ABSTRACT
Vitamin E administration prevented DEHP induced deleterious effects like (i) degenerative changes in the brain and thyroid, (ii) decrease in the activity of neuronal membrane Na+ - K+ ATPase, (iii) decrease in the concentration of insulin, cortisol and TSH, and (iv) the increase in T3 and T4 in female Albino rats. The results suggest use of vitamin E to prevent harmful effects of repeated transfusion of DEHP containing blood as in thalassemia patient. The possibility of using vitamin E to prevent the harmful effects of repeated transfusion of DEHP containing blood, as in thalassemia patients, is discussed.
Subject(s)
Animals , Blood Glucose/metabolism , Blood Preservation/methods , Blood Transfusion/methods , Diethylhexyl Phthalate/pharmacology , Female , Hydrocortisone/metabolism , Insulin/metabolism , Plasticizers/chemistry , Polyvinyl Chloride/chemistry , Rats , Rats, Wistar , Sodium-Potassium-Exchanging ATPase/metabolism , Thyrotropin/metabolism , Vitamin E/therapeutic useSubject(s)
Adult , Biopsy/instrumentation , Duodenoscopes , Duodenum , Female , Foreign Bodies/therapy , Humans , Needles , Pyloric Antrum , Surgical InstrumentsABSTRACT
A double blind, randomised, placebo controlled clinical trial was carried out in endoscopically proved chronic duodenal ulcer patients to compare the efficacy of sucralfate and ranitidine. Sucralfate 1 g four times daily and ranitidine 150 mg twice daily were found to be equally effective in inducing ulcer healing (73.1% and 82.1% respectively) during the 6-week treatment period. The rate of recurrence of the ulcer within six months after the initial treatment (84.2% and 82.6%) was also comparable in the sucralfate and ranitidine groups. Sucralfate and ranitidine are equally effective in ulcer healing and prevention of ulcer relapse.