ABSTRACT
Background: The quality of life in developing countries can be improved by enhancing the standards of medical treatment at all levels of the health care delivery system. Teaching hospitals have a special responsibility toward society to promote rational prescribing by their staff and, through them, the future generations of doctors. Methods: A sample of 1000 patient prescriptions was assessed retrospectively to assess the drug prescription patterns in the state of Goa. Results: Of 1842 drug products prescribed, the average number of drugs per prescription was 1.842. The total number of drugs prescribed by generic name was 1 (0.05%). An antibiotic was prescribed in 318 patient encounters (31.8%). Almost all drugs prescribed (n=1842, 99.67%) were on the essential drug list of India. During the study period, antibiotics were prescribed the most (n=318, 17.26%), followed by drug for cardiovascular system (n=265, 14.39%) and gastrointestinal tract (n=238, 12.92%). Conclusions: Baseline data gathered by this study can be used by researchers and policymakers. Further the problem-based basic training in pharmacotherapy; targeted continuing education can prove useful to medical profession to improve prescribing practice and public health administrators for promoting effective rational drug use.
ABSTRACT
Background: The objective of this study was to provide an extrinsic motivation for learning and allow it to translate into intrinsic motivation during the activity. To generate an interest and to have a better understanding of pharmacology by preparing models and posters. Methods: The present study was carried out among the second year MBBS students. The topic selected was “pharmacotherapy of diabetes mellitus.” A formal announcement was made 30 days in advance. Didactic lectures were taken as per schedule. Ninety-seven students were divided into 18 groups of 5-6 student’s each. Nine groups were allotted to prepare models and nine were allotted to prepare posters. On the assigned day student’s presented their posters and models with enthusiasm. The best three posters and three models were awarded. Feedback forms in the form of questionnaire were given to the students. The students had to grade the answers: 1: little help, 5: extremely helpful. 1-2: low score; 3: medium score; 4,5: high score. Results: Chi-square test was applied to all answers except eighth. The answers showed Chi-square value more than 9.21 and p<0.01, which is considered statistically significant. As for the eighth answer, 77.7% students scored it 4-5 (high score).The sample size for 1-2 (low score) was only 3: so Chi-square test was not applicable. Conclusions: The poster model competition did generate an interest in the topic. The students had a new avenue to express themselves and in the process gain more knowledge in an enjoyable manner. Learning is facilitated when students themselves play an important role in the learning process. Poster-model competition can be incorporated as a teaching-learning tool to encourage and motivate students who lack intrinsic motivation.
ABSTRACT
Knee osteoarthritis (OA) is a disease of the whole knee joint occurring due to an interaction between inflammatory, hypoxic, and mechanical pathways. Initial management includes monotherapy with analgesics or anti‑inflammatory agents, eventually switching over to combination therapy with steroids and/or newer drugs. Cardiovascular risks associated with non‑steroidal anti‑inflammatory drugs (NSAIDs) limit their long term use. Hence, novel target receptors or pathways, which remain unaffected by conventional therapy and modify disease are being increasingly looked for. Newer drugs such as glucosamine, chondroitin, methylsulfonylmethane, diacerein along with vitamins/minerals are commonly used as adjuncts to NSAIDs or as monotherapy. Because of their novel mechanisms of action and better safety profile they seem to be promising as disease modifying agents in the treatment of OA. Google, PubMed, Cochrane databases and Science Direct search was performed, and relevant articles were identified. This review focuses on the pathological targets which these drugs modify in order to bring about a symptom modifying effect.
ABSTRACT
Background: Fixed dose combinations (FDCs) refer to products containing two or more ingredients used for a particular indication in a single dosage form. Prescribing FDCs has become a routine affair in medical practice. There has been increase in the irrational FDCs in the recent past by leaps and bounds. The pharmaceutical companies are luring the physicians to prescribe their products even when they are not needed by the patients. The Indian laws too are not properly defined to grant marketing approvals of FDCs. Hence the rationality of a FDC has become one of the most controversial and debatable issues in general practice. Methods: We hence decided to analyze the existing FDCs in Indian market and study their rationality. Results: We observed that, although many brands of FDCs available are essentially rational as per WHO and Indian essential drugs lists, the irrational FDCs easily outnumber the rational ones. Hundreds of rational FDCs are also available which are not included in WHO or Indian essential drugs lists. A few FDCs with incorrect doses were also noted. Irrational FDCs not only cause more adverse drug reactions but the antibiotic FDCs are responsible for increasing the chances of resistance. A few of these are discussed for their irrationality. Conclusions: It is the need of the hour to raise our voice against the growing list of irrational FDCs and try to reduce the magnitude of this problem by sensitizing the undergraduates, the interns as well as the practitioners regarding their efficacy, safety, suitability, rationality and cost benefit.