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Objective@#To monitor and analyze the epidemiological characteristics of influenza in schools and understand the disease burden of students, and to provide a scientific reference for instructing the prevention of influenza in schools.@*Methods@#A school influenza surveillance sentinel to conduct influenza like case (ILI) surveillance and outbreak surveillance. Through network, we understood the burden of flu disease among students. Descriptive epidemiology was used to analyze influenza like case surveillance and questionnaire survey data.@*Results@#Surveillance confirmed that from the 42th week of 2019 to the 1st week of 2020, the cumulative reported ILI of 3 school influenza surveillance sites in Jinan accounted for 7.91% (ILI%) of the total number of surveillance personnel during the same period, with the highest ILI% (24.19%) of kindergarten children, ILI% gradually decreased with the increase of grade, and teachers were the lowest. The reporting of ILI was concentrated in the 49th to 52nd week of 2019, during which the reported influenza like cases accounted for 84.81% of the total number of ILI reported during the surveillance period. Two influenza outbreaks were monitored. The pathogens were H3N2 and B (Victoria). The epidemics mainly occurred in the lower grades of elementary school. A survey of 2 297 students found that 577 people had fever and respiratory symptoms since October 2019. Among them, 85.26% of them went to the hospital, 32.75% of those who used anti influenza drugs such as oseltamivir, and 64.81% of those who used antibiotics. 42.63% received infusion therapy, 3.99% were hospitalized, and the average cost of inpatients was 6 686 yuan. The sick students were absent from school for an average of 3.77 days, and the parents of the sick children missed work for an average of 4.26 days.@*Conclusion@#Surveillance of influenza like cases in schools is an important way to proactively discover influenza epidemic trends and outbreaks, and to accurately grasp the characteristics of influenza epidemics in schools. The key populations affected by influenza are kindergarten children and lower grades of primary school students. Suffering from influenza has caused a heavy disease burden on students and children in kindergartens, and is also an important factor that causes student absenteeism and parents to miss work.
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This study compared and analyzed the differences, similarities and advantages of midwifery courses for undergraduate education between North Sichuan Medical College and Fooyin University. Obvious differences have been found in educational system, core curriculum and practical teaching of these two universities. Fooyin University has more theoretical and practical hours of the two professional core courses of Midwifery and Midwife Technique than those of North Sichuan Medical College. However, the number of courses set and the internship hours in clinical departments related to midwifery are less than those in North Sichuan Medical College. It is hoped that through the analysis and summary, it will provide reference for further training of midwifery professionals in our country.
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Objective To establish a HPLC method for the assay of cyproheptadine hydrochloride and the related sub-stances.Methods TheHPLCwasperformedonanAgilentEclipseXDB-C18column(4.6mm×250mm,5μm)atthetemper-ature of 25 ℃ with the mobile phase of acetonitrile-buffer Solution ( Dissolve 2 .16 g of sodium octane-1-sulfonate with about 500 ml of water and mix well .Add 10 .0 ml of glacial acetic acid and 5 .0 ml of triethylamine ,and dilute with water to 1 000 ml ,mix well and adjust to pH 7 .0 with triethylamine) (85∶15 ,V/V ) .The flow rate was 1 .0 ml/min and detection wavelength was 286 nm .The injection volume was 10μl .Results The calibration curves of cyproheptadine hydrochloride ,im-purity A ,B and C showed good linear response in the range from 0 .056 2 to 5 .620 μg/ml (r= 0 .999 8) ,0 .052 4 to 5 .240 μg/ml(r=1 .000 0) ,0 .050 3 to 5 .032 μg/ml (r=0 .999 9) and 0 .053 2 to 5 .316 μg/ml(r=0 .999 8) respectively .The LOQs for cyproheptadine hydrochloride ,impurity A ,B and C were within 0 .049-0 .054 μg/ml ,LODs were within 0 .019-0 .022 μg/ml with recovery between 98%-100% .RSD of repeatability was 5 .5% (n=6) .Conclusion This method gave an accurate and reliable results .It can be used for quality control of cyproheptadine hydrochloride .
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The emergent and severe diseases always shows the characteristics of acute course, severe condition, rapid changes, and many complications. The common treatments based on syndrome differentiation usually lacked dynamics and promptness. The treatment of emergent and severe diseases emphasized the importance of early interventions, which can reverse the acute trend of the diseases and improve the outcomes. This article discuessed in five parts, including the meaning and significance of trend identification, the physiological and pathological trend of the human body, the influence factors of diseases' trend, how to carry out a trend identification and intervention strategies of trend identification. It elaborated the theory about the trend identification in the emergent and severe diseases.
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Objective To establish an HPLC method for assay determination of fluoxetine hydrochloride .Methods Agi‐lent Eclipse XDB‐C8 (4 .6 mm × 250 mm ,5μm) was used ,mobile phase was tetrahydrofuran‐methanol‐triethylamine buffer (to 10 ml of triethylamine in a 1 000 ml flask ,added 980 ml of water ,pH was adjust to 6.0 by phosphoric acid) (30:10:60) ,flow rate was 1 .0 ml/min ,detection wavelength was 227 nm ,injection volume was 10 μl ,column temperature was 25 ℃ .Results Linearity range was 55 .17‐165 .51 μg/ml (r= 0 .999 9) ,minimum detection limit was 0 .15 μg/ml ,accuracy was between 99.9%‐100 .0% ,repeatability RSD was 0 .1% (n=6) .Conclusion The method was accurate and reliable ,which could be ap‐plied for quality control of fluoxetine hydrochloride .
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Objective To evaluate the value of tumor necrosis factor -α( TNF-α) ,leptin ( LEP) ,interleu-kin-6 (IL-6) and carcinoma embryonic antigen (CEA) in both serum and pleural effusion in differential diagnosis of tuberculosis and malignant tumor .Methods Detection were performed on tuberculosis and malignant tumor patients,comparation was conducted on the level and positive ratio of TNF -α,LEP,IL -6 and CEA in different groups.Results The levels of TNF-α,LEP,CEA in serum decreased significantly compared with malignant tumor patients[(34.45 ±17.11)μg/L vs (70.26 ±19.31)μg/L,(490.71 ±197.58)μg/L vs (2 013.62 ±596.22)μg/L, (226.81 ±87.09)μg/L vs (5 329.62 ±1 523.58)μg/L;t=5.221,9.673,12.078;P=0.012,0.031,0.000],but IL-6 was not [(159.73 ±30.33)μg/L vs (22.31 ±3.20)μg/L;t=-16.114;P=0.001];The level of TNF-α, LEP,CEA in pleural effusion was decreased significantly compared with malignant tumor patients [( 20.31 ± 5.62)μg/L vs (42.06 ±14.07)μg/L,(702.46 ±375.01)μg/L vs (4 532.27 ±2 307.83)μg/L,(112.25 ± 48.72)μg/L vs (4 190.84 ±1 534.29)μg/L;t=5.017,12.096,12.236;P=0.022,0.016,0.033],but IL-6 was not [(92.15 ±32.64)μg/L vs (10.29 ±3.91)μg/L,t=-11.583;P=0.031].The positive ratio of TNF -α, LEP,CEA in serum was decreased significantly compared with malignant tumor patients (17.8% vs 72.2%,20.0%vs 91.7%,0.0% vs 100.0%;χ2 =24.341,41.145,81.000;P =0.000,0.000,0.000),but IL -6 was not (100.0%vs 0.0%,χ2 =81.000;P=0.000);The positive ratio of TNF -α,LEP,CEA in pleural effusion was decreased significantly compared with malignant tumor patients (28.9% vs 75.0%,4.4% vs 100.0%,0.0% vs 97.2%;χ2 =17.012,73.326,77.038;P=0.000,0.000,0.000),but IL -6 was not(97.8% vs 0.0%,χ2 =77.059;P=0.000).Conclusion The level and positive ratio of malignant tumor patients are higher than tuberculo-sis patients,but IL-6 is not,these indicators are helpful in diagnosing tuberculosis and malignant tumor .
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Objective To learn about the status of stress to the life affairs of Tibetan nursing students on 9+3 free Education Programs,and corresponding intervention of mental health problem were put forward.Methods 120 Tibetan nursing students through random sampling were evaluated with Adolescent Self-Rating Life Events Check List (ASLEC).Results The average scores of items such as study pressure,interpersonal relationship and health adaptation were above the median level.The scores of interpersonal relationship,punishment and loss in the 1st grade were significantly higher than those in the 2nd grade and 3rd grade.The score of study pressure in the 2nd grade was higher compared with that in the other grades.In comparison with the other grades,the score of health adaptation in the 3rd grade was higher,and there was significant difference.Conclusions Influence of stress to the life affairs on psyche of Tibetan nursing students in different grades is different.Tibetan nursing students should be given directed intervention of mental health problem according to their risk factors of stress to the life affairs.
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Objective To explore the status of stress to the life affairs between Tibetan nursing students on 9+3 free education programs and mainland nursing students.According to the diversity of them,corresponding nursing interventions of mental health were put forward.Methods The questionnaire of Adolescent Self-rating Life Events Check List(ASLEC)was distributed to 120 nursing students in each group through random sampling,and the SPSS 17.0 statistical software package was used for data analysis.Results The scores of Tibetan nursing students were higher than mainland nursing students on factors of study pressure,personal relationship and health adaptation,which showed significant difference.The results of ASLEC showed that the scores of personal relationship,deserved punishment and loss in the Tibetan nursing students of 1st gradewere significantly higher than those in the Mainland nursing students of 1st grade score.The scores of study pressure in the Tibetan nursing students of 2nd grade were significantly higher than those in the Mainland nursing students of 2nd grade.The scores of personal relationship and health adaptation in Tibetan nursing students of 3rd grade were higher than those in the Mainland Nursing Students of 3rd grade score.Conclusions Influence of stress to the life affairs on psyche of Tibetan nursing students is outstanding in contrast to Mainland nursing students,and Tibetan nursing students were given directed intervention of mental health problem according to their risk factors of stress to the life affairs.
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Objective To investigate the influencing factors of pain and the changes of vital signs in newborn infants. Methods Forty two newborn infants were rated by the behavioral scale of acute pain in newborn infants. The scores of pain were compared among infants with different gender,gestational age,birth weight,birth age,type of puncture and whether by vaginal birth or not. At the same time,the respiration rate,heart rate,blood pressure and oxygen saturation (SO2)were dynami-cally recorded by the multi-function monitor in the process of puncture. Results The average score of pain was 7.6. There was no significant difference among newborn infants with different gender,gestational age,birth weight and type of puncture(P> 0.05),while significant differences among infants with different birth age and whether by vaginal birth or not (P=0.015 and 0.043 respectively). In the process of puncture,the SO2 was significantly decreased,while the respiration rate,heart rate,sys-tolic and diastolic blood pressure were significantly increased. Conclusions Pain is prevalent in newborn infants and accom-panied by obvious changes of vital signs. The means of childbirth and birth age have significant influence on the neonatal pain. It is suggested to pay close attention to the neonatal pain and take effective interventions.
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Objective To discuss the meaning of the method of two-step pattern case teaching in image diagnostics. Methods The experiment group was taught by the two-step pattern case teaching,while the control group by the traditional method. Results The experiment group’s image diagnostics exam average score is higher than the control group’s,and the average scores of other major clinical courses are all higher. Conclusion The applications of the two-step pattern case teaching in medicine teaching is the need of developing the medical education business and improving the medical teaching quality.
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Objective To observe the vascular collagen remodeling, apoptosis and Bcl-2/Bax of vascular smooth muscle cells in carotid artery on SHR . Methods 12 SHR treated with Irbesartan ,12 SHR without treated Irbesartan ,12 wistar rats were normotensive control group. The vascular volume fraction of Collagen were determined by picrosirius red staining .The expression of the proteins Bcl-2 and Bax were determined by Immunhistochemia,VSMC apoptosis was identified by in situ TDT-mediated dUTP nick end labeling(TUNEL). Results Significant Fibrosis exists in carotid artery of SHR. After 20 week's treating, the vascular volume fraction of Collagen and the ratio of wall/cavity were descended, but weren't parallel. The expression of the protein Bcl-2 and APOI were higher than the subjects of normotensive control, its reduced after treating; The expression of the proteins Bax was similar with control, it increased after treating. Conclusions The results suggest that vascular collagen remodeling exist, its maybe related with apoptosis , the proteins Bcl-2 and Bax of VSMC. The Irbesartan can treat it.
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Objective To discuss the importance of the clinic skill learning center in diagnostics teaching.Methods The experiment group was taught in the clinic skill learning center with the reformed method,while the control group was taught in the traditional laboratories with the traditional one.Results The experiment group's two average scores of diagnostics and skill examine are higher than the control group's,and the difference between the two group's average scores are significant in the statistics analysis.Conclusion The applications of the clinical skill learning center in medicine teaching is the need of developing the medical education business and fostering standardized medical talents.
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[Objective] To observe the therapeutic effect of Shuangping San in treating mycoplasmal pneumonia (MP)in children. Shuangping San is a prescription composed of modified yupingfeng San, Sijiuzi Tang and Sini San, whichhas the actions of strengthening spleen and lung, replenishing Qi and consolidating exterior a11d soothing liver andregulating spleen. [Methods] Ninety-eight cases of MP were randomized into control group (n= 48) and treatmentgroup (n = 50). The control group was treated with erythromycin and the treatment group with erythromycin andShuangping San. Therapeutic effect, incidence of toxic and side reaction induced by erythromycin and incidence of post-infection spleen-deficiency syndrome were observed in the two groups. [ Results] Therapeutic effect was better,incidence of toxic and side reaction induced by erythromycin and incidence of post-infection spleen-deficiency syndromewere lower in the treatment group than those in the control group (P
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Objective To investigate the effect of Xuefuzhuyu granule combined Irbesartan in reversing the carotid vascular remodeling of essential hypertension(EH) patients. Methods 61 EH patients were enrolled in this study. 29 cases of EH were treated with Irbesartan, 32 cases were treated with Xuefuzhuyu granule and Irbesartan, and 28 normotensive subjects served as control. Color dopplor ultrasound were adopted to measure IMT and LD of carotid. Results After treated for 9～12 months, the IMT and IMT/LD in EH patietns treated by Xuefuzhuyu granule and Irbesartan significantly decreased than those in EH patients treated only by Irbesartan. Conclusion Xuefuzhuyu granule was beneficial to reversing the carotid vascular remodeling in EH patients.
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Objective To discuss the effect of ill performance characteristics of type A behavior pattern (TABP) in the attack and development of cerebral infarction(CI).Methods The 100 patients with CI and 107 control subjects without any blood disease or tumors were evaluated by applying the Chart of Typical Behaviors of TABP, meanwhile the endothelin (ET) and thrombomodulin(TM) contents in plasma of the patients were measured for the mark of the damage of blood vessel endothelium. The CI group, control groups and part of CI group with the same level of blood pressure were subgroup by the result of questionnaire, correlation analysis was made between the amounts of blood markers and ill performance characteristics of TABP. Results 40% CI patients were TABP. The amounts of ET [(89.78?2.15)ng/ml] and TM [(52.68?3.47)ng/ml]in the plasma of the CI patients with ill performance characteristics were not only obviously higher than those of the control group [ET(57.82?1.83)ng/ml];TM:[36.05?1.07)ng/ml], but also higher than that of part of CI patients without ill performance characteristics of TABP(all P