ABSTRACT
Objective Toexploretheclinicalvalueofiterativedecompositionofwaterandfatwithechoasymmetryandleast-squaresestimationquantitationsequence(IDEAL-IQ)foraccurateandquantitativeevaluationofvertebraebodyfatfraction(FF)of lumbar.Methods Accordingtotheresultsofbonemineraldensity(BMD),60healthycheckers/patientsmatchingthestudycriteria weredividedintothenormalBMDgroup(groupA,n=17),thelowBMDgroup(groupB,n=18)andtheosteoporosis(OP)group (OP,groupC,n=25).Theageofthreegroupswasanalyzed.T1WI,T2WI,andIDEAL-IQsequenceswerescannedwithsagittallumbar.Rectangular ROIwereoutlinedonFatFracmaps,FFsweremeasuredthreetimesonvertebraebodyoflumbar1(L1),L2,L3,L4,L5,andtheFF ofeachlumbarwasrespectivelyaveragedtoanalyzethedifferencewithinandbetweengroups.Results Theageamongthethree groups(F=13.414,P=0.000)werestatisticallysignificantdifference.Inbothcomparisons,theagewassignificantdifferencebetweengroupA andB,aswellasbetweengroupAandC,butnotbetweengroupBandC.TheFFofL1-L5withineachgroupwerenotstatistically significantdifference(F=0.680,0.863,0.539,P=0.608,0.490,0.707),whilealldifferencesbetweeneachgroupwithFFofL1-L5 werestatisticalsignificance(F=12.758,9.646,5.195,8.048,8.849,P=0.000,0.000,0.008,0.001,0.000).Comparisonbetweenthe groups,theFFofL3andL5inthegroupAandBwerenotstatisticallydifferent,aswellastheL2,L3,L4inthegroupBandC, whiletheothersbetweentwogroupswerestatisticallysignificantdifference.Conclusion Astheageincreases,BMDgraduallydecreases,whilethe FFofL1-L5graduallyincreases.ItisofaccuratelyevaluatelumbarvertebraeFFbyIDEAL-IQ,whichmayhelppredictOP.
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PurposeTo investigate the relationship between left atrial volume index (LAVI) and severity of coronary lesions in patients with stable angina pectoris, so as to provide information for the evaluation of the severity of coronary artery disease (CAD). Materials and MethodsAccording to the results of coronary angiography, 279 patients with stable angina pectoris and 92 healthy people were as control group, all subjects were divided into four groups: control group (n=92), single-vessel CAD group (n=116), double-vessel CAD group (n=93) and triple-vessel group (n=70). Each group was compared in the aspects of demographic characteristics, history of illness, liver and kidney functions and parameter's difference in echocardiogram; the correlation between LAVI and Gensini score was analyzed; and the receiver operating characteristic (ROC) curve was used to identify the predictive value of LAVI in severity of coronary lesions.ResultsCompared with the control group, the double-vessel and triple-vessel CAD groups had significantly larger left atrial diameter (P<0.05). In triple-vessel CAD group, the left atrial diameter was significantly larger than that in the single-vessel CAD group (P<0.05), and the left ventricular end-diastolic diameter was significantly larger than that in the control group and in the single-vessel CAD group (P<0.05), and the E/Em and LVMI were significantly higher than those in other groups (P<0.05). The LAVI was higher in patients with CAD compared with those in the control group and the LAVI in the triple-vessel CAD group was significantly higher than that in single-vessel CAD group and double-vessel CAD group (P<0.05); the LAVI was correlated positively with Gensini score (r=0.499,P<0.01). LAVI had certain value in predicting triple-vessel CAD (AUC=0.782,P<0.01). The results of multi-factor Logistic regression analysis showed that male patients with hypertension, mitral reflux, and multi-vessel CAD were more likely to had high LAVI.Conclusion The worsening LV diastolic function is associated with the increasing severity of coronary artery lesions, and LAVI may have predictive value for severity of CAD.
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Objective To explore the application of optical coherence tomography in vascular tissue engineering culture by dynamic monitoring its changes.Methods Human umbilical artery smooth muscle cells were isolated and culture by tissue block method.After passage culture and cell surface markers evaluation, smooth muscle cells were seeded onto polyglycolic acid scaffold and placed into the bioreactor based on Luo-Ye pump with pulsatile stress for three-dimensional culture.At 1、4、 7 、10、14、17、21 days in culture, the image data was obtained by optical coherence tomography technology.The ability of imaging TEBV via OCT was analyzed combined with histopathological observation.Results As the incubation time extended,OCT clearly showed PGA gradual degradation, decreased composite scaffold thickness and the wall structure from loose to tight.At 21 days in culture, the vessel mimics had smooth surface with extracellular matrix evenly distributed and achieved complete reconstruction in the PGA scaffold.Combining with histopathological staining, the blood vessel mimics were similar to natural blood vessels.OCT measured TEBV thickness compared with histopathological measurement had good correlation (r =0.922,P ＜ 0.05).Conclusion Optical coherence tomography could clearly image microstructures of tissue engineered blood vessels cultured in three-dimensional culture system based on Luo-Ye pump, delineate the reconstruction of TEBV-like tissue in the bioreactor and provide as a dynamic and convenient monitoring tool in vascular tissue engineering.
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Objective To explore the value of left atrium volume index (LAVI) in the diagnosis of heart failure with preserved ejection fraction (HFPEF). Methods Seventy-seven patients with HFPEF and 33 patients without HFPEF who had been treated from May 2012 to September 2013 in Guangdong General Hospital were en-rolled. The clinical data and a series of ultrasound parameters were collected and analysed. The relationship between LAVI, LAV, and other indexes of diastolic function was determined by Pearson correlation analysis. The value of LAVI and LAV for diagnosing HFPEF was compared by the ROC curve. Results LAVI and LAV of were signifi-cantly greater in HFPEF group than in non-HFPEF group. LAV and LAVI were significantly associated wtih HEPEF. The area under the ROC curve (AUC) of LAVI increased significantly as compared with the AUC of LAV (0.832 vs. 0.799, P<0.05). With a cut-off value of 30 mL/m2, the specificity and sensitivity for diagnosing HEPEF were 64.9%and 84.8%, respectively. Conclusions LAVI may be valuable in the diagnosis of HFPEF.