels of patients with CRS when compared with controls (p < 0.0001) and also demonstrated a significant reduction of SP-A in patients with PAR compared with controls (p < 0.005). Conclusion SP-A is significantly increased in CRS and decreased significantly in PAR and appears to be expressed by respiratory epithelial cells and submucosal glandular elements of the sinonasal mucosa. The potential therapeutic applications of surfactant in the enhancement of mucociliary clearance need to be studied. .


Subject(s)
Humans , Chest Pain/etiology , Chest Pain/therapy , Analgesics/therapeutic use , Antidepressive Agents/therapeutic use , Botulinum Toxins/therapeutic use , Esophageal Motility Disorders/complications , Esophageal Motility Disorders/therapy , Esophagus/surgery , Gastroesophageal Reflux/complications , Gastroesophageal Reflux/therapy
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