ABSTRACT
There is a high demand for stroke rehabilitation in the Brazilian public health system, but most studies that have addressed rehabilitation for unilateral spatial neglect (USN) after stroke have been performed in high-income countries. Therefore, the aim of this study was to analyze USN patient recruitment in a multicenter noninvasive brain stimulation clinical trial performed in Brazil and to provide study design recommendations for future studies. We evaluated the reasons for exclusion of patients from a multicenter, randomized, double-blinded clinical trial of rehabilitation of USN patients after stroke. Clinical and demographic variables were compared between the included and excluded patients. A descriptive statistical analysis was performed. Only 173 of the 1953 potential neglect patients (8.8%) passed the initial screening. After screening evaluation, 87/173 patients (50.3%) were excluded for clinical reasons. Cognitive impairment led to the exclusion of 21/87 patients (24.1%). Low socioeconomic status led to the exclusion of 37/173 patients (21.4%). Difficulty obtaining transportation to access treatment was the most common reason for their exclusion (16/37 patients, 43.3%). The analyzed Brazilian institutions have potential for conducting studies of USN. The recruitment of stroke survivors with USN was restricted by the study design and limited financial support. A history of cognitive impairment, intracranial stenting or craniectomy, and lack of transportation were the most common barriers to participating in a multicenter noninvasive brain stimulation trial among patients with USN after stroke.
ABSTRACT
The cryosurgery is a very useful therapy for the treatment of a variety of neoplastic and non-neoplastic processes. Nevertheless, it is still poorly described as an option for the treatment of specific cutaneous neoplasms, such as squamous cell carcinoma. The purpose of the present study was to analyze the clinical response of cryosurgery for the treatment of squamous cell carcinoma in cats. For this 13 squamous cell carcinoma lesions were selected in 11 cats, diagnosed through citopathological and/or histopathological examinations. The lesions were frozen using liquid nitrogen spray, and the evaluations were performed in the moment of freeze and approximately every 15 days until the wound was completely healed. The response of cryosurgery was considered complete with tumoral remission on 38.5% of the cats, and partial on 46.1%. The main complications included crusting and nostril stenosis. The presented results suggested that cryosurgery is effective and may be a viable option for the treatment of squamous cell carcinoma in cats. The effectiveness of the therapy; however, depends on the correct selection of the candidates for cryosurgery based on the lesion size, and the attendance to some criteria, such as the freezing time and post-operative care.(AU)
A criocirurgia tem se mostrado uma terapia de grande auxílio no tratamento de uma variedade de processos neoplásicos e não neoplásicos. Apesar disso, ainda é pouco descrita a utilização da criocirurgia como opção de tratamento de neoplasias cutâneas específicas, como o carcinoma de células escamosas. Objetivou-se com o presente estudo analisar a resposta clínica da criocirurgia para o tratamento do carcinoma de células escamosas em gatos. Para isso, foram selecionadas 13 lesões do tipo carcinoma de células escamosas em 11 gatos, diagnosticadas por meio de análise citopatológica e/ou histopatológica. As lesões foram congeladas por meio de nitrogênio líquido na forma de spray, e as avaliações realizadas no momento do congelamento e aproximadamente a cada 15 dias, até a completa cicatrização da ferida. A resposta da criocirurgia foi considerada completa, com remissão tumoral em 38,5% dos gatos e parcial em 46,1% destes. As principais complicações verificadas incluíram a formação de crostas e estenose de narina. Os resultados apresentados no presente estudo sugerem que a criocirurgia é efetiva e pode ser uma opção viável para o tratamento do carcinoma de células escamosas em gatos. O sucesso do tratamento, entretanto, depende da correta seleção dos candidatos à técnica quanto ao tamanho da lesão, e do atendimento a alguns critérios, como o tempo de congelamento e os cuidados pós-operatórios.(AU)
Subject(s)
Animals , Cats , Carcinoma, Squamous Cell/surgery , Carcinoma, Squamous Cell/veterinary , Cryosurgery/veterinary , Skin Neoplasms/veterinaryABSTRACT
With the purpose of shedding light on some doubts in veterinary oncology, the present article intends to compare the results of histopathological and immunohistochemical examinations of unspecific round cell neoplasia, to realize immunophenotyping of canine lymphoma cases, to establish the T or B origin of neoplastic cells, and to determine the degree of proliferation and apoptosis of lymphomas by immunohistochemistry. Of 11 animals presenting immunohistochemical diagnosis of lymphoma, five had been diagnosed as Lymphoma by HE staining of histopathological slides and six had been classified as unspecific round cell neoplasia. All cases submitted to immunohistochemical examination were T-cell lymphomas. There was a positive correlation between cell proliferation and apoptosis. The comparison among histopathological and immunohistochemical results obtained in the cases examined in the present study suggested that immunohistochemistry is essential for the differentiation of round cell neoplasia.
Com o objetivo de sanar algumas dúvidas na área da oncologia veterinária, o presente artigo pretende comparar os resultados dos exames histopatológicos e imuno-histoquímicos de neoplasias de células redondas inespecíficas, realizar imunofenotipagem dos casos de linfoma canino e determinar o grau de proliferação e apoptose de linfomas. Dos 11 animais que apresentaram diagnóstico imuno-histoquímico de linfoma, cinco foram diagnosticados como linfoma por coloração HE das lâminas histopatológicas e seis foram classificados como neoplasia de células redondas inespecíficas. Todos os casos submetidos ao exame imuno-histoquímico foram de linfomas de células-T. Houve uma correlação positiva entre a proliferação celular e apoptose. A comparação entre os resultados histopatológicos e imuno-histoquímicos obtidos nos casos analisados sugeriu que a imuno-histoquímica é essencial para a diferenciação das neoplasias de células redondas.
Subject(s)
Animals , Dogs , Lymphoma/classification , Neoplastic Cells, Circulating/immunology , Neoplastic Cells, Circulating/pathologyABSTRACT
Os autores estudaram, retrospectivamente, 509 criancas admitidas na Unidade de Pneumologia do Instituto da Crianca "Prof. Pedro de Alcantara" do Hospital das Clinicas da FMUSP, no periodo de 1975 a 1980, portadoras de pneumopatias agudas, cronicas ou de repeticao. Destas, foram estudadas 15 criancas com idade variando de dois meses a dois anos, nas quais o raio X contrastado de esofago, estomago e duodeno revelou sinais de incoordenacao motora da cricofaringe (IMF) ou refluxo gastresofagico (RGE) associado a malformacoes do esofago. Havia historia clinica de quadros respiratorios de repeticao concomitantemente a vomitos e/ou regurgitacao e/ou engasgos frequentes. Dez casos eram portadores de IMF, quatro de RGE e um de fistula esofago-traqueal em H
Subject(s)
Infant , Child, Preschool , Humans , Male , Female , Deglutition Disorders , Gastroesophageal Reflux , Pneumonia, Aspiration , Tracheoesophageal FistulaABSTRACT
Os autores estudam os aspectos clinicos e radiologicos de comprometimento de seios da face em 93 pacientes com broncopneumopatias de repeticao. Verificam que a sinusopatia pode ocorrer inclusive em criancas de baixa idade e e mais frequente naquelas com manifestacoes alergicas. A evolucao com recidivas ou para a cronicidade e mais comum em pacientes com mucoviscidose, com hipertrofia de adenoides e nos portadores de rinopatias alergicas
Subject(s)
Infant , Child, Preschool , Child , Adolescent , Humans , Male , Female , Bronchial Diseases , Rhinitis, Allergic, Perennial , SinusitisSubject(s)
Adolescent , Adult , Middle Aged , Humans , Male , Female , Critical Care , Enteral NutritionABSTRACT
O autor apresenta os resultados do estudo de 11 criancas com suspeita clinica de imunodeficiencia, portadoras de pneumopatias cronicas. Foi possivel detectar sete casos de deficit na resposta celular, dois casos de deficiencia seletiva de IgA, um caso de hipogamaglobulinemia adquirida e um caso de doenca granulomatosa cronica. Quatro das criancas com deficit na resposta celular, receberam estimulacao com levamizole