ABSTRACT
Extra-amniotic pregnancy, which is caused by rupture of amniotic membranes only, is a rare event during pregnancy. This differs from extra-membranous pregnancy in which both chorionic and amniotic membranes rupture. Extra-amniotic pregnancy requires attention by an obstetrician not to miss fetal anomalies because extra-amniotic pregnancy may accompany with fibrous band syndrome. We experienced a case of extraamniotic pregnancy with congenital amputation of bilateral fetal hands. And we report it with brief review of literatures.
Subject(s)
Infant, Newborn , Pregnancy , Amnion , Amniotic Band Syndrome , Amputation, Surgical , Chorion , Hand , Pregnancy Complications , RuptureABSTRACT
Extra-amniotic pregnancy, which is caused by rupture of amniotic membranes only, is a rare event during pregnancy. This differs from extra-membranous pregnancy in which both chorionic and amniotic membranes rupture. Extra-amniotic pregnancy requires attention by an obstetrician not to miss fetal anomalies because extra-amniotic pregnancy may accompany with fibrous band syndrome. We experienced a case of extraamniotic pregnancy with congenital amputation of bilateral fetal hands. And we report it with brief review of literatures.
Subject(s)
Infant, Newborn , Pregnancy , Amnion , Amniotic Band Syndrome , Amputation, Surgical , Chorion , Hand , Pregnancy Complications , RuptureABSTRACT
Twin Pregnancies are increasing these days due to recent development of the technology in treating infertility. twin pregnancies tend to cause more congenital anomalies than singleton pregnancies do. Especially when twin pregnancies are affected with one anomalous fetus combined to a normal one, the proper management and counseling are difficult. We experienced a twin pregnancy in which one anencephalic fetus was combined to a normal one, after close counseling we decided to continue the pregnancy. At 35 weeks 6 days of gestation, an anencephalic fetus was dead, so we delivered by cesarean section due to breech-cephalic presentation. The birth weight of the normal and anencephalic fetuses were 2160 gm and 600 gm, respectively. The anencephalic fetus was combined with scoliosis, absent left upper limb, and nuchal skin defect, but the healthy one showed good crying and movement and its Apgar score was 8 in 1 minute and 9 in 5 minute. Although the infant needed intensive care for 21days in the nursery room, she was finally discharged in good condition. We present this case with a brief review of the literature.
Subject(s)
Female , Humans , Infant , Pregnancy , Anencephaly , Apgar Score , Birth Weight , Cesarean Section , Counseling , Crying , Fetus , Infertility , Critical Care , Nurseries, Infant , Pregnancy, Twin , Scoliosis , Skin , Twins , Upper ExtremityABSTRACT
OBJECTIVE: Telomerase is a ribonucleoprotein that synthesizes TTAGGG repeats onto chromosome ends. The expression of telomerase is thought to be required for cellular immortality and carcinogenesis. This study was conducted to examine the telomerase activation occurs in cervical carcinogenesis. METHODS: The standard telomeric repeat amplification protocol(TRAP) was used to examine telomerase activity in tissues of 10 normal cervix, 10 carcinoma in situ, and 21 invasive cervical carcinoma. RESULTS: Telomerase activity was detected in tissues of 16/21(76.2%) invasive carcinoma, in 5/10(50.0%) carcinoma in situ, and in 3/10(30.0%) normal cervix. But the degree of telomerase activity in normal cervix was weak. There was significant difference in 3 groups(p<0.05). The results of neoadjuvant chemotherapy in 10 invasive cervical carcinoma were as follows. In 8 cases of which tumor size decreased more than 50%, 5 were positive for telomerase. In 2 cases that didn't respond to chemotherapy by tumor size, 1 was positive for telomerase. There was no significant difference between 2 groups. All of the 5 cases that had pelvic lymph node metastasis revealed positive telomerase activity, and the 11 cases of 16 cases that didn't have pelvic lymph node metastasis were positive for telomerase, but there was no significant difference in 2 groups. The positivity of telomerase activity in clinical stage of invasive cervical carcinoma was 73.3% in stage I(11/15), 75.0% in stage II(3/4), 100% in stage III(1/1), and 100% in stage IV(1/1), but there was no significant difference in each stages. CONCLUSION: Telomerase seems to be uniquely associated with malignant transformation of cervix and can be used as a tumor marker. Additional studies are needed to better clarify the biological significance of telomerase expression in cervical tumorigenesis.