ABSTRACT
<p><b>OBJECTIVE</b>The primary aim of the study was to compare two nutritional status evaluation tools: the Patient-Generated Subjective Global Assessment (PG-SGA) and Nutritional Risk Screening (NRS-2002). Using the European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire 30 (EORTC QLQ-C30), the second aim was to provide constructive advice regarding the quality of life of patients with malignancy.</p><p><b>METHODS</b>This study enrolled 312 oncology patients and assessed their nutritional status and quality of life using the PG-SGA, NRS-2002, and EORTC QLQ-C30.</p><p><b>RESULTS</b>The data indicate that 6% of the cancer patients were well nourished. The SGA-A had a higher sensitivity (93.73%) but a poorer specificity (2.30%) than the NRS-2002 (69.30% and 25.00%, respectively) after comparison with albumin. There was a low negative correlation and a high similarity between the PG-SGA and NRS-2002 for evaluating nutritional status, and there was a significant difference in the median PG-SGA scores for each of the SGA classifications (P < 0.001). The SGA-C group showed the highest PG-SGA scores and lowest body mass index. The majority of the target population received 2 points for each item in our 11-item questionnaire from the EORTC QLQ-C30.</p><p><b>CONCLUSION</b>The data indicate that the PG-SGA is more useful and suitable for evaluating nutritional status than the NRS-2002. Additionally, early nutrition monitoring can prevent malnutrition and improve the quality of life of cancer patients.</p>
ABSTRACT
Objective: To investigate the effects of liposome nanoparticles of hydrazinocurcumin (HC-NPs) on cells proliferation, apoptosis, invasion, and migration in human breast cancer MDA-MB-231 cells. Methods: Liposome HC-NPs were prepared by film-sonication method and then were used to treat human breast cancer MDA-MB-231 cells. The treated cell survival was analyzed by MTT; Morphological changes were detected by Liu staining; The cell cycle and apoptosis were investigated by FCM assay; Then invasion and migration of the cells were analyzed by Transwell. Moreover, the expression of proteins correlated to cell cycle arrest, apoptosis, invasion, and migration were detected by Western blotting. Results: The cell proliferation was inhibited by HC-NPs, the cells became round in shape, and the cells were arrested in G 2/M phase, the ratio of apoptosis was increased (P<0.01), the cells invasion and migration were restrained. The expression of p-STAT3, CyclinD1, Survivin, Bcl-2, and MMP-9 were down-regulated, while the expression of Bax was up-regulated. Conclusion: The effects of HC-NPs on the suppression of cell proliferation, invasion, and migration, and induction of cells apoptosis may be related to the inhibition of STAT3 activation.