ABSTRACT
Objective To study the protective effect of breastfeeding on the occurrence of type 2 diabetes mellitus(T2DM) in women with gestational diabetes mellitus(GDM).Methods A total of 660 GDM women were enrolled in this prospective co-hort study.Blood glucose levels were detected 6 to 9 weeks after delivery(baseline)and then on a year basis for 2 years.The re-lated data of T2DM were collected.Stata 12.0 and SPSS 20.0 were used for data analysis.Results In total,615 women completed the follow-up tests.Seventy-eight(12.7%)were diagnosed as having T2DM,and the incidence rate was 5.919/(1000 person·month) .Twenty-four in formula feeding group were diagnosed as having T2DM,and the incidence rate was 8.153/(1000 person· month).Forty-two in mixed feeding group were diagnosed with T2DM,and the incidence rate was 5.657/(1000 person · month).Twelve in breastfeeding group were diagnosed as having T2DM,and the incidence rate was 4.091/(1000 person· month).Weibull regression model analysis showed that after adjustment of confounding factors,the hazard ratios in mixed feed-ing group and breastfeeding group versus formula feeding group were 0.52(95% CI:0.28~0.89)and 0.43(95% CI:0.23~0.82),respectively(P=0.023).Conclusion Breastfeeding can effectively reduce the risk for T2DM in GDM women.It is effec-tive to control the occurrence of T2DM by strengthening the follow-up of GDM women and postpartum weight control.
ABSTRACT
Objective: To study influencing factors for aspirin resistance in women with ischemic stroke.Methods: A total of 150 women with ischemic stroke, who visited to our hospital from Jun 2013 to Jun 2015, were selected.According to presence of aspirin resistance, they were divided into aspirin resistance group (n=61) and aspirin sensitive group (n=89).All patients received aspirin enteric-coated tablets on morning, then arachidonic acid pathway platelet aggregation inhibition rate and glycosylated hemoglobin A1c (HbA1c) level were measured in two groups on 10 h after administration.According to HbA1c level, patients were divided into normal blood glucose group (n=83) and elevated blood glucose group (n=67), then aspirin resistance rate was compared between two groups.Logistic regression analysis was used to analyze influencing factors for aspirin resistance.Results: Compared with aspirin sensitive group, there was significant rise in body weight[(63.5±7.9) kg vs.(66.9±10.2) kg]in aspirin resistance group, P=0.041.Compared with normal blood glucose group, there was very significant rise in aspirin resistance rate (14.46% vs.73.13%) in elevated blood glucose group, P=0.008.Multi-factor Logistic regression analysis indicated that body mass index (BMI) and blood glucose level were independent risk factors for aspirin resistance (OR=4.012, 3.012, P=0.016, 0.018).Conclusion: Incidence rate of aspirin resistance is high in women with ischemic stroke.Blood glucose control and body weight status may affect incidence of aspirin resistance.
ABSTRACT
<p><b>BACKGROUND</b>Nasopharyngeal carcinoma (NPC) is a squamous-cell carcinoma especially prevailing among the natives of southern China. The regimen of concurrent chemoradiotherapy (CCRT) that include platinum and 5-fluorouracil (5-FU) is considered to be the standard treatment for NPC. However, its clinical use is limited by its toxicity. Our purpose was to evaluate the efficacy and safety of the regimen of CCRT with taxanes and platinum versus the regimen of CCRT with 5-FU and platinum in NPC treatment.</p><p><b>METHODS</b>Medline, the Cochrane library, and the Chinese medical literature database were searched for eligible studies. Meta-analysis was performed using Review Manager (Version 5.2).</p><p><b>RESULTS</b>Six random controlled trials (RCTs) including 514 patients met our criteria. Meta-analysis showed that the regimen of CCRT with taxanes and platinum had an improved significant difference in complete remission (CR) and less incidence rate in adverse reactions such as gastrointestinal impairment grades III-IV, liver and kidney impairment grades I-II, and radiodermatitis grades III-IV versus the conventional regimen of CCRT with 5-FU and platinum, while the longterm effectiveness rate of overall survival, locoregional failure-free survival, or distant metastasis failure-free survival between the two groups was therapeutic equivalence.</p><p><b>CONCLUSIONS</b>The regimen of CCRT with taxanes and platinum in NPC therapy may be more efficient and safe compared to the conventional modality of 5-FU and platinum in CCRT. However, we need more high-quality studies of multi-center and randomized double-blind clinical trials to further compare, analyze, and confirm the findings.</p>