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Background: The present study was aimed to evaluate the efficacy of 1.2% Atorvastatin (ATV) with 1.2% Rosuvastatin (RSV) as local drug delivery for treatment of Chronic Periodontitis (CP). Materials and Methods: Forty patients were equally divided into two groups. Group A underwent scaling and root debridement and 1.2% ATV gel (1.2 mg/0.1 mL) was placed, whereas group B received scaling and root debridement and RSV (1.2 mg/0.1 ml) was placed. Results: The results showed that both the groups had improvement in all the recorded parameters, and the results obtained were statistically significant. When comparison was made between the groups, no significant difference was obtained between atorvastatin and rosuvastatin at baseline in all recorded parameters. However, after 6 months significant improvement was recorded in CAL (Clinical attachment level) and PD (Probing depth). The plaque index (PI) and gingival index (GI) score however showed improvement, but it did not attain the level of significance. Conclusion: The present study showed improvement in clinical parameters with the use of ATV and RSV gel when used in combination with scaling and root planing (SRP) in CP patients. Patients with RSV gel showed up significantly better than the ones in which ATV gel was placed.
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Coronavirus disease-2019 (COVID-19) caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) has caused global health crisis. Initially considered a respiratory tract pathogen, it can cause multiple organ dysfunction. It has also been described to predispose to venous and arterial thromboembolism; however, limited published data is available regarding mesenteric thrombosis COVID-19. We report 6 cases of COVID-19 positive patients with mesenteric/intestinal ischemia. These patients were examined with variables including demographics, laboratory blood tests including coagulation panels, medical and surgical history, comorbidities, and postoperative follow-up period.
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Our Objective was to treat a patient having proclined, protruded teeth along with a Class II Skeletal malocclusion. 0.022 × 0.028 inch MBT Brackets were placed, and leveling alignment was commenced. Individual canine retraction was carried out in both arches, followed by retraction of the incisors in the upper arch with a Burrstone's T Loop. E2Z Forsus fatigue resistance appliance was given for the correction of Class II malocclusion. Proclination, protrusion, and crowding were corrected along with Class II Skeletal base. Individual canine retraction along with frictionless mechanics and noncompliant functional correction has sufficient potential to prevent anchor loss and correct a Class II skeletal base.
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Face-masks are currently turning into a fundamental piece of our clothing standard, without a doubt. While the West wasn't entirely ok with face-masks in the pre-COVID-19 period, East Asians were all the more inviting of them. Controlling a respiratory contamination at source by a mask is an entrenched procedure. The utilization of masks followed by certain precautionary measure is a piece of a thorough bundle of the avoidance and control gauges that can restrain the spread of any respiratory viral maladies, including COVID-19. Subsequently the fundamental point of the examination is to illuminate the mask, their utilization and guidelines to be followed during this pandemic period. Numerous nations have suggested the utilization of fabric mask/face covers for the overall population. Right now, the boundless utilization of mask by healthy individuals in the network setting isn't yet upheld by high calibre or direct logical proof and there are likely advantages and damages to consider. Any mask worn for everyday assurance against COVID-19 will be flawed, at any rate for the current pandemic time.
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Breast cancer is a type of tumor in which individual cases deviate from each other in morphology, protein expression, molecular phenotype, genetic characteristics, and prognosis. Worldwide, breast cancer is the most-common invasive cancer in women. A patient with breast cancer may have the following symptoms:-lumps, skin dimples, nipple discharge, nipple height, nipple withdrawal, pain and burning sensation. There are many causes and risks of breast cancer, including family history (heriditary), obesity, active smoking, early and late childbearing, breastfeeding for less than two weeks, exposure to estrogen and oral contraceptive pills. Most breast cancers are diagnosed through estrogen receptor (ER) -positive determination and rely on estrogen for cell growth and survival. Breast cancer treatment has encountered a few progressions in the previous decades with the revelation of explicit prescient prognostic biomarkers that make conceivable the use of individualized treatments.Blocking estrogen biosynthesis by aromatase inhibitors (AI) has, subsequently, become a first-line endocrine treatment for menopausal ladies with ER-positive breast disease. Various conventional diagnosing and treating methods of breast cancer is available but there have limitation of accuracy and treating. For that reason now a day’s various biomarkers like Molecule or Biochemical biomarkers like Estrogen receptor, Progesterone receptor, human epidermal growth factor receptor 2 (HER2), human Mammaglobin(H-MAM), Osteopontin, Fibroblast Growth Factor Receptor 2 (FGFR2), Phosphatase and tensin homolog (PTEN), Physiologic Biomarkers like Carcinoma Antigen 15-3(CA 15–3), Cancer Antigen 125 (CA 125), Prostate specific antigen (PSA) and Anatomic Biomarkers Oncotype Dx, and Cystic fibrosis Trans-membrane conductance regulator(CFTR). These biomarkers are of great importance in the evaluation and diagnosis process, which leads to better patient’s care and protection of the patients. Due to its various advantages, biomarkers are considered as an innovative tool in the progression of breast cancer diagnosis and treatment.
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Background: Aim of the study was to evaluate the role of NST (labour admission test) as a screening method in management of low risk pregnancies and to study the correlation of NST with fetal outcome.Methods: A prospective observational study conducted over 500 patients managed at our centre after proper evaluation. Patients were evaluated for mode of delivery and neonatal outcome.Results: The maximum number 352 of patients belonged to 20-30 years age group, 113 patients belonged to 31-35 age group. 200 patients were of 37-40 weeks gestation and 185 were of 40-41 weeks gestation. There were 125 patients in the 41-42 weeks gestational period. Among the 500 pregnant mothers who were included in the study 82.6% had Normal NST, 11.6% had suspicious and 5.8% had pathological NST. Cesarean rate was 14.4% in normal NST group, 58.62% in suspicious group and 72.41% in pathological group study. 6.77% in Normal group had meconium stained liquor at delivery whereas 29.31% in suspicious group and 37.93% in pathological group had same.Conclusions: The non-stress test is an important screening tool to identity the fetus in jeopardy in utero. This enables an appropriate timely intervention to achieve the most favorable outcome.
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The present study analyzed the clinical significance of duration of intra-abdominal hypertension (IAH) associated with increased serum lactate in critically ill patients with severe sepsis. Materials and Methods: Our study was an observational, prospective study carried out in the Surgical Intensive Care Unit (ICU) at J.L.N Medical College, Ajmer, Rajasthan, India. In our study, we included a total of 100 patients and intra-abdominal pressure (IAP) was measured through intravesical route at the time of admission and after 6, 12, 24, 48, and 72 h via a urinary catheter filled with 25 ml of saline. Duration of ICU and hospital stay, need for ventilator support, initiation of enteral feeding, serum lactate level at time of admission and after 48 h, and 30-day mortality were noted asoutcomes.Results:In our study, an overall incidence of IAH was 60%. Patients with cardiovascular surgery and renal and pulmonary dysfunction were 93.3%, 55%, and 60%, respectively, at the time of admission and 65%, 10%, and 10%, respectively, after 72 h of admission in the surgical ICU. Nonsurvivors had statistically significant higher IAP and serum lactate levels than survivors. Patients with longer duration of IAH had longer ICU and hospital stay, longer duration of vasopressors and ventilator support, and delayed enteral feeding.Conclusion:There is a strong relationship "risk accumulation" between duration of IAH associated with increased serum lactate and organdysfunction. The duration of IAH was an independent predictor of 30-day mortality. Early recognition and prompt intervention for IAH and severe sepsis are essential to improve the patient outcomes
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Intra-Abdominal Hypertension , Lactates , Sepsis , SerumABSTRACT
Thoracic trauma contributes to one-quarter of trauma deaths. Traumatic hemothorax is commonly associated with organ damage, such as rib fracture, lung injury, and diaphragm rupture and usually occurs immediately after trauma. Here, we report the case of an 18-year-old male patient of a road traffic accident. He was admitted with an open chest wound and fractured ribs with exposed heart, left hemidiaphragm, left lung, and left thoracic cavity. He had fractured lower ribs with the contusion of intercostal and pectoral muscles. The wound was explored proper toileting of the wound, and the left chest cavity was done. A tear in the left lung was repaired, ribs were positioned, and the chest wall was reconstructed without using any prosthesis. In the post-operative period, the patient developed partial flap necrosis and so he was referred to plastic surgery where debridement and pedicled latissimus dorsi flap were applied. The patient got discharge after about 1 month of the post-operative period.
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Aortopulmonary window is a rare congenital anomaly with a communication between ascending aorta and main pulmonary artery. It may be associated with other cardiac malformations like aortic arch anomalies, ventricular septal defect, tetralogy of fallot etc. Survival beyond infancy is rare and early surgical intervention is important to prevent development of irreversible pulmonary hypertension. We report a rare case of larger Aortopulmonary window along with a large ventricular septal defect presenting at the age of 16 years.
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Background: Hypertension has been identified as the leading risk factor for mortality. Therefore, the present study has been taken up to find out the relation between anthropometric indices, blood pressure and hypertension so as to identify the population under risk. Methods: The present study was done on 600 male students of age group 16-27 years belonging to FH Medical College, Tundla, Firozabad and St. Andrew`s college, Agra. The anthropometric measurements of the subjects were taken with the slandered instruments with standard techniques described as Height (mt), Weight (Kg), Waist Circumferences (cm), Hip Circumference (cm), Pulse rate Radial pulse felt and counted at wrist for 1 minute. Results: In the present study 43% students were found under low level of stress and more levels of stress were seen in 6%. The prevalence of pre-hypertension was found 69% while hypertension was found 5.75%. Conclusion: Strong association of faulty dietary history, sedentary life style and genetic history was seen with blood pressure.
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Introduction: Obesity is a worldwide health issue, associated with excessive fat accumulation in the body to the extent that health and well-being are adversely affected. Obesity may increase the risk of many diseases such as diabetes, atherosclerosis, hypertension dyslipidemia, gallbladder diseases and cardiovascular diseases. Anthropometric measurements can easily reflect any changes in the lipid concentration in the human body. Intra-abdominal fat has been identified as being the most clinically relevant type of fat in humans. Abnormal visceral fat produces physiological changes that alter lipid profile, leading to dyslipidemia, which in turn increases the risk of cardiovascular events. Body mass index, waist and hip circumferences were found to be useful anthropometric predictors for cardiovascular risk. The aims and objectives of the study are Body mass index, waist and hip circumferences were found to be useful anthropometric predictors for cardiovascular risk. To evaluate the correlation between lipid profiles and anthropometric indices of total and central obesity. Methods: The present study was conducted among 90 adults (45 male, 45 female) in FH Medical College. All subjects were apparently healthy. The serum lipid profile included total cholesterol (TC), highdensity lipoprotein (HDL), low-density lipoprotein (LDL) and triacylglycerols (TG). BMI (kg/m2) was calculated using Quitelet’s index. Adults were classified according to their BMI into three groups. Results: Average age of males is 40.02 years and females 36.46 years. On the basis of BMI, there was 14.44% of normal weight persons, 26.67% overweight and 58.89% obese. Abnormal levels for TG in 35, TC in 20, LDL in 3, HDL in 27 of the total sample were found. Overall correlations were found between anthropometric analysis and lipid profiles. Conclusion: We found good correlations between anthropometric indices of general and central obesity and lipid profiles. Among, the anthropometric indices WHR proved to be a good predictor of dyslipidemia, showing the importance of using it in clinical practice and for screening of cardiovascular risk. Prospective studies using different parameters to assess abdominal obesity and its relationship to metabolic profile and with larger population are needed to quantify the results for application to community health lifestyle modifications.
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Aim: This study was to determine the distance between IOF and IOM, IOF and pyriform aperture,the presence of accessory foraminae, orientation and location in relation with teeth on both the sides. Materials and Methods: Fifty dried human skulls (100 sides) irrespective of age and sex were used for this study. The distance between the IOF and IOM and the distance between the IOF and pyriform aperture were measured by using manual vernier calliper. The orientation, location in relation with teeth and presence of accessory foramina were observed macroscopically. Observations and Discussion: Accessory foramina may give complications during anaesthetization of this region. The mean distance between the IOF and infraorbital margin was 22.6mm and 15.2mm on the left and right side respectively. Mean distance between I.O.F and pyriform aperture was 26.2mm and 25.8mm on the left and right side respectively. In 30% skulls the IOF were directed vertically downward on the right side and in 38% on the left side. In 66% downward medially on the right side and 56% on the left side and in4% skulls medially on the right side and 6% on the left side. The majority of IOF were oriented to second premolar teeth on the right side and between second premolar and first molar on the left side.Accessory foraminae were found in 6% of skulls. The results of our study may be helpful during surgical procedures in the maxillary region in reduction of Lefort fracture, and giving regional nerve block.
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The foramen magnum is an important landmark located in the posterior part of the cranial base formed by the occipital bone. The purpose of this study was to evaluate the measurements of the foramen magnum in human dried skull and to note the variations in the shape and size of the foramen magnum. Additionally area and index of the foramen magnum were also calculated. Fifty human dried skulls of unknown age and sex were obtained from the department of CMCH Bhopal and FHMC Tundla. Foramen magnum were examined macroscopically for their different shapes. Anteroposterior and transverse diameters, foramen magnum area & foramen magnum index were measured. The foramen magnum shapes were determined as round shaped in 22%, oval shaped in 16%,egg shaped in16%, and irregular in18%,tetragonal in 12% penta and hexagonal 8% each. The mean A-P and transverse diameters of the foramen magnum was determined 38.75mm and 33.44mm respectively. In 4%of skull, the occipital condyle was observed to protrude in to the foramen magnum. The mean foramen index and foramen magnum area were 87.68 & 970.57mm². The data obtained may be useful to the neurosurgeon in analysing the morphological anatomy of craniovertebral junction in trans condylar approach for brain stem lesion.
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Background & objectives: Osteoarthritis (OA) is a degenerative disease characterized by joint pain and progressive loss of articular cartilage. Entada pursaetha has been traditionally used in the treatment of inflammatory disease, liver ailment, etc. In this study we investigated suppressive effect of ethanolic extract of E. pursaetha (EPE) on monosodium iodoacetate (MIA)-induced osteoarthritis pain and disease progression by histopathological changes in joints in a rat model. Methods: OA was induced in right knee of rat by intra-articular injection of 3 mg of MIA and characterized by pathological progression of disease and pain of affected joint. Spontaneous movements, mechanical, thermal and cold sensitivity were monitored at days 0 (before drug and MIA injection), 7, 14 and 21 of MIA administration. EPE (30, 100 and 300 mg/kg), vehicle or etoricoxib (10 mg/ kg; reference drug) were administered daily for 21 days by oral route. Results: EPE at various doses significantly reduced mechanical, heat, cold hyperalgesia and increased the horizontal and vertical movements in intra-articular MIA injected rats. EPE prevented the damage to cartilage structure and reduced the cellular abnormalities. Articular cartilage of rats treated with EPE at 300 mg/kg group was almost normal with well-developed smooth surface and chondrocytes were distributed individually or arranged in column. Interpretation & conclusions: the present findings showed that the EPE was not only able to mitigate pain and hyperalgesia but also inhibited MIA-induced cartilage degeneration in vivo. EPE may have the potential to become therapeutic modality in the treatment of osteoarthritis. However, further studies need to be done to confirm these findings in other models and clinical trials.
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Background: Extraction of all 1st premolars in the orthodontic treatment of Class II div 1 malocclusion has been associated with a decrease in vertical dimension of occlusion thus predisposing the patient to TMJ disorders. Objectives: To evaluate the vertical changes occurring in patients having class II div 1 malocclusion, treated orthodontically with 1st premolar extractions & compare these changes with those occurring in patients treated orthodontically without extractions. Method: Pre-treatment & Post-treatment Lateral Cephalogram radiograph of 11 patients having CL-II div1 malocclusion treated without extraction and 16 patients treated with the extraction of all 1st premolars were analyzed and compared to observe the changes in the anterior facial height. Result: the orthodontic treatment of Cl-II div 1 malocclusion cases treated with a non-extraction approach leads to a statistically significant increase in the anterior facial height due to the downward & backward rotation of the mandible. The cases treated with the extraction of all 1st premolars also show the statically significant increase in the anterior facial height but this increase was less than that observed for the non-extraction group. Conclusion: this study does not support the theory that the first premolar extractions reduce the vertical dimension of occlusion and predispose the extraction patients to TMJ disorders.
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Malaria is considered endemic in 104 countries and territories around the world nessessitating its control. Essential oils belonging to various plant species and possessing mixtures of hydrocarbons have been seen to act as effective repellent against various pests. The monoterpenoids constituting the major component is found to be cytotoxic to plant and animal tissue thus impairing the normal functioning of these tissues. The commercially marketed repellents basically consist of essential oils from plants Cymbopogon nardus, Eucalyptus maculata, Cymbopogon excavatus, Mentha piperita, Azadirachta indica. The volatile nature of these components due to their short duration of efficacy has urged for the development of novel formulations, use of fixatives such as vanillin and combination essential oil plants as repellents. The easy availability and less adverse environmental impact have led to the increased interest in plant origin insecticides as an alternative to chemical insecticides. The present article envisaged to review the reports of essential oils on its effectiveness as repellent.
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Anal stenosis is a rare but serious disabling condition following ano rectal surgery, anal trauma, carcinoma, post radiotherapy and Crohn's disease. 90% of the anal stenosis is causes by overzealous haemorrhoid surgery. Stricture following sclerotherapy is also mentioned in the literature. In our cases disabling anal stenosis was for last 1 year following sclerotherapy of haemorrhoids leading to severe anal stenosis with diaphragmatic ring like annular stenosis. A formal Y-V anoplasty was performed which relieved the patients of their symptoms leading to satisfactory bowel movements.
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Much Research has been going to find ideal system for drug delivey within body.It is great advantage to find drug delivery device that is capable of controlled or continous release of wide variety of drug.Microchip are provided, which control both the rate and the time release of molecule.This allows release of wide variety of molecule in either continous or pulsatile manner. The device consist of substrate containing multiple reservoir is capped with conductive membrane (gold) and wired with final circuitry controlled by microprocessor.Reservoir are etched into substrate using either chemical etching or ion beam etching techniques. Hundreds to thousands reservoirs can be fabricated on a single microchip using microfabrication.The molecule to be delivered are inserted into reservoir by injection. The reservoir can contain multiple drug or other molecule in variable dosages. The filled reservoirs can be capped with material that degrade or allow the molecule to diffuse out of reservoir over time or materials that oxidize and dissolve upon application of electric current.Release from an active device can be controlled by a preprogrammed microprocessor.It is used in diabetes, Parkinson’s disease, congestive heart failure, anti coagulation.