ABSTRACT
The aim of this work was to assess the diagnostic accuracy for neurocysticercosis of ELISA and counterimmunoelectrophoresis techniques, in sera and cerebrospinal fluid. 208 serum samples (47 coming from patients with confirmed cysticercosis) and 87 cerebrospinal fluid samples (27 coming from patients with confirmed cysticercosis) were analyzed. A crude and standardized extract of swine muscle cysticercus cellulosae was used as antigen. ELISA and counterimmunoelectrophoresis had a 100 percent specificity in cerebrospinal fluid, ELISA had a 85.1 percent sensitivity. Cross reactions were observed in sera of patients with confirmed hydatidosis. Thus, the high specificity of both techniques in cerebrospinal fluid is probably due to the low incidence of cerebral hydatidosis in Chile. It is concluded that for the diagnosis of neurocysteicersosis, antibodies against cysticercus cellulosae must be sought paralelly in serum and cerebrospinal fluid using ELISA and counterimmunoelectrophoresis
Subject(s)
Humans , Male , Female , Adult , Counterimmunoelectrophoresis , Cysticercosis/immunology , Enzyme-Linked Immunosorbent Assay , Cysticercosis/complications , Central Nervous System/parasitologyABSTRACT
Se presenta un paciente de 17 años de edad, quien a la edad de 9 años sufre un traumatismo encéfalo craneano (TEC), luego de lo cual queda con sordera derecha. Después de bañarse en una laguna presenta otalgia derecha. Fue tratado con antibióticos y admitido en el Hospital de infecciosos 11 días más tarde. A su ingreso presenta líquido céfalo raquídeo (LCR) purulento. Muere a los 20 días de su ingreso por septicemia, a pesar de su terapia intensiva. La necropsia no muestra evidencia de fractura de peñasco, pero el estudio histopatológico revela una fractura de peñasco con degeneración de laberinto membranoso y pus que pasa del oído medio a través del laberinto hacia el conducto auditivo interno (CAI). Surge la interrogante si el tratamiento quirúrgico, quizás un vaciamiento laberíntico, hubiera modificado la evolución fatal