ABSTRACT
In preparation for tracheal intubation during induction of anesthesia, the patient may be ventilated with 100% oxygen. To investigate the impact of acute isocapnic hyperoxia on endothelial activation and vascular remodeling, ten healthy young men (24±3 years) were exposed to 5-min normoxia (21% O2) and 10-min hyperoxia trials (100% O2). During hyperoxia, intercellular adhesion molecules (ICAM-1) (hyperoxia: 4.16±0.85 vs normoxia: 3.51±0.84 ng/mL, P=0.04) and tissue inhibitor matrix metalloproteinase 1 (TIMP-1) (hyperoxia: 8.40±3.84 vs normoxia: 5.73±2.15 pg/mL, P=0.04) increased, whereas matrix metalloproteinase (MMP-9) activity (hyperoxia: 0.53±0.11 vs normoxia: 0.68±0.18 A.U., P=0.03) decreased compared to the normoxia trial. We concluded that even short exposure to 100% oxygen may affect endothelial activation and vascular remodeling.
ABSTRACT
E descrito um caso de carcinoma epidermoide puro do estomago em mulher de 63 anos. O tumor estava localizado na regiao antro-pilorica e a histologia mostrou carcinoma epidermoide bem diferenciado, com muitas perolas corneas. A histologia desse tipo de tumor e brevemente discutida
Subject(s)
Carcinoma, Squamous Cell , Stomach NeoplasmsABSTRACT
Sao relatados tres casos de carcinoma verrucoso envolvendo o epitelio vulvar. Eles representam uma variante rara do carcinoma epidermoide, localmente invasiva e radiorresistente. A semelhanca dessa neoplasia com o condiloma torna dificil o diagnostico
Subject(s)
Middle Aged , Humans , Female , Vulvar Neoplasms , Carcinoma, Squamous CellABSTRACT
E feita a apresentacao de um caso de "tumor de celulas de Sertoli-Leydig" (OMS), denominacao calcada na tipagem histologica, preferivel a de "arrenoblastoma", ja que nem todos causam virilizacao e ha deles inclusive estrogeno-produtores. A literatura e revista sobre os aspectos histopatologicos e clinico-laboratoriais