ABSTRACT
Introduction: W ith i ncreased a wareness a bout b reast c ancer, d iscovering a b reast l ump c an c ause e motional s tress i n p atients. Thus, diagnostic methods are used to distinguish and confirm benign and malignant breast pathologies. Objective: To characterize the epidemiological profile of the Mastology Clinic of the University Hospital of Maringá, in a period of one year, defining the incidence of benign and malignant breast diseases in patients undergoing breast cancer screenings in the local public health network. Methods: A cross-sectional, retrospective and descriptive study, with data collection from patients seen at the Mastology Clinic from March 2015 to February 2016. Results: Of the 103 patients, 99% were female, 82.3% were between 40 and 69 years old, and 80.5% were white. Regarding the patient's main complaint, 55% had only one altered imaging exam, 7% had only clinical complaints, and 32% had a palpable nodule in addition to an altered imaging exam. The main findings in the imaging exams were nodules, present in 67.1% of mammograms and 80% of mammographic ultrasonography, with inconclusive or suspected classification in 77.9% of mammograms and 65.7% of ultrasonography. Biopsies were performed in 71.8% of the patients. Benign pathologies corresponded to 76.1% of the diagnoses and 25 cases of breast cancer were identified. Conclusion: The epidemiological profile of the Clinic presented similar characteristics to the literature during the period studied. Referrals to specialists were justified because the changes in the imaging exams warranted further investigation. Diagnostic procedures fulfilled their role, differentiating and confirming benign and malignant breast diseases.
Introdução: Com o aumento da conscientização sobre o câncer de mama, descobrir um nódulo mamário pode causar estresse emocional nos pacientes. Dessa forma, métodos diagnósticos são empregados para distinguir e confirmar patologias mamárias benignas e malignas. Objetivo: Caracterizar o perfil epidemiológico do Ambulatório de Mastologia do Hospital Universitário de Maringá, no período de um ano, definindo a incidência de patologias mamárias benignas e malignas em pacientes submetidos a rastreamento de câncer de mama na rede pública regional. Método: Estudo transversal, retrospectivo e descritivo, com a coleta de dados de pacientes atendidos no ambulatório de mastologia de março de 2015 a fevereiro de 2016. Resultados: Dos 103 pacientes, 99% eram mulheres, 82,3% entre 40 e 69 anos e 80,5% da cor branca. Em relação à queixa principal, 55% apresentaram exclusivamente um exame de imagem alterado, 7% apenas queixa clínica e 32% possuíam nódulo palpável além do exame de imagem com alterações. O principal achado nesses exames foram nódulos, presentes em 67,1% das mamografias e 80% das ultrassonografias mamárias, com classificação inconclusiva ou suspeita em 77,9% nas primeiras avaliações e 65,7% nas últimas. Biópsias foram realizadas em 71,8% dos pacientes. Patologias benignas corresponderam a 76,1% dos diagnósticos e 25 casos de câncer de mama foram identificados. Conclusão: O perfil epidemiológico encontrado no ambulatório analisado apresentou características semelhantes à literatura, no período estudado. Encaminhamentos para a especialidade apresentaram justificativa para tal pelas alterações nos exames de imagem que mereciam maior investigação. Procedimentos diagnósticos cumpriram seu papel, diferenciando e confirmando doenças mamárias benignas e malignas.
ABSTRACT
Objective: Analyze the estrogen receptor (ER), progesterone receptor (PR) and HER2 in obese and non-obese postmenopausal patients with breast cancer. Materials and Methods: A retrospective cross-sectional study was carried out in 163 postmenopausal patients with breast cancer at the mastology clinic of the Regional Hospital of Maringá State University and a private mastology clinic from January 2002 to December 2006. A bivariate analysis was used with the non-parametric tests Chi-square and Fishers exact. For obesity calculation, the body mass index (BMI) was used based on the Latin American Obesity Consensus (1999) and on the World Health Organization (1998). Immunohistochemical techniques were performed for ER and PR detection and FISH and CISH methods for HER2 detection. Results: Positive ER in 84 percent of the patients (59 percent in non-obese and 25 percent in obese). A negative result was found in 16 percent of the total of patients (11 percent in non-obese and 5 percent in obese). PR was positive in 76 percent of the total (53 percent in non-obese and 23 percent in obese), and negative in 24 percent (17 percent in non-obese and 7 percent in obese).The overexpression of HER2 was positive in 18 percent (14 percent in non-obese and 4 percent in obese), and negative in 82 percent (56 percent in non- obese and 26 percent in obese).The body mass index cross-comparison with the variables ER, PR and HER2 showed all p-values greater than 0.05 (95 percent CI). Therefore, they are not statistically significant. Conclusions: No significant difference was found between ER and PR among the obese and non-obese patients (p>0.05). No relevant difference was found in HER2 hyperexpression among obese women (p>0.05).
Subject(s)
Female , Adult , Breast Neoplasms , Immunohistochemistry , Obesity , Breast Neoplasms/diagnosisABSTRACT
Os autores fazem uma análise dos resultados histopatológicos de amostras endometriais obtidas de 1.353 curetagens uterinas semióticas realizadas no Hospital das Clínicas da Faculdade de Medicina da Universidade Federal de Minas Gerais. Em 403 casos observou-se que havia algum grau de hiperplasia endometrial. Praticamente näo foram encontradas alteraçöes endometriais graves em pacientes abaixo da faixa etária de 40 anos; entretanto, os casos de hiperplasia adenomatosa com atipias e de carcinoma endometrial foram identificados quase exclusivamente em pacientes com mais de 40 anos. Os autores salientam a importância da avaliaçäo histológica do endométrio em pacientes na faixa etária acima de 40 anos com quadro de hemorragia uterina disfuncional.
Subject(s)
Humans , Female , Adult , Middle Aged , Endometrium/pathology , Uterine Hemorrhage/pathology , Endometrial Hyperplasia/pathology , Endometrial Neoplasms/pathology , ParityABSTRACT
É apresentada uma análise clínico-patológica de 201 casos de tumores de ovário, diagnosticados em pacientes atendidas no Ambulatório de Ginecologia da Faculdade de Medicina da Universidade Federal de Minas Gerais, no período de 1º de janeiro de 1980 a 31 de dezembro de 1988