ABSTRACT
The effect of aqueous and alcohol extracts of Eleusine coracana Linn. [Poaceae] on calcium oxalate nephrolithiasis has been studied in male albino rats. Ethylene glycol feeding resulted in hyperoxaluria as well as increased renal excretion of calcium and phosphate. Supplementation with aqueous and alcohol extracts of E. coracona grains [300 mg/kg b.w., p.o.] significantly reduced the elevated urinary oxalate, showing a regulatory action on endogenous oxalate synthesis. The increased deposition of stone forming constituents in the kidneys of calculogenic rats was significantly lowered by curative and preventive treatment using aqueous and alcohol extracts. From this study, we conclude that both the prophylactic and therapeutic treatment with aqueous and alcohol extracts of grains of E. coracana had an inhibitory effect on crystal growth, with improvement of kidney function as well as cytoprotective effect