ABSTRACT
【Objective】To investigate the role of mycophenolate mofetil (MMF) in the prevention of acute rejection in renal transplantation.【Methods】A total of 106 patients were randomized into two groups.One group received MMF (n=56),the other received azathioprine (Aza) (n=50).The time of the following study was within the first 6 months after transplantation.【Results】The rate of acute rejection of group receiving MMF was 20%,it′s lower than that of the group receiving Aza 44% (P<0.01).The recovery rate of acute rejection treated by methylprednisolone (MP),in MMF group 82% was higher than Aza group 55%.(P<0.05).Meanwhile the hepatotoxicity as well as cytomegalovirus (CMV) infection were lower in MMF group than those in Aza group.【Conclusion】MMF as a new anti-rejection drug could more effectively prevent acute rejection than Aza after renal transplantation,and has lower toxicity and side effect.
ABSTRACT
Autonomic functions were evaluated in 64 long-lerm maintenance hemodialysis patients,11 cases before and after transplantation and 15 controls.The results showed that adequate dialysis could stop the development of autonomic dysfunction (AD) in uremic patients,but the effect in improving AD was limited and not related to the duration of hemodialysis.Renal transplantation could reverse AD and result in complete normalization of autonomic function.