ABSTRACT
Abstract Cutaneous metastases from solid tumors are uncommon events in clinical practice. Most of the time, the patient already has the diagnosis of a malignant neoplasm when the cutaneous metastasis is detected. However, in up to one-third of cases, cutaneous metastasis is identified before the primary tumor. Therefore, its identification may be essential for starting treatment, although it is usually indicative of poor prognosis. The diagnosis will depend on clinical, histopathological, and immunohistochemical analysis. Sometimes the identification of the primary site is difficult; however, a thorough analysis using imaging tests and constant surveillance is important.
Subject(s)
Humans , Skin Neoplasms/epidemiology , Melanoma/epidemiology , Prognosis , Sex Factors , Retrospective StudiesABSTRACT
Abstract Systemic amyloidosis secondary to psoriatic arthritis is rare, and published data are based mainly on case reports and are associated with increased mortality. This is the report of a patient with long-term psoriatic arthritis and chronic sialadenitis, who showed an inadequate response to therapy. The diagnosis of secondary amyloidosis was attained through biopsies of genital skin lesions. Although very rare, it is important that dermatologists and general practitioners consider the possibility of amyloidosis in patients with chronic inflammatory diseases, since an early intervention can be implemented, and thus, the prognosis of this condition can be improved.
Subject(s)
Humans , Psoriasis , Arthritis, Psoriatic/complications , Immunoglobulin Light-chain Amyloidosis , Amyloidosis/complications , Amyloidosis/diagnosis , SkinABSTRACT
Abstract Sporotrichosis is a deep mycosis of subacute or chronic evolution, caused by the dimorphic fungus of the genus Sporothrix. The treatment is carried out with antifungal orally or intravenously. Therapeutic success can be affected by several factors, such as altered gastrointestinal physiology by surgery. More and more patients are submitted to bariatric surgeries and the literature for the alterations of the absorption of medications in this context is very scarce. We intend to contribute to a better understanding with this case report of cutaneous-lymphatic sporotrichosis in a patient after bariatric surgery without response to itraconazole treatment, even at high doses.
Subject(s)
Humans , Female , Adult , Sporotrichosis/drug therapy , Itraconazole/therapeutic use , Bariatric Surgery/adverse effects , Antifungal Agents/therapeutic use , Sporotrichosis/pathology , Treatment Failure , Gastrointestinal AbsorptionABSTRACT
Abstract The Borst-Jadassohn phenomenon is a morphological finding that consists of the presence of well-defined nests of cells located in the spiny stratum of an acanthotic epidermis. One of the neoplasms where this phenomenon is found is hidroacanthoma simplex. This neoplasm is considered the intraepidermal form of the eccrine poroma. Despite its benign nature, malignant transformations are reported. The present article reports a case of hidroacanthoma simplex and discusses the dermoscopy of this phenomenon.
Subject(s)
Humans , Female , Aged, 80 and over , Skin Neoplasms/pathology , Skin Neoplasms/diagnostic imaging , Acanthoma/pathology , Acanthoma/diagnostic imaging , Biopsy , Dermoscopy/methods , Epidermis/pathology , Epidermis/diagnostic imagingABSTRACT
Abstract: Squamoid eccrine ductal carcinoma is a cutaneous malignancy that originates from the eccrine sweat gland. A 76-year-old woman presented with an asymptomatic papule on her nose that had been present for one year. Dermoscopy showed pseudocysts, irregular linear crown vessels, and yellowish-brown globules surrounded by white halos. This is the first dermoscopic description of squamoid eccrine ductal carcinoma. Studies with more cases are needed to confirm the dermoscopic characterization of this tumor.
Subject(s)
Humans , Female , Aged , Skin Neoplasms/pathology , Carcinoma, Squamous Cell/diagnosis , Eccrine Glands/pathology , Skin Neoplasms/surgery , Skin Neoplasms/diagnosis , Immunohistochemistry , Carcinoma, Squamous Cell/surgery , Carcinoma, Squamous Cell/pathology , Early Diagnosis , Dermoscopy , Diagnosis, Differential , Eccrine Glands/surgerySubject(s)
Humans , Male , Middle Aged , Soft Tissue Neoplasms/pathology , Glomus Tumor/pathology , Skin/pathology , Soft Tissue Neoplasms/diagnosis , Bone Diseases/diagnosis , Bone Diseases/pathology , Glomus Tumor/diagnosis , Subcutaneous Tissue/pathology , Diagnosis, Differential , Knee , Muscular Diseases/diagnosis , Muscular Diseases/pathologyABSTRACT
Leprosy is aneasily recognizable disease due to its dermato-neurological manifestations. It must be present in the physician’s diagnostic repertoire, especially for those working in endemic areas. However, leprosy reaction is not always easily recognized by non-dermatologists, becoming one of the major problems in the management of patients with leprosy, as it presents clinical complications characterized by inflammatory process, accompanied by pain, malaise and sometimes the establishment or worsening of the patient’s disabilities. We report the case of a patient with type-1 periorbital reaction admitted to the hospital, diagnosed and treated as facial cellulitis, whose late diagnosis may have contributed to the appearance or worsening of facial neuritis.
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