ABSTRACT
Urothelial carcinoma associated 1 was initially discovered and confirmed that was specifically high expressed in bladder cancer.The aberrant expression of UCA1 was reported in various tumors,especially in tumors occurred in digestive system and urogenital system.Recently,more and more advances have indicated that UCA1-overexpressed in a larger number tumors to play oncongenic roles in tumor onset,progression,and metastasis.However,the molecular mechanism of UCA1 in cancer development,progression and metastasis remains to be further explored.In this review,we focus on structure and isoforms of UCA1,function and mechanism for UCA 1 tumor-promoting effect.We further discuss the potential clinical application of UCA1 as a promising diagnostic biomarker or therapeutic target for human tumors.
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association of maternal body composition and dietary intake with the risk of gestational diabetes mellitus (GDM).</p><p><b>METHODS</b>A total 154 GDM subjects and 981 controls were enrolled in a prospective cohort study in 11 hospitals from May 20, 2012 to December 31, 2013. Bioelectrical impedance analysis and dietary surveys were used to determine body composition and to evaluate the intake of nutrients in subjects at 21-24 weeks' gestation (WG). Logistic regression analysis was applied to explore the relationships of maternal body composition and dietary intake with the risk of GDM morbidity.</p><p><b>RESULTS</b>Age, pre-pregnant body weight (BW), and body mass index (BMI) were associated with increased risk of GDM. Fat mass (FM), fat mass percentage (FMP), extracellular water (ECW), BMI, BW, energy, protein, fat, and carbohydrates at 21-24 WG were associated with an increased risk of GDM. In contrast, fat free mass (FFM), muscular mass (MM), and intracellular water (ICW) were associated with a decreased risk of GDM.</p><p><b>CONCLUSION</b>Maternal body composition and dietary intake during the second trimester of pregnancy were associated with the risk of GDM morbidity.</p>