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1.
International Journal of Laboratory Medicine ; (12): 1297-1299, 2018.
Article in Chinese | WPRIM | ID: wpr-692835

ABSTRACT

Objective To explore the expression and significance of insulin grow th factor 1(IGF-1) and gli-al fibriuary acidic protein(GFAP) in patients with glioma .Methods The serum levels of IGF-1 and GFAP in 40 glioma patients ,30 healthy subjects and 35 patients with other benign intracranial tumors were measured by double antibody sandwich method .Results There was no significant difference in serum IGF-1 and GFAP lev-els between healthy subjects and other benign intracranial tumor patients (P>0 .05) ,and the levels of IGF-1 and GFAP in the serum of glioma patients were significantly higher than those of healthy and other benign in-tracranial tumor patients (P<0 .05) .The serum levels of IGF-1 and GFAP in glioma patients after operation were significantly lower than those before operation (P< 0 .05) .Conclusion The expression of IGF-1 and GFAP in the serum of glioma patients is significantly higher than those of healthy subjects and other benign intracranial tumor patients .It has good sensitivity and specificity .It can be used as a serum marker of glioma patients and has certain clinical value .

2.
Chinese Journal of Preventive Medicine ; (12): 421-426, 2017.
Article in Chinese | WPRIM | ID: wpr-808761

ABSTRACT

Objective@#To investigate the effect of polycyclic aromatic hydrocarbons (PAHs) exposure on the level of histone H3Ser10 phosphorylation (p-H3S10) and DNA damage degree in peripheral blood lymphocyte (PBLCs).@*Method@#75 coke oven workers from Benxi steel plant in Liaoning Province of China (PAHs-exposed group) and local 50 hot rolling workers (control group) were recruited in this study with age, working years, labor intensity and high temperature for matching factors using cluster sampling method in 2014. HPLC-fluorescence was performed to determine the level of urinary 1-hydroxypyrene (1-OHP), DNA damage and specific histone modification were measured in PBLCs of the subjects through comet assay and ELISA assay, respectively. Linear regression model analysis was used to analyze the differences among PAHs exposure, DNA damage and p-H3S10 level in two groups. The Mediation analysis was used to analyze the regulated relationships between urinary 1-OHP, DNA damage and histone modification through the bootstrap method.@*Results@#Age of the control and the exposed group were (45.32±8.32) and (43.87±5.67) years old (P=0.284). The concentration of urinary 1-OHP, OTM value, Tail DNA% and p-H3S10 level in exposure group were higher than that in control group, while the M (P5-P95) of p-H3S10 levels in control and exposed group were 2.21 (0.68-4.71), 4.54 (1.85-23.91) (P<0.001). The degree p-H3S10 level was increased after the subgroups which were (2.59±1.19)%, (3.24±2.81)%, (5.55±3.25)%, (8.77±7.84)%, respectively, divided by quantitated 1-OHP concentration as P0-P25, P26-P50, P51-P75 and P76-P100 (P<0.001). We also found the correlations between urinary 1-OHP and p-H3S10 level or OTM value or Tail DNA%, β (95%CI) were 0.264 (0.167-0.360), 0.500 (0.299-0.702), and 0.510 (0.384-0.671), respectively (P<0.001). Similar result was also observed between p-H3S10 level and OTM value or Tail DNA%, β (95%CI) were 0.149 (0.073-0.226) and 0.220 (0.132-0.308) (P<0.001). Moreover, the mediation effect value of DNA damage on PAHs induced p-H3S10 alteration was 0.054(P=0.040).@*Conclusion@#The results suggested that PAHs exposure could induce DNA damage and an increase in histone H3Ser10 phosphorylation in PBLCs. Particularly, the alteration of H3S10 phosphorylation may play an important role in regulating cell DNA damage repair.

3.
Chongqing Medicine ; (36): 1633-1634,1637, 2015.
Article in Chinese | WPRIM | ID: wpr-601896

ABSTRACT

Objective To explore the abnormal changeof the polysomnography(PSG) in the patientwith traumatifrontal lobe injury .MethodTotally 16 patientwith traumatifrontal lobe injury accompanying sleep disorde(brain traumgroup) and 20 individualof physical examination (control group) were performed the whole nighPSG .ResultCompared with the control group ,the incubative stage of sleep in the brain traumgroup waprolonged ,while the sleep time and slow wave sleep time were shortened .The rapid eye movemen(REM) time and the periodicity of REM had statistical differencebetween the two group,buthe REM incubative stage ,density and intensity of REM had no statistical differencebetween the two goup.Conclusion The changeof PSG in the patientwith traumatifrontal lobe injury are dominated by the extension of the REM time and the shorten-ing of REM periodicity .

4.
Chongqing Medicine ; (36): 1206-1207,1210, 2015.
Article in Chinese | WPRIM | ID: wpr-600437

ABSTRACT

Objective Research on traumatic the related factors of sleep disorder after traumatic brain injury ,in order to pro-vided the rationale for the diagnosis and treatment .Methods The SPIEGEL was used to evaluate the traumatic brain injury patients who were hospitalized .Recording time in sleep disorders in 3 months .Analysis the relations between the sleep disorders and brain injury site by combining with the patients head CT and MRI .Results Seen in 200 cases of patients with sleep disorders of 105 cases (52 .5% );71 cases appeared in patients within 1 week after waking ,accounted for 76 .19% ;The brain stem ,frontal lobe and basal ganglia injury occurred sleep disorders were more likely(66 .7% ,64 .0% ,70% ) .The difference was statistically significant(P<0 .05) .Conclusion Sleep disorder is a common clinical symptom of mild traumatic brain injury .a time to focus on the patients with-in 1 week after waking ,and closely related to brain stem ,frontal lobe and basal ganglia injury .

5.
Chinese Journal of Preventive Medicine ; (12): 840-843, 2015.
Article in Chinese | WPRIM | ID: wpr-269982

ABSTRACT

Benzene is classified as Group 1 carcinogen by IARC. It has been found that benzene induces hematotoxicity even in low dose exposure. The identification of key events during benzene induced hematotoxicty leads to adjustment of occupational exposure limits of benzene. In this review, we focus on the exposure, metabolism, target organs, key epigenetic changes, toxicty effects and end points of low-dose chronic benzene exposure induced hematotoxicity and finally discuss the perspectives on the future study of this area.


Subject(s)
Humans , Benzene , Toxicity , Carcinogens , Toxicity , Epigenesis, Genetic , Occupational Exposure
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