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Objective To investigate the clinical effect of anterior cervical decompression and titanium mesh with locking plate fixation in the treatment of cervical spondylosis.Methods From January 2015 to January 2016,58 patients with cervical spondylosis in Zhoushan Hospital of Traditional Chinese Medicine were selected and randomly divided into two groups,with 29 cases in each group.The control group received the anterior cervical decompression and autogenous iliac bone graft with locking plate fixation.The observation group received anterior cervical decompression and titanium mesh with locking plate fixation.The operation time,bleeding volume and postoperative complications were recorded in the two groups.The patients were followed up for 1 year after operation,the recovery of neurological function was evaluated by,JOA standard,and the bone graft fusion rate was compared between the two groups.Results The operation time,blood loss of the observation group were (80.12 ±5.13)min,(61.45 ± 3.75) mL,respectively,which were significantly less than those of the control group,the differences were statistically significant (t =2.956,2.254,all P ＜ 0.05).The incidence rate of postoperative complications in the observation group was 6.90％,which was significantly lower than 24.14％ in the control group,the difference was statistically significant(x2 =8.540,P ＜ 0.05).The postoperative JOA score of the observation group was (88.95 ± 10.41)points,which was significantly higher than (82.11 ± 7.03)points of the control group,the difference was statistically significant (t =2.192,P ＜0.05).After 1 year follow-up,the fusion rate of the observation group was 96.55％ (28/29),which of the control group was 93.10％ (27/29),the difference was not statistically significant (x2 =2.862,P =0.090).Conclusion Anterior cervical decompression and titanium mesh with locking plate fixation in the treatment of cervical spine injury has good curative effect,and has the advantages of small trauna and high bone fusion rate.
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Objective To study the value of zoledronic acid combined with psychological intervention in osteoporotic vertebral compression fractures in percutaneous balloon kyphoplasty (PKP). Methods 72 patients with osteoporotic vertebral fractures underwent PKP operation from August 2013 to August 2015 were randomly divided into observation group and control group,with 36 cases,in each group. The patients in the control group were given salmon calcitonin after operation. The patients in the observation group were given zoledronic acid after operation. Both patients were given psychological care. The total effective rate of clinical treatment and the incidence of secondary osteoporotic vertebral compression fractures,Visual analogue pain scale before and after treatment (VAS), Oswestry dysfunction index questionnaire (ODI) score, bone mineral density T value changes were compared between the two groups. Results The total effective rate was 94.44% in the observation group and 77.78% in the control group (P<0.05). The recurrence fracture rate was significantly lower than that of the control group (P<0.05). After treatment, the scores of VAS and ODI in the observation group were significantly lower than those in the control group (P<0.05). The T value of bone mineral density was significantly higher than that of the control group (P<0.05). Conclusion Zoledronic acid combined with psychological intervention can effectively improve the effective rate of PKP after osteoporotic vertebral compression fractures, increase bone density and reduce the incidence of fracture, which is worthy of clinical application.
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The main problems existing in the internal control of public medical institutions are pointed out and the suggestions about how to establish and perfect it were proposed, so as to assume its due role, according to its concept and benefits, combined with the analysis of present situation of internal control in public medical institutions in Putuo District.
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Objective To investigate the gene mutation of epithelial growth factor receptor(EGFR) and the expressions of hu‐man epiderma1 growth factor receptor 2(HER‐2) and vascular endothelial growth factor(VEGF) in lung adenocarcinoma and their relationships with the clinical pathological factors .Methods ARMS‐PCR method was used to detect the gene mutation of EGFR in 49 lung adenocarcinoma specimens and 10 normal tissue specimens .Immunohistochemical method was also used to detect the ex‐pressions of the HER‐2 and VEGF in them .Results (1) The mutation rates of EGFR and the positive rates of HER‐2 and VEGF in lung adenocarcinoma were significantly higher than those in the normal tissues(P0 .05) .The HER‐2 and VEGF protein expressions in lung adenocarcinoma were correlated with differential ,the size of tumor ,TNM stages ,lymph nodes metastasis and pleural invasion(P0 .05) .(3) The expressions of HER‐2 and VEGF protein in the lung adenocarcinoma were positively correlated with each other(P<0 .01) .Conclusion EGFR mutation is closely related to the occurrence of lung ade‐nocarcinoma ,its high expressions in the women ,non smoking people have important clinical significance .HER‐2 and VEGF could promote the lung adenocarcinoma′s occurrence ,development and transfer .They could be used to evaluate the patients′prognosis ,and provide new molecular targeted therapy .
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<p><b>OBJECTIVE</b>To study the chemical constituents of Hemsleya chensnsis.</p><p><b>METHOD</b>Various chromatographic techniques were used to separate and purify the constituents. The spectral data (MS, NMR) were obtained for structure elucidation.</p><p><b>RESULT</b>Eight known triterpenoid saponins were isolated from the root of H. chensnsis. Their structures were elucidated as dihydrocucurbitacin B (1), 25-O-acetyl-dihydrocucurbitacin F (2), cucurbitacin F (3), 3-O-(6'-ethyl ester) -beta-D-glucuropyranosyl oleanolic acid-28-O-alpha-L-arabinopyranoside (4), oleanolic acid-3-(6'-methyl ester) -beta-D-glucuropyranosyl (1-3) -alpha-L-arabinopyranoside (5), oleanolic acid-28-O-beta-D-glucopyranosyl-(1-6) -beta-D-glucopyranoside (6), 3-O-(6'-methyl ester) -beta-D-glucuropyranosyl oleanolic acid-28-O-beta-D-glucopyranosyl-(1-6) -beta-D-glucopyranoside (7), 3-O-(6'-methyl ester) -beta-D-glucuropyranosyl (1-2) -beta-D-glucopyranoside-oleanolic acid-28-O-beta-D-glucopyranoside (8).</p><p><b>CONCLUSION</b>All compounds except for 2 were isolated from H. chensnsis for the first time.</p>