1.
Article
in English
| IMSEAR
| ID: sea-20119
ABSTRACT
Single oral doses of 10 to 160 mg centpropazine, a new antidepressant (synthesized by CDRI, Lucknow, India) were administered to groups of 4-5 male volunteers, each dose being interspersed with placebo in a double blind, non-crossover study by random distribution. The drug was well tolerated. Drowsiness, heaviness, weakness and/or headache were reported only at doses of 120 mg and above. No adverse effect was noted in various laboratory tests, ECG or vital parameters. In a multiple dose study, volunteers received 40 or 80 mg centpropazine daily for 4 wk. Mild restlessness and insomnia were observed in some subjects receiving 80 mg dose. In this study also no effect was observed in various laboratory tests, ECG or vital parameters.
Subject(s)
Adolescent , Adult , Aged , Antidepressive Agents/adverse effects , Dose-Response Relationship, Drug , Double-Blind Method , Drug Evaluation , Drug Tolerance , Humans , Male , Middle Aged , Piperazines , Random Allocation
2.
Indian J Exp Biol
;
1982 Apr; 20(4): 344-6
Article
in English
| IMSEAR
| ID: sea-62066
3.
Indian J Exp Biol
;
1977 Dec; 15(12): 1131-3
Article
in English
| IMSEAR
| ID: sea-62167
Subject(s)
Adolescent , Adult , Clinical Trials as Topic , Double-Blind Method , Humans , Hypnotics and Sedatives , Male , Middle Aged , Quinazolines/pharmacology , Tranquilizing Agents
4.
Indian J Exp Biol
;
1973 Sep; 11(5): 459-60
Article
in English
| IMSEAR
| ID: sea-63343
Subject(s)
Aged , Blood Cell Count , Blood Platelets , Humans , Leukocyte Count , Leukopenia/blood , Methods , Middle Aged , Neoplasms/blood
5.
Indian J Exp Biol
;
1973 May; 11(3): 188-90
Article
in English
| IMSEAR
| ID: sea-57861
Subject(s)
Animals , Blood Protein Electrophoresis , Blood Proteins/analysis , Cestoda/immunology , Hymenolepiasis/blood , Male , Precipitins , Rabbits/immunology , Rats
6.
Indian J Exp Biol
;
1973 May; 11(3): 183-7
Article
in English
| IMSEAR
| ID: sea-61651
7.
Article
in English
| IMSEAR
| ID: sea-23638