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Arana-Luna, Luara L.; Alvarado-Ibarra, Martha; Silva-Michel, Luis G.; Morales-Maravilla, Adrián; González-Rubio, María del C.; Chávez-Aguilar, Lénica A.; Tena-Iturralde, María Fernanda; Mojica-Balceras, Liliana; Zapata-Canto, Nidia; Galindo-Delgado, Patricia; Miranda-Madrazo, María Raquel; Morales-Hernández, Alba E.; Silva-Vera, Karina; Grimaldo-Gómez, Flavio A.; Hernández-Caballero, Álvaro; Bates-Martin, Ramón A.; Álvarez-Vera, José L.; Tepepa-Flores, Fredy; Teomitzi-Sánchez, Óscar; Fermín-Caminero, Denisse J.; Peña-Celaya, José A. de la; Salazar-Ramírez, Óscar; Flores-Villegas, Luz V.; Guerra-Alarcón, Lidia V.; Leyto-Cruz, Faustino; Inclán-Alarcón, Sergio I.; Milán-Salvatierra, Andrea I.; Ventura-Enríquez, Yanet; Pérez-Lozano, Uendy; Báez-Islas, Pamela E.; Tapia-Enríquez, Ana L.; Palma-Moreno, Orlando G.; Aguilar-Luévano, Jocelyn; Espinosa-Partida, Arturo; Pérez-Jacobo, Luis F.; Rojas-Castillejos, Flavio; Ruiz-Contreras, Josué I.; Loera-Fragoso, Sergio J.; Medina-Coral, Jesús E.; Acosta-Maldonado, Brenda L.; Soriano-Mercedes, Emely J.; Saucedo-Montes, Erick E.; Valero-Saldana, Luis M.; González-Prieto, Susana G.; Nava-Villegas, Lorena; Hernández-Colin, Ana K.; Hernández-Alcántara, Areli E.; Zárate-Rodríguez, Pedro A.; Ignacio-Ibarra, Gregorio; Meillón-García, Luis A.; Espinosa-Bautista, Karla A.; Ledesma de la Cruz, Cindy; Barbosa-Loría, Diego M.; García-Castillo, Carolina; Balderas-Delgado, Carolina; Cabrera-García, Álvaro; Pérez-Zúñiga, Juan M.; Hernández-Ruiz, Eleazar; Villela-Peña, Atenas; Gómez Cortés, Sue Cynthia; Romero-Rodelo, Hilda; Garzón-Velásquez, Katheryn B.; Serrano-Hernández, Cristina; Martínez-Ríos, Annel; Pedraza-Solís, María Luisa; Martínez-Coronel, Jorge A.; Narváez-Davalos, Iris M.; García-Camacho, Alinka S.; Merino-Pasaye, Laura E.; Aguilar-Andrade, Carolina; Aguirre-Domínguez, Juan A.; Guzmán-Mera, Pedro G.; Delgado-de la Rosa, Elizabeth; Flores López, Perla E.; González-Aguirre, Lilia L.; Ramírez-Alfaro, Edgar M.; Vera-Calderón, Heidi; Meza-Dávalos, María Lizeth; Murillo-Cruz, Juan; Pichardo-Cepín, Yayra M.; Ramírez-Romero, Eva F..
Gac. méd. Méx ; Gac. méd. Méx;158(spe): M1-M51, ene. 2022. tab, graf
Article in Spanish | LILACS-Express | LILACS | ID: biblio-1375542

ABSTRACT

resumen está disponible en el texto completo


Abstract Acute myeloid leukemia (AML) comprises a heterogeneous group of hematopoietic cell neoplasms of myeloid lineage that arise from the clonal expansion of their precursors in the bone marrow, interfering with cell differentiation, leading to a syndrome of bone marrow failure. AML is a consequence of genetic and epigenetic changes (point mutations, gene rearrangements, deletions, amplifications, and arrangements in epigenetic changes that influence gene expression) in hematopoietic precursor cells, which create a clone of abnormal cells that are capable of proliferating but cannot differentiate into mature hematopoietic cells or undergo programmed cell death. The diagnosis requires more than 20% myeloid blasts in the bone marrow and certain cytogenic abnormalities. Treatment will depend on age, comorbidities, and cytogenetic risk among the most frequent.

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