Predictors of outcome after childhood ischemic stroke at a referral neuroscience hospital in Bangladesh

Background: Though stroke in the pediatric age group is not as common as in adults, it is now recognized as an important cause of morbidity and mortality in children. For proper management of childhood stroke, it is very important to know about the spectrum of clinical presentation, risk factors, and neuroimaging features that can affect the outcome following stroke. The aim of the study was to identify predictors of outcomes in children with ischemic stroke treated at a referral neuroscience hospital in Bangladesh. Methods: A one-year prospective cohort study was conducted at the department of pediatric neurology, national institute of neurosciences and hospital (NINS and H), Dhaka, from March 2021 to February 2022. It involved 42 consecutive pediatric ischemic stroke patients aged 1 month to 18 years. Post-operative outcomes were assessed clinically, biochemically, and with imaging at discharge, 1 month, and 6 months post-discharge using the PSOM scale. Statistical analysis was performed using SPSS version 23.0, with significance set at p<0.05. Results: In our pediatric ischemic stroke study (n=42), most patients (76.2%) were aged 1-5 years, with iron deficiency anemia (59.5%) as the predominant risk factor. Anterior circulation stroke was common (90.5%), and PSOM assessments showed 28.6% favorable outcomes at discharge, increasing to 76.2% at 6 months. Seizure, speech difficulty, altered consciousness, and CNS infection were linked to poorer outcomes (p<0.005). Conclusions: Childhood stroke poses significant morbidity, with variable neurological outcomes. Factors like seizure, speech difficulty, altered consciousness, and CNS infection predict poorer outcomes.

Clinico-pathologic profile and pattern of p53 expression of lung adenocarcinoma in non-smokers and smokers in a tertiary cancer centre

Background: Lung cancer is the most common cause of cancer mortality worldwide. Smoking is undoubtedly the major risk factor of lung cancer in both genders. Adenocarcinoma is the most common form of lung cancer in both men and women and the most prevalent subtype in non-smokers. Lung cancer in never-smokers is a distinct entity with sparse studies. We studied the clinico-pathologic profile of lung adenocarcinoma and pattern of p53 expression in smokers and non-smokers. Methods: A prospective study involving 100 lung adenocarcinoma cases from January 2020 to June 2021 examined p53 expression using immunohistochemistry. Trucut biopsies, fine needle aspiration cytology (FNAC) cell blocks, and pleural effusion were analyzed to identify the predominant morphological subtype of the lung adenocarcinoma. Results: The most common histological pattern of lung adenocarcinoma was solid, and the presenting symptoms were cough and dyspnoea in both smokers and non-smokers. The incidence of lung adenocarcinoma was higher in non-smokers in the study. p53 expression had a significant correlation with smoking but not with stage of disease or morphological subtype of lung adenocarcinoma. Conclusions: p53 mutation has a statistical correlation with smoking in adenocarcinomas in our population. Among the adenocarcinoma cases in our study, non-smokers predominate (n=53). Even though our study showed the p53 mutation has no statistical correlation with the stage of the disease or histological subtype in adenocarcinoma, more cases need to be studied to prove this observation.

Psychological patterns in pre-graduate students in Tirupati district

Background: Adolescent age can be a stressful experience for young people with a wide range of concerns. Comprehensive studies on psychological patterns among pre-graduate students in India are meagre. Therefore, this study aimed to assess psychological morbidities and quality of life in them. Methods: The study recruited 567 students aged 15-18 years, who pursued pre-graduate courses at government (300) and private (267) colleges in and around Tirupati and Chandragiri, Andhra Pradesh, India. Information was collected about their physical and psychological health, substance abuse and usage of electronic gadgets. The levels of stress, anxiety, depression, and sleeplessness were assessed. Results: A significant association was observed in the levels of stress, anxiety, and depression among government and private college students at levels of 1%, 10% and 5%, respectively. Higher levels of depression were observed in 44.8% of students; depression was high in girls and government college students. Often, girls experience higher levels of stress leading to psychological illnesses than boys due to their inability to share their feelings and fears among family members. The proportion of poor family health indicators was significantly high in students with moderately low levels of anxiety. Poor sleep had decreased as the depression worsened from borderline to higher levels in boys and decreased even with mild mood disturbances in girls. Conclusions: Management strategies at personal, institutional and social levels are to be developed after understanding the risk factors of psychological morbidities in students.

Integrated analysis of health dynamics in esports: injury profiles, intervention strategies, and health optimization protocols

The rapidly expanding realm of Electronic Sports (eSports) has captivated global attention, blurring the lines between virtual entertainment and traditional athletics. As participation in eSports continues to rise, these competitive gaming platforms are increasingly recognized as legitimate sports. However, with this surge in participation, there's a simultaneous increase in the susceptibility to health hazards, spanning both physical and psychological domains. Musculoskeletal injuries, caused by extended sedentary postures and repetitive motions, afflict eSports athletes, resulting in discomfort in the wrists and hands, alongside back and neck problems. The prolonged exposure to screens predisposes participants to vision-related concerns, highlighting the imperative of addressing ocular health within the eSports community. Simultaneously, the intense cognitive demands and competitive pressures exacerbate mental health challenges, resulting in depression and anxiety among players. Similar to traditional athletes, eSports competitors need appropriate protocols to minimize injury risks, alongside access to medical intervention to manage potential health hazards. This review comprehensively analyses the health dynamics of eSports, elucidating injury profiles, intervention strategies, and health optimization protocols essential for safeguarding the well-being of eSports athletes and enhancing awareness within the eSports community.

Implementing dietary counselling in family practice for diabetes control and prevention

The importance of dietary counselling in family practice for managing and preventing diabetes is the focal point of this review, highlighting its integral role in chronic disease management. With diabetes increasingly prevalent worldwide, there is a critical need for effective management strategies, with dietary interventions playing a key role. Family practitioners, often the initial point of contact for patients, have a unique opportunity to implement these dietary changes, which are pivotal in influencing diabetes outcomes and averting long-term complications. Despite facing challenges such as limited time and the need for specialized knowledge, dietary counselling in family practice stands as a proactive measure focused on prevention and early intervention. It adopts a patient-centered approach, where dietary habits and preferences are assessed, and personalized, evidence-based advice is provided. The inclusion of dietitians in primary care teams, utilization of technology for support, and advocacy for policy reforms are recommended to enhance the effectiveness of dietary counselling. Despite various obstacles, integrating dietary counselling into routine care remains a significant advantage, promoting healthier lifestyle choices and effectively managing the increasing burden of chronic diseases.

The impact of electronic prescribing systems on clinical pharmacy practice

This review explores the impact of electronic prescribing (e-prescribing) systems on clinical pharmacy practice, highlighting the potential benefits and challenges associated with their use. Medication errors, a significant concern within healthcare settings, have been shown to decrease with the adoption of e-prescribing, offering a promising tool to enhance patient safety and reduce adverse drug events. However, the transition from traditional handwritten prescriptions to electronic methods introduces new challenges, including the emergence of new types of errors, such as incorrect drug selection, and potential increases in mortality rates, as observed in pediatric patient. Furthermore, it discusses the limited exploration of e-prescribing in primary care and community pharmacy settings, areas that require further investigation to fully understand the benefits and burdens of e-prescribing use. By examining barriers related to person, tasks, environment, tools and technologies, and organizational factors, this review emphasizes the importance of considering various aspects that influence the efficacy and safety of e-prescribing systems. The findings suggest a critical need for incorporating human factors principles in the design and evaluation of these systems to ensure they effectively support clinical pharmacy practice and enhance patient care.

Knowledge, attitude and perceived barriers to telemedicine among medical professionals: a cross sectional study

Background: Telemedicine, an evolving technology in India's healthcare sector, offers promising avenues for improving healthcare accessibility and delivery. Its successful implementation relies on several factors, including the comprehension of its concepts, skill acquisition, attitude toward technology, and conducive work environments among healthcare professionals. Despite the pressing need for enhanced healthcare in developing countries like India, telemedicine remains more advanced in developed nations. The objective of this study was to evaluate the knowledge, attitude, and perceived barriers to telemedicine among medical professionals at government medical college Trivandrum and KIMS health Trivandrum. Methods: A cross-sectional survey involving 150 medical professionals across various departments was conducted using a structured questionnaire via the Kobo toolbox, an online survey tool. The collected data were analyzed to assess the understanding of telemedicine, attitudes toward its adoption, and barriers encountered by respondents. Results: The analysis revealed that while a commendable 35.3% of respondents exhibited a good understanding of telemedicine, the majority 64.7% lacked sufficient knowledge in this domain. However, there was a positive disposition towards telemedicine adoption, with 64.7% displaying strong positive attitudes, 24.7% expressing moderate attitudes, and 10.7% indicating lower inclinations. Notably, human resource availability emerged as the most prevalent barrier, while sustainable practices were cited least frequently. Conclusions: While many medical professionals showed support for telemedicine, their knowledge was limited, and the study identified multiple barriers to its adoption. Urgent action is needed to narrow the disparity between telemedicine's potential and its actual use in India's healthcare system.

Conservative management of traumatic brachial plexus injury: a case report

Brachial plexus injury (BPI) is one of the devastating conditions for patients, which has a negative impact on patients' quality of life. It renders patients with an inability to achieve functional independence. With advancements in surgeries and rehabilitation, improvement in these domains is possible. This case report describes the rehabilitation of a 28-year-old male patient. Being a driver by occupation and the only earning member in the family, upper limb function was essential for functional independence and resume work. After examination, problems were identified, goals were set, and intervention was planned. The patient took 2 months of inpatient rehabilitation six days a week. After completion of treatment, the patient was independent in basic and instrumental activities of daily living. The study concludes that structured, evidence-based physiotherapy treatment is effective in achieving functional independence and reducing disability in patients with traumatic BPI.

Study of p40 is superior to p63 for the diagnosis of pulmonary squamous cell carcinoma on cytological smears

Background: Histology and genetically driven management are the current standard in carcinoma lung. Adequate tissue is a challenge in a few cases. While liquid biopsy is an, it’s an always preferred to get an initial cyto/histo morphological confirmation. While the immune-histo chemistry (IHC) is a proven method to differentiate the squamous vs adeno carcinoma, the role of various “immuno-cyto-chemical” makers were not studied widely. Methods: This is a retrospective (July 2018 to December 2018) for random sample collection and prospective (Jan 2019-August 2019) study conducted from in the Department of pathology, govt. chest hospital Osmania medical college, Hyderabad as a part of PG dissertation, 120 subjects with cytological diagnosis of non-small cell lung carcinoma were analyzed during this period and others were excluded. Results: Out of 120 cases 80-adenocarcinoma (ADC) and 40-squamous cell carcinoma (SCC). Most of the patients are in 61-70 years, 20 are 71-80 years, 20 between 51-60 and 10 are between 40-50 years. In this study sensitivity of p63 and p40 is equal, but specificity and positive predictive value are higher for p40 for diagnosis of SCC. Conclusions: Immuno-cyto-chemistry is still a valid option in selected cases where getting a biopsy is difficult. Our findings recommend the use of p40 immuno staining rather than p63 as a squamous cell marker.

Evaluation of current physical symptoms and psychological sufferings of patients during attending department of palliative medicine in a tertiary care hospital

Background: Empirical evidence indicates that anxiety and depression in cancer patients are often overlooked, leading to insufficient assistance for their psychosocial needs. Distinguishing between clinical anxiety and depression and the typical emotional distress post-cancer diagnosis can be challenging but holds significant implications for coping strategies and outcomes. The aim of this study was to assess current physical symptoms and psychological sufferings of patients� during attending in a Palliative care department of a tertiary care hospital. Methods: This cross?sectional study was conducted among 191 patients with cancer attending the department of palliative medicine, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh from November 2021 and March 2022. Data was collected by face?to?face interview using a structured questionnaire. Depression and anxiety were evaluated using a modified version of the primary care evaluation of mental disorders guide. Results: 47 participants (20.7% prevalence of depressive disorders and 13.9% prevalence of anxiety disorders) met the diagnostic criteria for at least one anxiety or depressive disorder, according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. The 95% confidence interval for these results was between 20.2 and 29.0. Conclusions: In summary, depression and anxiety disorders are prevalent among patients in palliative care, significantly reducing the quality of life for those facing cancer-related mortality.

Exposure of children to fine particles (PM2.5 and PM10) in schools in the health districts of Yopougon, Abidjan

Background: In Africa, the school environment is becoming a growing concern, as concentrations of fine particles inside classrooms are very high. We decided to estimate the level of exposure to PM2.5 and PM10 of schoolchildren in the health districts of Yopougon in Abidjan. Methods: This was an analytical cross-sectional study of pupils aged 8 to 14 years in the health districts of Yopougon. Our study was conducted from 24 November 2020 to 18 January 2021. The pupils were selected by two-stage random sampling. A real-time fine-particle measurement instrument, the DYLOS 1700, and the ISAAC questionnaire were used to collect the parameters studied. Results: We surveyed 881 pupils from 08 schools. The sex ratio (M/F) of the pupils was 0.9 and the mean age was 12 years. Measurements of PM2.5 and PM10 levels in the classrooms were 30 times higher than WHO standards and ranged from 200 to 1000 µg/m3 and 1000 to 3000 µg/m3 respectively. There was a significant link between the presence of pollution sites near schools and the increase in PM2.5 and PM10 levels in classrooms. Clinical manifestations suggestive of asthma in pupils were significantly associated with high levels of PM2.5 and PM10. Conclusions: Pupils in Yopougon’s schools are exposed to high level of fine particle pollution that exceed WHO standards. Respecting and applying pollution reduction measures will help to create a school environment that is favourable to the respiratory health of pupils.

A Quasi-experimental study on the effectiveness of primary caregiver social support capacity on self-management practices of clients living with type II diabetes in Machakos county, Kenya

Background: Diabetes is a fast-growing public health emergency, projected to affect 643 million people by 2045. While primary caregiver social support can influence the self-management practices of Type 2 diabetes (T2D) clients, there's often limited capacity to provide it. The study determined the effectiveness of enhanced caregivers' social support capacity on self-management practices of T2D clients in Machakos. Methods: A six-month quasi-experimental study design that adopted quantitative and qualitative data collection and analysis approaches. Primary caregivers at the Matungulu intervention site were trained on T2D self-management and types of social support, with no intervention conducted at the Masinga control site. Results: Over 90% of the 227 primary caregivers were female, with a mean age of 43.28, supporting approximately three T2D clients each. Post-intervention, a 27.2% change in capacity to identify all T2D self-management practices was noted compared to a 7.6% change in the control group. The greatest contribution was in the primary caregivers' ability to provide tangible, followed by emotional and informational social support, resulting in a statistically significant improvement in the self-management practices in the intervention site, B=0.140 (95% CI: 0.072, 0.208), t=4.046, p<0.001. Consequently, the difference in blood glucose levels was statistically significant, crude OR=3.213 [95% CI: 2.039, 5.063], p<0.001. Conclusions: Enhanced capacity to provide social support positively correlates with the T2D clients' self-management practices. Further investigation of factors that hinder the full realization of primary caregiver social support capacity benefits in improving self-management capacities among T2D clients is recommended.

Characteristics of medical students with problematic smartphone use: a cross-sectional study

Background: Excessive smartphone use is common among university students and can negatively affect students’ mental health, but data from Middle-East countries is scarce. Objective of the study was to determine the characteristics of medical students affected by and the prevalence of problematic smartphone use in a sample of Iranian medical students. Methods: This cross-sectional study was conducted in a large Iranian medical university. A convenience sample of 356 students of different years of medical training were recruited. Data on socio-demographic characteristics, daily estimated average time using a smartphone, and main motivations to use a smartphone were collected through a self-reported questionnaire. Problematic smartphone use (PSU) was evaluated using the smartphone addiction scale – short version (SAS-SV) questionnaire. Backward logistic regression analysis was used to understand independent factors associated with PSU. Results: Overall, two-thirds of Iranian medical students were affected by PSU, including 68.5% of male and 64% of female students. Students who lived alone had significantly higher SAS-SV scores than those who lived with their families (p=0.007). Additionally, students with daily smartphone use >4 hours were 3.2 times more likely to be diagnosed with PSU (p<0.001). Social media use was the main motivation that strongly predicted the presence of PSU among medical students (adjusted OR: 2.87, 95% CI: 1.68-4.89). Conclusions: Main motivation to use and duration of phone use are the most important factors predicting problematic smartphone use among medical students.

Role of homoeopathy of Ayush in dengue fever

In 21st century, dengue came to the limelight. Earlier, it was taught that this is one of the eruptive fevers in human beings where in dengue, the eruption appears typically on the 6th day of the fever. Knowledge and approaches to dengue took a paradigm shift in 21st century. It came to be clubbed under the National Vector Borne Disease Control Program. A mosquito borne single stranded RNA virus is the leading cause of arthropod borne viral diseases like dengue globally. All the types of dengue virus are capable of inducing severe diseases like dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). No one wants to be in DHF or DSS stage as these are mortal stages while other stages are morbid. A vector borne disease (VBD) transmitted by mosquito has no specific cure in modern medicine. To add to that, the issue of platelet transfusion that is made universal because of the inherent panic does more harm than good. It is here that homoeopathy has a role to play therapeutically. The article discusses the disease and the related physiology as well as pathology that goes inside the body during an episode of dengue fever. Along with the diagnosis and management approaches, the article elicits the role of homoeopathy through a suggested treatment protocol. Through the inherent properties of homoeopathy such as cost effectiveness, clinical effectiveness and zero side effects, the article proposes large scale application of homoeopathy at all levels.

Mass spectrometry in clinical laboratory: applications and future prospects

Innovations in laboratory medicine face additional challenges due to the unmet need for extremely precise methods of disease diagnosis. Developments in mass spectrometry-based disease biomarker identification are constantly expanding the field of clinical diagnosis. More mass spectrometry-based in vitro diagnostics are anticipated to move from the bench to the bedside shortly, although several are currently incorporated into standard clinical procedures. The molecular detection by mass spectrometry technique is very effective in diagnosis of the disease and therapeutic monitoring because of its extremely high sensitivity, specificity, and short turnaround time. Mass spectrometry is a potent analytical instrument that may be used to analyse a variety of materials and matrices; its use in clinical laboratory medicine applications is rising. For clinical prognostics and diagnostic purposes, mass spectrometry imaging has been widely utilized to distinguish between healthy and diseased tissues. Modern single-cell studies will benefit from its cutting-edge applications, which will offer comprehensive cellular biochemical data for mechanistic comprehension and, eventually, the development of therapeutic interventions. Within the field of laboratory medicine, the application of mass spectrometry is crucial, especially in terms of diagnostics and therapeutic drug monitoring. This review on the clinical application of mass spectrometry and its future prospects promises an insightful exploration of the evolving landscape of mass spectrometry in clinical settings, delving into its current applications and shedding light on its potential future advancements, for which a comprehensive search in the PubMed, ScienceDirect, and Web of Science databases was conducted.

An overview of juvenile ossifying fibroma

Juvenile ossifying fibroma (JOF) is a cancerous bone condition that mainly affects the facial bones, particularly the jaw and upper jaw. This review article provides an overview of JOF, covering its signs, difficulties in diagnosis, radiographic characteristics, histopathological features, and current treatment strategies. The exact cause of JOF is still uncertain, leading to debates about whether it originates from a tumor growth, abnormal development, or reactive response. The way JOF presents clinically can vary greatly, emphasizing the importance of an approach when evaluating patients with facial swellings. Radiographically, JOF appears as a defined area of bone with varying degrees of mineralization. Clinical and histopathological findings must be combined with the results to diagnose this condition accurately. Histopathologically, JOF is characterized by increased tissue and mineralized components that create a two-phase pattern. Surgical treatment options range from removing the affected area to complete resection; however, achieving surgical margins can be challenging and may lead to recurrence due to its ability to infiltrate surrounding tissues. Reconstruction using either bone grafts or artificial materials is necessary for lesions caused by JOF. Long-term follow-up that includes imaging techniques is crucial due to the likelihood of recurrence in JOF cases. Various factors, such as the extent of removal and the aggressiveness of the lesion, influence recurrence rates. Highlight the complexity involved in managing JOF—emerging developments in procedures and understanding at the level offer promising possibilities for focused treatments. A comprehensive approach to managing JOF includes collaboration between healthcare experts, educating patients, and providing support. It is essential to continue research endeavors and promote data sharing to unravel the complexities surrounding JOF, improve precision and treatment approaches, and enhance well-being.

An overview of attention-deficit hyperactivity disorder in the pediatrics

Attention-deficit hyperactivity disorder (ADHD), which is a disorder affecting children worldwide, has lasting effects on their behavior and cognitive functions. This review will explore the complexities of ADHD in children, including its classification, manifestations and management strategies. We will discuss the subtypes of ADHD and how they present challenges in various aspects of a child's life. From difficulties with attention to hyperactivity and impulsivity these subtypes have profiles that impact academic performance, social interactions and emotional regulation. The symptoms of ADHD intertwine inattentiveness, hyperactivity, impulsivity, emotional instability and academic struggles in patients. These symptoms significantly affect a child's functioning across areas such as schoolwork, social life and emotions. To effectively manage ADHD in children requires an approach that combines medication options with interventions, educational support systems tailored to individual needs and parental support programs that emphasize collaboration between healthcare professionals and families. This comprehensive approach seeks to address the requirements of children dealing with ADHD. Its goal is not to reduce symptoms but to improve their long-term outcomes and overall quality of life. By explaining the nature of ADHD in children, this analysis aims to provide an understanding of the disorder. It highlights the significance of customized interventions, early detection, and continuous support in order to enhance the well-being and developmental path of affected children.

Functional recovery in a rare case of an adult patient with leucodystrophy

The adulthood leukodystrophy is an uncommon clinical condition. Physiotherapy treatment provided to this referred patient resulted in a significant functional recovery within a short span of time inspite of gross lesion. A 34-year-old male patient diagnosed as a case of leucodystrophy was referred for Physiotherapy after 2 years of initial diagnosis physiotherapy progress consisted of increasing muscle strength, reducing tightness and improving postural stability; also to improve mobility for 5 months. After taking the pre and post assessment values of MAS, FIST, mFRT and FIM, improvement through the post assessment values showed significant functional recovery within 5 months. Significant functional recovery after 2 years of diagnosis of leucodystrophy provides promising scope of physiotherapy in future cases of leucodystrophy.

Sunlight exposure might account for the relatively low COVID-19 morbidity and mortality in tropical countries

@#The present study aimed at exploring whether sunlight exposure might account for the relative difference in COVID-19-related morbidity and mortality between tropical and non-tropical countries. A retrospective observational study was designed and data from the World Health Organization weekly COVID-19 epidemiological update was compiled. We examined the total number of confirmed COVID-19 cases per 100 000 population, as well as the total number of COVID-19-related mortalities per 100 000 population. Solar variables data were obtained from the Global Solar Atlas website (https://globalsolaratlas.info/). These data were analyzed to determine the association of sunlight exposure to COVID-19-related morbidity and mortality in tropical and non-tropical countries. Results revealed a statistically significant decrease in the number of confirmed COVID-19 cases per 100 000 population (P<0.001), as well as the number of COVID-19-related mortalities per 100 000 population (P<0.001) between tropical and non-tropical countries. Analyses of sunlight exposure data found that specific photovoltaic power output, global horizontal irradiation, diffuse horizontal irradiation and global tilted irradiation at optimum angle were significantly inversely correlated to COVID-19-related morbidity and mortality. This suggests that stronger sunlight exposure potentially leads to lower COVID-19-related morbidity and mortality. Findings from this study suggest that the relatively low COVID-19-related morbidity and mortality in tropical countries were possibly due to better sunlight exposure that translates into adequate vitamin D status.

The bioprotective role of irradiated hibiscus against harmful effects of using repeatedly frying edible oil

Abstract Repeatedly frying process of dietary edible oil has a potential role in the generation of free radicals. Therefore, questions have always been raised as to whether, there is an efficient and economical method to reduce the harmful effects of repeated use of frying edible oil. Since hibiscus has been stated to have a wide variety of therapeutic effects, it was important to investigate its properties against harmful effects of free radicals. The current study aspires to find out whether irradiated powder of hibiscus has a protective role against adverse effects of repeated use of frying edible oil. Thirty-five adult male albino rats were equally assigned into five groups. First groupG1 was fed with normal diet as control group, meanwhile, groupG2 the diet mixed with fresh oil, G3 diet mixed with repeatedly frying oil only, G4 diet mixed with frying oil treated with hibiscus and G5 diet mixed with frying oil treated with irradiated hibiscus. Feeding duration was six weeks. Fatty acid analyses of oil as well as peroxide values were determined. Blood and liver samples were collected for biochemical analyses as well as histological study. Repeatedly heated cooked oil has significant increases in peroxide value, acid value, free fatty acid and both conjugated diene and triene compared with repeatedly frying oil treated with hibiscus. Also there are significant increases in cholesterol and triglyceride and impaired in liver functions in G3compared with others. In addition, relative to the hibiscus groups, there is a substantial reduction in oxygen consumption in G3. Both hibiscus as well as irradiated hibiscus attract attention in order to play a vital and economical role against harmful effects of frequent use of frying edible oil on some biological functions but, irradiated hibiscus was more effective.

Resumo O processo de fritura repetida de óleo comestível da dieta tem papel potencial na geração de radicais livres que podem ter efeitos prejudiciais em algumas funções biológicas. Portanto, sempre se questionou se existe uma maneira eficiente e econômica de prevenir ou pelo menos reduzir os efeitos nocivos do uso repetido de óleo comestível para fritar. Como o hibisco tem ampla variedade de efeitos terapêuticos, foi importante investigar suas propriedades como agente antioxidante contra os efeitos nocivos dos radicais livres. O presente estudo pretende descobrir se o pó irradiado de hibisco tem papel protetor contra os efeitos adversos do uso repetido de óleo comestível para fritar. Trinta e cinco ratos albinos machos adultos foram divididos igualmente em cinco grupos. O primeiro grupo G1 foi alimentado com dieta normal como grupo controle, enquanto o grupo G2 dieta misturada com óleo fresco, dieta G3 misturada com óleo de fritura repetida, dieta G4 misturada com óleo de fritura tratada com hibisco e dieta G5 misturada com óleo de fritura tratada com hibisco irradiado. A duração da alimentação foi de seis semanas. Foram determinadas as análises de ácidos graxos de óleo, bem como os valores de peróxidos. Amostras de sangue e fígado foram coletadas para análises bioquímicas e estudo histológico. O óleo cozido repetidamente aquecido tem aumentos significativos no valor de peróxido, valor de ácido, ácido graxo livre e dieno e trieno conjugados em comparação com óleo de fritura repetidamente tratado com hibisco. Também há aumentos significativos no colesterol e triglicérides e comprometimento das funções hepáticas no G3 em comparação com outros. Além disso, em relação aos grupos de hibiscos, há uma redução substancial no consumo de oxigênio no G3. Tanto o hibisco como o hibisco irradiado chamam atenção por desempenhar papel vital e econômico contra os efeitos nocivos do uso frequente de óleo comestível para fritar em algumas funções biológicas, mas o hibisco irradiado foi mais eficaz.