ABSTRACT
@#Objective To analyze rash and fever illness(RFI) and other respiratory virus co-infection in some confirmed measles cases in Jilin Province from 2013 to 2022,and to provide scientific basis for measles co-infection and multi-pathogen diagnosis.Methods The throat swab specimens of 106 measles confirmed cases in Jilin Province from 2013 to 2022 were collected,of which nine kinds of RFI associated virus and respiratory virus with similar clinical symptoms were detected by fluorescence quantitative PCR,including varicella-zoster virus(VZV),Dengue virus(DENY),human parvovirus B19(HPV-B19),Epstein-Barr virus(EBV),human herpesvirus6(HHV6),human rhinovirus(HRV),respiratory syncytial virus(RSV),human adenovirus(HAdV) and human cytomegalovirus(HCMV),and statistical analysis was conducted by using SPSS 23.0 software.Results VZV and DENV were not detected in the 106 collected specimens,and the other 7viruses were detected.30.18% of the measles cases were co-infected with other viruses,of which only HCMV co-infection cases showed significant difference in the age groups(≤24 months old,24 months old to 15 years old,> 15 years old)(χ~2=9.941,P <0.05);there was no significant difference between the genders in cases co-infected with other viruses(χ~2=0.200—2.778,each P> 0.05).Conclusion Some confirmed cases of measles might be co-infected with one or more other viruses in Jilin Province from 2013 to 2022,and it is recommended to strengthen targeted surveillance and differential diagnosis,especially for infants and young children,women of childbearing age and pregnant women.
ABSTRACT
@#ObjectiveTo analyze the epidemiological regularity of measles in Jilin Province from 2009 to 2022,so as to provide evidence for measles prevention and control measures.MethodsThe representative strains of measles from 2009 to2022 in Jilin Province were sequenced,the dominant epidemic strains and their variation were analyzed by bioinformatics software Bioedit and Mega 11,and the morbidity,immunization history and age distribution of the confirmed cases were analyzed by descriptive epidemiological method.ResultsA total of 6 560 cases of measles were reported in Jilin Province from 2009 to 2022,of which 50. 17% and 27. 58% were cases with zero doses of measles vaccine and unknown immu-nization history,respectively. Children aged 0 ～ 23 months accounted for 47. 29% of the total number of cases,adult group aged ≥15 years accounted for 37. 41%. The reported incidence reached the elimination level of < 1 per million population in the last 3 years due to the impact of immunization strategies and COVID-19 pandemic. The dominant genotype of measles virus in Jilin Province was still H1a genotype. Molecular epidemiological analysis showed that two large transmission chains continued to be prevalent together,one of which was blocked in 2015.ConclusionFrom 2009 to 2022,the reported incidence of measles in Jilin Province showed a downward trend,and the age of the cases showed a "two-way shift" distribution,which was concentrated in the population with no immunization history and unknown immunization history. The basic vaccination rate should be increased continuously,the targeted enhanced immunization should be carried out,and the molecular epidemiological surveillance should be strengthened to block transmission chains in time.