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Indian J Pathol Microbiol ; 2011 Jul-Sept 54(3): 609-611
Article in English | IMSEAR | ID: sea-142058

ABSTRACT

Apparent hemoglobinopathy acquired after blood transfusion is an uncommon cause of diagnostic dilemma resulting in repeated testing and delay in the diagnosis. Out of the 1530 hemoglobin (Hb)- high-performance liquid chromatography (HPLC) performed at our hospital (May 2009 to April 2010), 3 pediatric cases of thalassemia major were detected having posttransfusion hemoglobinopathy with HbS ranging from 9.9% to 18.5%. In all three cases, there was no variant hemoglobin in earlier documented Hb-HPLC. It is important to be aware of and consider apparent transfusion-induced hemoglobinopathy in patients with unusual percentage of variant hemoglobin to avoid unnecessary treatment and counseling.


Subject(s)
Blood Transfusion/adverse effects , Child, Preschool , Chromatography, High Pressure Liquid , Hemoglobinopathies/diagnosis , Hemoglobinopathies/pathology , Hemoglobins/chemistry , Humans , Infant , Male , beta-Thalassemia/complications , beta-Thalassemia/therapy
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