Research progress on ion channels and receptors in nodose ganglion neurons involved in blood pressure regulation / 药学学报

Hypertension is the most common cardiovascular disease. In recent years, reduced baroreceptor activity has been suggested as a main cause of hypertension. The cell body of the primary afferent nerve of the baroreceptor is located in the nodose ganglion (NG). The ion channels and receptors in the NG can affect baroreceptor sensitivity and neuronal excitability, thus regulating blood pressure. This review focuses on recent research progress on ion channels, receptors and other proteins in NG neurons that are involved in modulating the sensitivity of the baroreceptor reflex to regulate blood pressure.

Modulation of potassium channels by receptor tyrosine kinases: Recent progress / 第二军医大学学报

Receptor tyrosine kinase (RTK), a membrane receptor superfamily with intrinsic protein tyrosine kinase activity, has many members and complicated signal transduction pathways. Activation of RTKs can trigger a series of signal transduction pathways and play essential roles in modulating cell growth, proliferation, differentiation and metabolism through influencing gene transcription and expression. Activation of RTK can also rapidly modulate some cellular functions including the modulation of ion channels. Potassium channels play a critical role in stabilization of membrane potential and regulation of cellular excitability. This review highlights the rapid modulation of potassium channels by RTKs and reviews the recent progress in related research.