Comparison of efficacy and safety of topical 0.1% tacrolimus ointment versus 0.1% mometasone furoate ointment in mild to moderate chronic hand eczema

Objectives: to evaluate the therapeutic efficacy and safety of 0.1% tacrolimus ointment versus mometasone furoate 0.1% ointment in mild to moderate chronic hand eczema

Methods: it was a randomized control trial carried out in dermatology department unit-II, KEMU/ Mayo Hospital, Lahore. Patients with mild to moderate chronic hand eczema were enrolled with age range between 18-70 years, of either sex. We randomized the patients in two groups A and B by balloting. Group A used tacrolimus 0.1% ointment twice daily for 6 weeks. Group B used mometasone furoate 0.1% ointment twice daily for 6 weeks. The data were collected and analyzed by SPSS version 18 and p-value <0.05 was taken as significant

Results: the study was completed by 102 patients, with 51 in each group, with mean age of 32 years and majority were married females. Both the treatment options were found to be equally efficacious with PGA Score showing significant p value at the end of study [p-value = 0.042]. The side effects noted were itching and irritation. Irritation was observed in both treatment groups but did not lead to discontinuation of the treatment, as it was transient. This complaint was seen more among the Group A patients

Conclusion: it is concluded from our study that 0.1% tacrolimus ointment and 0.1% mometasone furoate ointment are equally efficacious and safe in the treatment of mild to moderate chronic hand eczema

outcome comparison of the open Vs closed haemorrhoidectomy: a quasi-experimental study in tertiary care hospital

Objective: to compare open and closed haemorrhoidectomy for wound healing time, hospital stay and complications

Material and Methods: sixty patients fulfilling the inclusion criteria were selected for this study and divided into two groups. Group A was treated by open haemorrhoidectomy and group B by closed haemorrhoidectomy. Postoperatively patients were evaluated for wound healing time, hospital stay, early and late complications

Results: the mean wound healing time in closed haemorrhoidectomy group was 2.60+/-0.67 weeks. The mean wound healing time in op n haemorrhoidectomy group was 3.97+/-0.76 weeks. There were 2 [6.7%] patients of urinary retention in closed haemorrhoidectomy group and no patient in open haemorrhoidectomy group. There were 29 [96. 7%] patients of mild to moderate bleeding and 1 [3.3%] patient of severe bleeding in closed haemorrhoidectomy group. In open haemorrhoidectomy group, 1[3.3%] patient had no bleeding, 28 [93 .3%] patients had mild to moderate bleeding and 1 [3.3%] patient had severe bleeding. Among late complications at one month follow up, 1 [3.3%] patient developed anal stenosis in closed haemorrhoidectomy group. In open haemorrhoidectomy group there was 1 [3.3%] patient of anal stenosis and 1 [3.3%] patient of anal fissure

Conclusion: open haemorrhoidectomy has more reliable wound healing with lesser complications, though complete wound healing time is more as compared to the closed technique