Lipid Peroxidation in Preeclampsia.

Hypertension in pregnancy is a leading cause of both maternal and fetal mortality and morbidity. Preeclampsia is characterised by hypertension and proteinuria. Lipid peroxidation is an important factor in the pathophysiology of Preeclampsia. The present study was undertaken to determine Serum Malondialdehyde (MDA) levels , a product of lipid peroxidation , in clinically diagnosed Preeclamptic women(n=30) and the values were compared with that of Normotensive pregnant women (n=30) aged between 18-30yrs. All of them were in their third trimester and were primigravida. Serum MDA was estimated by TBARS (thiobarbituric acid reactive substances) method. We observed that Serum MDA levels were significantly increased in Preeclamptic women (p <0.000) as compared to that of Normotensive pregnant women . Increased levels of lipid peroxiation product - MDA may contribute to the pathophysiology of Preeclampsia.

Prevalence of metabolic syndrome and insulin resistance in normal and abnormal glucose tolerant subjects in South India.

Background: Type 2 diabetes prevalence is increasing world wide, due to underline insulin resistance leading to metabolic syndrome. Subjects with abnormal glucose metabolism are at increased risk for Coronary artery disease. Thus the diagnosis of insulin resistance is useful to prevent the increasing complication of diabetes. Aims & Objectives: The present study was done in subjects with normal and abnormal glucose metabolism to find out the prevalence of metabolic syndrome and insulin resistance. Methodology: By oral glucose tolerance test (OGTT), 136 subjects were divided into normal glucose tolerance (NGT) , Impaired glucose tolerant (IGT) and diabetes mellitus (DM). Fasting glucose, total cholesterol, triglycerides, HDL – c, insulin, hsCRP were measured in all the groups. HOMA IR was calculated and based on IDF(International Diabetic Federation) Criteria each group is divided into with MS and with out MS. Results: All the parameters were compared between the groups. p value <0.05 considered as significant. Prevalence of metabolic syndrome in NGT was 26%, in IGT 43% and 86% among those with DM. The prevalence of insulin resistance was more in MS group compared to subjects without MS (NGT: 40% Vs 13.15%, DM 52% Vs50%). Conclusion: Metabolic Syndrome is one of the earliest detectable risk factors with increased insulin resistance.Thus diagnosing the subjects with metabolic syndrome can reduce the increasing prevalence of diabetes & helps in preventing the complication of type 2 diabetes.