ABSTRACT
The edentulous state represents a compromise in the integrity of the masticatory system . The common treatment option for rehabilitation of edentulous state is the conventional complete denture. Occlusal paths and Cuspal paths generated on the mechanical articulator often differ from those that are actually generated in the mouth . Functionally generated path technique is one such approach which aids in the automatic determination of the geometric harmonious relation between the functional occlusal path and condylar paths at chosen vertical dimension . This technique permits the registration of the cusp movements as determined by the functional mandibular movements and thus helps in development of harmonious occlusion. This article describes a case report in which a step by step approach was used to develop functionally generated occlusal path in fabricating a complete denture.
ABSTRACT
OBJECTIVE: To assess the responses to ATG and cyclosporin combination in patients of aplastic anemia. METHODS: Twenty three (17M: 6F) patients of aplastic anemia (11 very severe aplastic anemia (VSAA) and 12 severe aplastic anemia (SAA), were administered antithymocyte globulin and cyclosporin. RESULTS: The median age of patents was 8 years (range 6-12 years). Three patients died within 2 months of therapy. Twenty children (11 SAA and 9 VSAA) were finally analysed. Six months after the start of treatment, 8/20 (40%) patients responded-2 complete (CR) and 6 partial responses (PR). At the end of 1 year; 2 patients maintained CR and seven patients continued PR (overall responders 45%). The response was better in SAA (54.5%) with 2 CR and 4 PR; than in VSAA (33%) with 3 PR . Eleven (55%) children were alive without response. One patient developed AML 13 months later. CONCLUSION: We conclude that antithymocyte globulin and cyclosporin combination is an effective treatment for aplastic anemia patients who are ineligible for bone marrow transplantation.