ABSTRACT
Osteoporosis is a chronic disease characterized by a decrease in bone mineral density [BMD] and corruption of the microarchitectural structure of bone tissue. It was investigated whether methylprednisolone had a favorable effect on osteoporotic bone tissue in Oophorectomy induced osteoporotic rats whose endogenous adrenaline levels are suppressed with metyrosine. Bone Mineral Density, number of osteoblast-osteoclast, bone osteocalcin levels and alkaline phosphatase [ALP] measurements were performed. Obtained results were compared with that of alendronate. Oophorectomy induced osteoporosis was exacerbated by methylprednisolone. Alentronate prevented ovariectomised induced osteoporosis, but it couldn't prevent methylprednisolone +ovariectomised induced osteoporosis in rats. Combined treatment with methylprednisolon and metyrosine was the best treatment for preventing osteoporosis but metyrosine alone couldn't prevent osteoporosis in ovariectomised rats
Subject(s)
Female , Animals, Laboratory , Methyltyrosines , Rats , Osteoclasts/drug effects , Prednisolone , Prednisolone/adverse effects , Drug Combinations , Ovariectomy/adverse effects , Osteoblasts/drug effects , Bone Density/drug effects , Methylprednisolone/adverse effects , Methylprednisolone , Osteocalcin/drug effects , Alkaline Phosphatase , Alendronate , Treatment OutcomeABSTRACT
In this study, we investigated the effects of treatment with chronic antihypertensive drugs [clonidine, methyldopa, amlodipine, ramipril and rilmenidine] on oxidant-antioxidant parameters and toxic effects on DNA in rat uterus tissue. In addition, uterus tissues were examined histopathologically. A total of 36 albino Wistar rats were divided into the following six groups: 0.075 mg/kg clonidine group; 100 mg/kg methyldopa group; 2 mg/kg amlodipine group; 2.5 mg/kg ramipril group; 0.5 mg/kg rilmenidine group; and the healthy group. Rats underwent chronic drug administration for 30 days and at the end, biochemical and histopathological examinations were performed. All data were subjected to one-way ANOVA test. We divided these drugs into the following three groups according to their effects on rat uteri: [I] mild negative effects [clonidine], [II] moderate negative effects [rilmenidine, methyldopa] and [III] drugs which had severe negative effects [amlodipine, ramipril]. These data may help with selection of antihypertensive drugs, in order to determine which drugs have the lowest toxicity in pregnant and non-pregnant [pre-pregnancy] women