ABSTRACT
Objective To investigate the clinical characteristics and related factors of diagnosis and treatment of patients with hypertensive cerebral hemorrhage,and provide basis for clinical treatment and prognosis.Methods The clinical diagnosis and treatment data of 96 patients with hypertensive cerebral hemorrhage,admitted to our hospital from February 2010 to February 2013,were analyzed.Results In all the 96 patients,improvement was noted in 76 accounting for 79.17％,limb paralysis in 74 accounting for 77.08％ and death in 17 accounting for 17.71％; death within 24 hours of onset was noted in 11 accounting for 11.46％ and within 24-72 hours in 6 accounting for 6.25％.Automatic discharge was observed in 3,accounting for 3.13％.Conclusion Choosing corresponding treatments according to the hematoma sizes in patients with hypertensive cerebral hemorrhage plays important role in improving the prognosis.
ABSTRACT
Objective To investigate the correlation between asymmetric dimethylarginine (ADMA) and endothelial dysfunction in patients with type 2 diabetic nephropathy.Methods The 81 patients with type 2 diabetic nephropathy were selected.According to the urinary albumin excretion rate (UAER),the patients were divided into micro-albuminuria group (DN1 group,UAER 21-199 mg/24 h,38 cases) and macro-albuminuria group (DN2 group,UAER ≥ 200 mg/24 h,43 cases).The 20 healthy people were defined as control group.Intimal-media thickness and endothelial dysfunction of the radial artery of right forearm were detected by color Doppler ultrasound.The serum level of ADMA was determined by enzyme-linked immunosorbent assay.Results There was no significant difference in radial artery inner diameter intimal-media thickness among the 3 groups (P ＞ 0.05).The Endothelial dependent diastolic function (EDD) and endothelial independent diastolic function (EID) in DN1 group and DN2 group were significantly lower than those in control group [(10.45 ± 2.58)％ and (7.56 ± 2.17)％ vs.(15.72 ± 3.05)％,(15.42 ± 2.71)％ and (15.37 ± 2.92)％ vs.(19.31 ± 3.76)％,P ＜ 0.05],and the EDD in DN2 group was significantly lower than that in DN1 group (P＜ 0.05).The serum ADMA in DN1 group and DN2 group was significantly higher than that in control group [(0.63 ± 0.08) and (0.92 ± 0.12) μ mol/L vs.(0.39 ± 0.05)μmol/L,P ＜0.05],and in DN2 group it was significantly higher than that in DN1 group (P ＜0.05).In patients with type 2 diabetic nephropathy,the serum ADMA and EDD had negative correlation (r =-0.81,P =0.020),but the serum ADMA and C reactive protein had positive correlation (r =0.75,P =0.034).Conclusions The serum level of ADMA is significantly increased in patients with type 2 diabetic nephropathy.There is a close correlation between ADMA and endothelial dysfunction of artery.