Platelet screening tests in patients with hepatic cirrhosis

This is the largest report to investigate the importance of platelet screening tests in patients with hepatic cirrhosis. One hundred eighty seven patients were examined in this study. On an appropriate clinical historic back ground, biochemical results and biopsy - proven cirrhotic patients were investigated. An abnormal bleeding time was found in 78 patients. There were significant differences between the group of patients with an abnormal bleeding time and the group with a normal bleeding time with respect to platelet count, prothrombin time and serum bilirubin concentrations [all p < 0.05]. We recommend to measure the bleeding time in patients with raised bilirubin concentrations or poor hepatic function, even if platelet counts and prothrombin time are with in [safe limits], before making a decision about potentially dangerous therapeutic measures, such as surgery

Glucose tolerance and insulin response in myocardial infarction patients in type 2 diabetes mellitus

To investigate glucose tolerance and insulin response in myocardial infarction patients in type-2 diabetic population, normoglycemic FDRs or type-2 DM patients and MI with out DM and having no history of type-2 DM in family. Sixty five MI patients and twenty two healthy controls were selected for study. Subjects were divided in to four groups. The study was conducted for the period of 9 months in cardiology ward of various hospitals. Fasting plasma glucose levels in diabetic patients were abnormally higher as compared to other groups. Mean insulin level of FDRs and diabetic MI patients were significantly higher than controls and non diabetics. When viewed with higher fasting glucose level in groups, indicates considerable resistance. Higher insulin levels of FDRs may indicate start of insulin resistance at normoglycemic control. Finally we conclude that insulin resistance appears to be risk factors in diabetics and FDRs MI groups, while in non diabetics, non FDRs, MI patients these risk factors does not seem to play major role

Calcium; serum and urinary in stone formers and non-stone formers

To evaluate the effects of serum calcium and urinary calcium excretion on upper urinary tract stone diseases in the Peshawar [a high stone incidence belt]. One hundred patients [age 20-60 years] who were suffering severely from upper urinary tract stone disease were selected from LRH and Hayatabad Medical Complex Hospitals of Peshawar, same numbers of healthy controls from the same region were also selected for the study. When results were summed up and test Parameters were compared, it was seen that mean serum calcium in stone formers was greater than that of non-stone formers [P<0.001]. Same pattern was also observed [P< 0.001] in both groups regarding mean urinary calcium excretion. We concluded that calcium is a definitive risk factor in upper urinary tract stone disease. However we suggest further work and research on wide scale population in order to evaluate this relation