effect of 5-fluoro-uracil in heat stress situations on thermoregulation, serum cortisol and serum electrolytes

Fourty two male albino rats were divided into seven equal groups. The first group served as control, the second and third group were subjected to thermal insult for 15 minutes and 30 minutes respectively. The fourth and fifth group received 5 fluorouracil intraperitoneally. The sixth and seventh group were subjected to the combined effect of 5-F.U. and thermal insult. Rectal temperature was measured before and after experiment in all animal groups. The animals were sacrificed by decapitation and blood was collected and serum cortisol and serum electrolytes were estimated. Data were statistically analysed and the results were discussed