ABSTRACT
The aim of the present work was to study the effect of the crude extract of Curcuma zedoaria on peripheral blood cells and tumor progression in C57Bl/6J mice injected with B16F10 murine melanoma cells. The intraperitoneal therapy showed a significant increase in total white and red blood cell counts, a decrease in peritoneal cell number and tumor volume reduction, whereas the oral administration revealed a noteworthy augmentation only in total leukocyte count. These results contribute to evaluate the importance of alternative treatments that employ phytotherapic compounds against tumor progression and its possible immunomodulation.
Subject(s)
Animals , Curcuma , Immunologic Factors , Melanoma/chemically induced , Mice , PhytotherapyABSTRACT
Resistance to MHV3 infection was investigated in genetically homogeneous inbred (A/J, BALB/c) and genetically selected (High, Low) mouse lines. The A/J and L lines are resistant and the BALB/c and H mice are susceptible. The genetic analysis was performed on the F1 hybrids, as well as on the genetically heterogeneous F2 populations and backcrosses bred from HxL and A/JxBALB/c lines. The mortality rates of the F1 hybrids showed codominance of susceptibility and resistance characters. The results indicate that the same MHV3 susceptibility genes are present in isogenic and selected lines and corroborate previous results showing that at least two major genes are involved in the control of this response
Subject(s)
Animals , Male , Female , Coronavirus Infections/immunology , Hepatitis, Viral, Animal/immunology , Murine hepatitis virus , Crosses, Genetic , Coronavirus Infections/genetics , Coronavirus Infections/mortality , Disease Susceptibility/genetics , Hepatitis, Viral, Animal/genetics , Hepatitis, Viral, Animal/mortality , Immunity, Innate/genetics , Mice , Mice, Inbred A , Mice, Inbred BALB CABSTRACT
1. We evaluated the ability of human colostrum adhering cells to phagocytize sheep red blood cells (E) incubated with rabbit anti-E IgG antibody (A) and zymosan particles incubated with fresh human serum or with the aqueous phase of colestrum. 2. The cells were found to have considerably intense phagocytuc ability, i.e., 96,8% phagocytized EA parcicles, 83.2% phagocytized zymosan particles opsonized with fresh human serum, and 73.3% phagocytized zymosan particles opsonized with the aqueous phase of colostrum. Thus, the aqueous phase of colostrum can opsonize zymosan particles, an activity attributed to the complement system. 3. Total hemolytic complement (V+CH50) and the C3 component in a pool of normal human serum were two-fold higher than in a pool of the aqueous phase of colostum. 4. These results indicate the existence of Fcgama and C3 receptors on the membrane of human colostum macrophages and suggest that these cells may be biologically active