[ breast focal discrete fibrocystic lesion with phyllodes tumor characteristic: a case Report]

Both fibrocystic change and phyllodes tumor are classified as fibroepithelial tumors of breast which are composed of epithelial and stromal components. Although as the most common benign breast lump fibrocystic lesions are known by symptom such as pain, nipple discharge, heaviness, usually in women's third decade of life, mammographic and sonographic features often render them almost indistinguishable from phyllodes tumor. In view of the essential differences in terms of therapeutic planning which exist between these two tumors, their early and precise distinction is crucial to avoid problem such as patients' anxiety and unwarranted tumors operation. In this article a case of fibrocystic change in a 24 year old woman is reviewed in which clinical signs and symptoms and mammographic changes are indication of phyllodes tumor

comparison of intramuscular and intravaginal suppositoar forms of progesterone for supporting the Luteum phase in ART cycles

Up to seventh week of gestation, progesterone secreted from the ovary is necessary to preserve the pregnancy. In the ART cycles GnRH-a is prescribed and oocytes and granulosa cells or retrieved, both causes corpus luteum insufficiency, so corpus luteum should be supported the best way is progesterone prescription. In this research we compare intramuscular and intravaginal suppositoar forms of progesterone for preserve the pregnancy. A prospective cross sectional evaluation on 193 patients was designed. All of them were on IVF or ICSI cycles. The patients were randomly divided into two groups. Intramuscular progesterone was prescribed in 138 and intravaginal progesterone [supp cyclogest] in 54 patients. The outcome of pregnancy was analyzed using statistical trials including t-test and chi-squre. The two groups were similar duo to age - the ethiology causes of infertility - the doses of proscribed HMG ampule - FSH titrago - the number and grade of transferred embryos. The day after HCG presciption until the end the seventh week in the first group [138 patients] intramuscular progestrone [50 mg/bid] and in the second group [54 Patients] supp of cyclogest [400 mg/bid] was presented. The rate of positive pregnancy test, abortion, successful poegnancy in this two groups were similar. Intramuscular or intravaginal progesterone for supporting corpus luteum in IVF or ICSI cycles have the same effect but the intramuscular route is cheaper

Evaluation of effect of topical phenytoin on wound healing [increasing wound tensile strength and collagen deposition] in rats

Background: Delyed healing and dehiscence of operative wounds represent a significant clinical problem. Sporadic reports indicate that phenytoin may significantly promote wound healing following topical application

Material and Methods: Ten male rats each received 4 dorsal skin incisions and were sutured immediately on proliferative and early maturation phase. The incisions were infiltrated with phenytoin or normal saline for controls randomly. The wounds were harvested 18 days after wounding and were assessed by tensiometric measurement and microscopic examination. Data was expressed as mean [sd] and were analysed using student's paired T test

Results: Application of phenytoin, in both proliferative and maturation phases, resulted in a significant increase in wound tensile strength [34.16[8.15] N and 32.18 [7.43] N in treated wound versus 28.58 N and 26.7[4.93] N controls respectively, n = 20; P<0.01]. Application of phenytoin in these two phases had no difference. The rise in wound tensile strength was associated with increase in wound collagen deposition

[Correlation of p53 protein expression and clinicopathologic features in ovarian epithelial tumors]

Ovarian tumors are one of the most common neoplastic diseases in women. p53 is a nuclear phosphoprotein, and its mutant form has an oncogenic role in many human cancers. In this study, p53 expression in benign, borderline and malignant ovarian tumors is assessed, and then its relationship with tumor histology, clinical factors and the stage of disease is evaluated. 50 cases of ovarian epithelial tumors including 24 malignant, 6 borderline, and 20 benign tumors, were collected. The expression of p53 was studied immunohistochemically using paraffin embedded ovarian epithelial neoplastic tissue. The correlation between p53 expressions in ovarian epithelial tumors and clinicopathologic variables were analyzed. None of the benign tumors were positive for p53, but 66%of the malignant tumors and 16.6% of borderline tumors were positive. There was no significant association between p53 protein expression and histopathologic type of malignant tumors [P=0.85], stage of disease [P=0.3] and the age of patients [P=0.39]. P53 can be detected in malignant ovarian epithelial tumors. There was no significant relationship between p53 expression and clinical or histopathologic variables. According to the results of the study, other expanded studies about p53 role in prognostic, and therapeutic approaches, are recommended

[Four cases of intraepithelial neoplasia of vulva: case report]

Background and Objective: VIN [Vulval Intraepithelial Neoplasia] is a rare disease that can be observed in young females. In this study, four VIN cases referred to the gynecologic oncology clinic of Ghaem and Omid hospitals [Mashhad] during a year are going to be introduced

Cases: Four patients [Mean age 30 years] suffering from mass and itching vulva referred to our center. All had multifocal lesions. Risk factors such as HIV, STD and smoking showed negative results. Despite not having the possibility of examining HPV infection, two patients had koilocytosis pattern in pathologic examination. No patients had CIN and other related genital cancers. Surgery treatment in the form of local excision during the usage of acetic acid was performed in the operating ward. In two patients, the removed marginal tissue showed positive malignancy results had gone through orthovoltage radiotherapy. The recurrence was observed in one patient after one year who was reoperated in the form of skinning vulvectomy

Conclusion: According to this fact that the major cause of VIN is STD and in more than 80% of patients is HPV infection the decrease in incidence of STD can especially lead to VIN decrease and vulva cancer naturally