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<p><b>OBJECTIVE</b>To study the relationship between ABO blood groups and hypertensive intracerebral hemorrhage (HICH).</p><p><b>METHODS</b>The clinical data of 425 patients with HICH admitted to Nanfang Hospital were collected to analyze the relationship between the ABO blood groups and the occurrence of HICH, with normal Han Chinese subjects serving as the controls.</p><p><b>RESULTS</b>Compared to the officially documented distribution of ABO groups in Chinese population (O 34.11%, B 28.98%, A 28.29%, AB 8.69%) and in Guangzhou residents (O 46.00%, B 25.00%, A 23.00%, AB 6.00%), a significant difference was noted in the blood group distribution in this cohort (O 45.10%, A 26.00%, B 24.00%, AB 4.90%). O blood type individuals with HICH showed a higher morbidity than others. Th ABO blood type distribution in this cohort showed no significant difference from that in the control group (P>0.05), but differed significantly from the Chinese norm (P<0.05).</p><p><b>CONCLUSION</b>The ABO blood group is a factor contributing to the occurrence of HICH. O blood type is related to cerebral hemorrhage, and may serve as a risk factor for HICH.</p>
Subject(s)
Adolescent , Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Young Adult , ABO Blood-Group System , Genetics , Case-Control Studies , Intracranial Hemorrhage, Hypertensive , Epidemiology , Genetics , Risk FactorsABSTRACT
Objective To investigate the relationship between CT scanning results and clinical prognosis in patients with hypertensive intracerebral hemorrhage(HICH) and to provide clinical evidence for recurrence, stroke prevention, and the management of high risk HICH people. Methods The data of 425 patients (male 269, female 156) with HICH admitted to our hospital from January, 2000 to December, 2004 were collected and the relationships among bleeding locations, volumes of bleeding, age, gender and their prognosis were examined. These data were analyzed with SPSS 10.0 software. Results In all patients with HICH, supratentoriai intracerebral hemorrhage (SICH, 87.53%) was mainly showed with an average volume of bleeding of (30.042±27.905) ml and 39 death (10.5%);infratentorial intracerebral haemorrhage (IICH, 8.94%) appeared with an average volume of bleeding of (7.838±5.761) ml and 2 death (5.3%). As to bleeding location, the basal ganglia ranked first (65.65%), the lobe of brain accounted for 20.71% and following ones were the brain stem (6.12%), the ventrieular system (3.29%), the cerebellum (2.82%), the corona radiate (0.71%), the corpus eallosum (0.47%) and multi-site hemorrhage (0.24%). Bleeding locations significantly differed among different age groups (X<'2>=22.080, P=0.001). Conclusions Mortality of HICH is higher in patients with SICH than that in patients with IICH. Volume of bleeding is one of the most important risk factors and 40 mL is the maximum bleeding. The more volume of bleeding is;the higher mortality is. Morbility and age are positively correlative, while younger group have significantly higher morbility of IICH than elder group because their circuitous and dilated vertebral artery may be a kind of protective mechanism which can reduce the development of HICH to some extent. Early CT scanning can note bleeding location and volume of bleeding, and then help to determine proper treatment and predict clinical prognosis.
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Objective To study the relationships between hypertensive intracerebral hemorrhage (HICH) and family history of hypertensive disease, gender, age and disease course in Guangzhou. Methods The clinical profiles of 425 (269 male and 156 female) patients with HICH admitted to Nanfang Hospital, Guangzhou from 2000 to 2004 were collected. The relationships between disease incidences in different family histories of hypertensive disease, genders, ages, courses of disease and blood pressure were analyzed. Results In all 425 cases with HICH, the ratio of male to female of people with family history of hypertensive disease was significantly higher than that without in male.There were no obvious differences between with and without family history in female. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were higher in the male than in the female in young group. In middle-aged group and elder group, there were no significant differences in SBP and DBP between the male and the female. The distributions of SBP and DBP were all acute stage＞ subacute stage＞ convalescence stage. Conclusions Hypertensive disease should be supplied with different strategies of prevention and cure in accordance with different ages, genders and courses of disease, which can decrease the incidence of hypertensive intracerebral hemorrhage maximally.
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<p><b>OBJECTIVE</b>To study the chemical constituents of Dregea sinensis var. corrugata.</p><p><b>METHOD</b>The chemical constituents were isolated by various column chromatographic techniques. Structures were elucidated on the basis of NMR data.</p><p><b>RESULT</b>Eight compounds were isolated and their structures were elucidated as syringaresinol (1), syringaresinol-O-3-D-glycopyranoside (2), 3, 4'-dimethoxyl-4, 9, 9'-trihydroxyl-benzofuranneolignan-7'-ene (3), 3, 4'-di- methoxyl-4, 9-dihydroxyl-9'-hydroethyl-benzofuranneolignan-7'-ene (4), conifer-aldehyde (5), sinapic aldehyde (6), 3-hydoxy-1-(4-hydroxy-3-methoxy-phenyl)-propan-1-one (7), 3-hydroxy-1-(3-methoxy-4-hydroxyphenyl)-propan-1-one (8).</p><p><b>CONCLUSION</b>Compounds 1-8 were isolated from Dregea sinensis var. corrugata for the first time.</p>
Subject(s)
Apocynaceae , Chemistry , Drugs, Chinese Herbal , Chemistry , Plants, Medicinal , Chemistry , Propane , ChemistryABSTRACT
<p><b>OBJECTIVE</b>To study the mechanism of Ca(2+) on the apoptosis induced by hyperthermia in neonate rat hippocampal neurons to provide the applicative evidence of dantrolene for preventing brain injuries.</p><p><b>METHODS</b>Dantrolene, Ca(2+) specific blocking agent, was used in the hyperthermia-induced apoptosis of primary hippocampal neurons in vitro to observe its effect on the apoptosis, fluorescent intensity, and dynamic change of Ca(2+) by flowcytometry and laser confocal microscopy.</p><p><b>RESULTS</b>The rate of apoptosis was decreased significantly after hyperthermia treatment by dantrolene sodium. The intracellular Ca(2+) fluorescent intensity in 42 degrees C treatment group (107.35 +/- 6.0) was significantly lower than that in control group (159.12 +/- 33.8). The concentration of Ca(2+) began to decrease 20 approximately 25 s after adding dantrolene sodium, and reached the lowest level about 50 s later, and then kept lower than the basal level.</p><p><b>CONCLUSION</b>Dantrolene sodium has an important protective effect on hippocampal neurons apoptosis induced by hyperthermia and may have some applicative value of preventing heat-induced brain injury.</p>