ABSTRACT
An accurate and simple kinetic spectrophotometric method is described for the determination of cefadroxil [CD] and cefoperazone sodium [CPZ] in pure form and in pharmaceutical preparations. The method is based on the reaction of these compounds with potassium permanganate at room temperature in the presence of sodium hydroxide to produce a bluish-green colored product measurable at 610 nm. The proposed method is valid over the concentration range 1-7 micro g/ml and 2-16 micro g/ml for CD and CPZ, respectively, with minimum detectability of 0.12 micro g/ml and 0.001 micro g/ml [3.14x10[-7]M and 1.52x10[-9]M ] for CD and CPZ, respectively. The proposed method was applied successfully for the determination of CD and CPZ in commercial dosage forms and the results obtained are in good agreement with those obtained by the reference methods