effect of pentoxifylline in semen preparation for intrauterine insemination

Pentoxifylline [PX] is a methyxanthin derivative that influences the sperm motility characteristics. and has been reportedly effective in preserving sperm motility in vitro. This study was undertaken to evaluate whether addition of pentoxifylline to the previously standardized in-vitro treatment of semen improves the percentage of pregnancies after homologous IUI. The study involved 110 infertile couples [66 classified infertile for male factors and 44 for other factors] who underwent a total of 300 cycles of homologous IUI: 202 for male factor infertility and 98 for other factors. Out of the 202 cycles performed for male factor infertility, 122 underwent the standard preparation of semen, pregnancy rate were 11.5%. While 80 had a semen preparation with pentoxifylline. The pregnancy rate were 27.5% better with pentoxifylline preparation [P<0.05]. Abortions and malformations were equally distributed in the standard treatment and in the pentoxifylline group. Our results demonstrate that pentoxifylline may be used for improving the male infertility treatment program

effect of cigarette smoking on semen quality of infertile men

To evaluate the effects of cigarette smoking on semen quality of infertile men. Two hundred fourteen infertile men who had been smoking cigarette and one hundred thirty infertile non smokers' men participated in this study. Seminal volume, sperm concentration, motility, viability, and morphology were examined. The quality of spermatozoa obtained from smokers were much lower than non-smokers [P<0.01]. The sperm concentration, viability and forward progression were negatively correlated with cigarette smoking [P<0.01]. Smoking does affect the semen quality of infertile men

relationship between total motile sperm count and pregnancy rate after intrauterine insemination

To determine the relationship between the total motile sperm count and the success of IUI treatment cycles with postwashed husband spermatozoa in couples with infertility in a large patient population. Retrospective descriptive study. Academic University Hospital- based infertility center. Eight hundred twenty four infertile couples undergoing 824 cycles of IUI. outcome measure[s]: To assess the significance of prognostic factors including a woman's age, duration of infertility, diagnoses, use of ovulation induction and sperm parameters for predicting the outcomes of clinical pregnancy after the first cycle of IUI. The pregnancy rate per cycle was 18.2% [150/824]. Postwashed semen parameters including total motile sperm count >10'106, motility >50%. There was a trend toward an increased success rate with increased total motile Sperm count. Our finding suggest that a final postwashed total motile sperm count used for IUI may be considered predictive of the success for pregnancy