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Objective:To observe the glycemic profiles and emotion management in diabetic patients after the outbreak of novel coronavirus disease 2019(COVID-19).Methods:A questionnaire survey was used to observe the blood glucose levels and metabolic indexes before and after the outbreak of COVID-19, and to detect emotion ratings after the outbreak of COVID-19. The aim of the study is to present the effects of the COVID-19 on glycemic and emotional management in diabetic patients.Results:A total of 136 patients were included in this survey. The average age of the patients was 62.5 years old, and the average duration of diabetes was 10.1 years. Glycemic profiles(fasting blood glucose, 2 h postprandial blood glucose, HbA 1C), lipid profiles(triglycerides, low-density lipoprotein cholesterol), and body weight were not significantly different before and after the outbreak of COVID-19( P>0.05). According to emotional scales(scores of anxiety, depression, and sleep-related scales), 76.5% diabetic patients did not develop anxiety symptoms, 61.0%~69.9% diabetic patients did not have depressive symptoms and 52.0% diabetic patients did not have sleep disorder. 19.9% diabetic patients had mild anxiety symptoms, 25.7%~30.9% diabetic patients presented mild depression symptoms and 28.3% diabetic patients had mild sleep disorders. 2.9% diabetic patients had moderate anxiety, 2.2%~8.1% diabetic patients had moderate depression and 14.2% diabetic patients had moderate sleep disorder. Only a very small part of patients presented severe emotional symptoms including 0.7% patients with anxiety symptoms(GAD-7 15 points and above), 2.2% patients with depressive symptoms(PHQ9 and PHQ15 15 points and above)and 5.6% patients with sleep symptoms(PSQI 15 points and above). Compared with asymptomatic patients, neither patients with mild and moderate/severe depression and sleep disorder showed significant difference in HbA 1C, nor did patients with moderate/ severe anxiety symptoms. However, patients with mild anxiety symptoms showed significant lower HbA 1C than asymptomatic patients. Conclusion:After the outbreak of COVID-19, there was an increasing trend in blood glucose, but there was no statistical difference. Body weight, lipids profiles were not different in diabetic patients, either. Most of diabetic patients had mild symptoms of anxiety, depression and sleep disorders. Very few patients presented moderate to severe symptoms of anxiety, depression and sleep disorders.
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Objective: To investigate the effect of urantide on the levels of serum calcium, blood lipids and indexes of myocardial enzymes in the rats with atherosclerosis (As), and to clarify its mechanism of prevention and treatment of AS. Methods: A total of 180 Wistar rats were selected and randomly divided into normal control group, AS group, positive drug (simvastatin) group and urantide groups (3, 7 and 14 d group), 30 rats in each group. The rat model of AS was established by feeding on high-fat diet or intraperitoneally injecting vitamin D3 (VDs). The body weights of rats were weighed at three time points: pre-experiment, pre-administration and end of experiment. The levels of Ca", total cholesterol (T O, triglyceride (TG), low density lipoprotein (LDL), high density lipoprotein (HDL), creatine kinase (CK) and lactic dehydrogenase (LDH) in the serum of the rats in various groups were detected by automatic biochemical analyzer. Results: The body weights of the rats in normal control group were gradually decreased with the prolongation of time; compared with normal control group, the body weights of the rats in AS group at the time point of pre-administration was decreased (P < 0 . 01); compared with AS group, the body weights of the rats in different administration groups were increased (P < 0 . 05 or P< 0. 01). The levels of serum Ca2', TG, TC, LDL, CK and LDH of the rats in AS group were significantly higher than those in normal control group, and the level of HDL was decreased significantly (P < 0 . 01). Compared with AS group, the levels of serum Ca2 , TC, TG, LDL, CK and LDH of the rats in urantide group were significantly decreased (P < 0. 05 or P < 0. 01), while the HDL levels were higher (P < 0. 05 or P < 0. 01). Conclusion: Urantide can prevent and treat AS by down-regulating or up-regulating the levels of serum calcium, blood lipids and indexes of myocardial enzymes in the AS rats.
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Objective@#To compare the effect of gum elastic bougie and laryngoscope on the stress response to endotracheal intubation in critically ill patients.@*Methods@#A total of 110 cases patients admitted to intensive care unit who needed intubaton from January 2015 to December 2017 were randomly divided into 2 groups: gum elastic bougie group (gum elastic bougie was used for intubation) and Macintosh laryngoscope group(laryngoscope intubation was performed) with 55 patients in each group. The mean arterial blood (MAP) and heart rate (HR) were recorded before intubation(T0), 1 min after intubation (T1), 3 min after intubation(T2) and 5 min after intubation(T3). The concentration of norepinephrine(NE) and epinephrine(E) in the vein were measured at T0 and T2.@*Results@#The levels of MAP, HR, NE and E were increased in both groups after intubation (P<0.05). At T1, T2 and T3, the levels of MAP in gum elastic bougie group [(101.5 ± 6.4), (92.1 ± 3.3), (84.4 ± 7.7) mmHg, 1 mmHg=0.133 kPa] were significantly lower than those in Macintosh laryngoscope groupgroup [(116.2 ± 17.8), (110.4 ± 9.7), (97.5 ± 6.4) mmHg](P<0.05). The level of HR in gum elastic bougie group at T1 [(95.4 ± 7.9) times/min] was significantly reduced than that in Macintosh laryngoscope group [(112.7 ± 12.6) times/min](P<0.05). After intubation, the concentration of NE and E in gum elastic bougie group [(161.28 ± 10.45), (105.04 ± 7.31) ng/L] were reduced than those in Macintosh laryngoscope group [(189.32 ± 11.56), (128.61 ± 3.68) ng/L], there were significant differences between two groups (P<0.05).@*Conclusions@#Compared with normal laryngoscope, gum elastic bougie guided intubation is of great significance in terms of better hemodynamics and less stress response.
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Objective To investigate work stress state of nursing home staff and to analyze the influential factors affecting work stress.Methods Stratified random sampling method was adopted to investigate 180 nursing assistants by self-designed questionnaire,Work Stress Scale(WSS),Simplified Coping Style Questionnaire and internal-external locus of control scale investigation.Results Totally 174 valid questionnaires were collected.Variance analysis revealed there were significant differences of age and other factors.Stepwise multiple regression analysis showed five variables entered the equation,including workexpenence education level number of the cared ages work scheduline coping stule and explain 56.7％ of the total variable.Conclusion Nurse managers should pay attention to and improve achievement sense and mental adjustment ability of nursing assistants,to build a well-organized support system to reduce the workload.