ABSTRACT
Introduction: Blood transfusion is both a life saving measurein many medical and surgical emergencies and a source oftransfusion transmitted infections. So a provision for strictcriteria in recruitment and deferral of blood donors mayimprove safe transfusion practice. The present study wasconducted to estimate the prevalence of transfusion transmittedinfections in voluntary and replacement donors at a tertiarycare teaching hospital in Indore, Madhya Pradesh,CentralIndia.Material and Methods: The present study was a 4 yearretrospective study from 2015 to 2018. Data was analyzedfrom blood bank records,pertaining to all donors who werescreened for HBsAg, Hepatitis C virus and HIV by usingappropriate methods.Results: A total of 45,704 Voluntary & replacement donorswere screened out of which 44,663 (97.72%) were males &1041 (2.27%) were females. The overall seroprevalence ofHBV & HCV was 1.29% & 0.072% respectively, while theprevalence of HIV was 0.076%.The prevalence rate washighest for HBV followed by HIV and HCV in decreasingorder. The overall seroprevalence of various TTI’s among thestudied donors was 1.43%.Conclusion: Blood is still one of the main sources oftransmission of infections like HIV, Hepatitis B and HepatitisC. Extensive donor selection and screening procedures willhelp in improving the blood safety.