ABSTRACT
OBJECTIVE: To assess if there are changes in brain hemodynamics evaluated by means of transcranial dopplers flow velocity, pulsatile index and cerebral perfusion pressure, between cocaine chronic abusers and healthy volunteers. METHOD: Prospective, case and control, observational study. Sex, age, user history, vital signs and transcranial doppler findings.Statistical analysis was performed by means of normality test, Wilcoxons test for non parametric samples and T Student test. RESULTS: Fifty-three abusers and 35 healthy volunteers were studied. Statistical differences were found for a diminish in age(p=0.008) and cerebral perfusion pressure in all cerebral arteries (pSubject(s)
Cocaine/pharmacology
, Brain/blood supply
, Hemodynamics/drug effects
, Dopamine Uptake Inhibitors/pharmacology
, Cocaine-Related Disorders/physiopathology
, Adolescent
, Adult
, Young Adult
, Chronic Disease
, Prospective Studies
, Case-Control Studies
, Female
, Humans
, Male
, Middle Aged