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Objective:To analyze the clinical characteristics and surgical treatment of patients with cervical bronchogenic cyst.Methods:This study enrolled 14 cases of cervical bronchogenic cysts confirmed by surgery and pathology in our hospital from Sep 2015 to Sep 2020 to discuss clinical, imaging features and diagnosist.Results:Cysts lay in the left neck in 8 cases and in the right side in 6 cases, with the largest diameter of 5.8 cm and the smallest of 0.8 cm (3.4±1.7) cm. Cysts were closely related to the thyroid in 10 cases, adjacent to the recurrent laryngeal nerve in 2 cases. The postoperative pathology established the diagnosis of bronchogenic cyst, and no patients suffered from recurrence during the follow-up period.Conclusions:Cervical bronchogenic cyst is a rare congenital malformation of extrathoracic bronchogenic cyst. Final diagnosis is dependent upon pathology. Complete surgical resection is the key to prevent recurrence.
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Objective:To evaluate the auxiliary role of the Python-based handover database in online teaching activities for medical clerks and to complete the teaching tasks during the COVID-19 epidemic.Method:Sixteen teachers were randomized into two groups, experimental group and control group, with 8 ones in each group. The experimental group used the self-built handover database, while the control group used the hospital's HIS system. To make multimedia courseware for medical students, suitable cases were screened. The time to acquire cases and picture data, and the index like numbers were statistically analyzed, and the quality of multimedia courseware was scored. All the data were analyzed by SPSS 25.0 statistical software.Results:The time for the two groups of teachers to acquire target cases during making multimedia coursewares were (8.88±3.48) min and (43.50±5.26) min respectively; the time to obtain the pictures were (5.62±1.92) min and (30.25±5.39) min; the numbers of obtained pictures were (11.12±2.17) and (6.12±2.80); and the scores of coursewares were (92.62 ± 4.93) points and (84.75 ± 6.20) points respectively, all with significant differences.Conclusion:The application of the self-made handover database can significantly improve the speed of teachers' access to related teaching data, and also can improve the quality of multimedia courseware.
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Objective@#To investigate and analyze the clinical teaching of residents standardized training in Zhejiang University, so as to provide references to improve the quality of residents standardized training.@*Methods@#Questionnaires were designed and electronic surveys via WJX software were conducted among residents from six affiliated hospitals of Zhejiang University School of Medicine on management, clinical teaching and assessment of residents. SPSS 19.0 was used to perform the χ2 test of relevant data.@*Results@#A total of 799 residents, including 312 males and 487 females, took part in this survey. In terms of satisfaction degree, trained residents had a relatively high satisfaction degree on training base (73.46%), satisfaction degrees of residents from Grade one, two and three were 69.05%, 74.72% and 79.30%, respectively. Satisfaction degree of residents with different identities to training base was social men (85.71%) > staff working in units (74.08%) > professional postgraduates (56.7%). In terms of teaching, 64.45% residents thought that clinical teachers spent 20% more time on the clinical teaching than on the daily routine work, 39.42% residents thought that clinical teachers spent 30% more and 18.52% residents thought clinical teachers spent 40% more. In addition, 70.47% residents responded that their teachers revised and instructed the medical history writing more than twice a week; 78.84% trained residents admitted that all teachers made full preparations for clinical teaching rounds. Besides, the process evaluation of training base was well implemented. Implementation rate of after-department examination and annual examination were 99.37% and 98.50%, respectively.@*Conclusion@#Residents of Zhejiang University have a high satisfaction degree on training management and clinical teaching. Homogenized management of training base should be strengthened, and evaluation and feedback should be stressed.
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Objective To investigate and analyze the clinical teaching of residents standardized training in Zhejiang University, so as to provide references to improve the quality of residents standardized training. Methods Questionnaires were designed and electronic surveys via WJX software were conducted among residents from six affiliated hospitals of Zhejiang University School of Medicine on management, clinical teaching and assessment of residents. SPSS 19.0 was used to perform the χ2 test of relevant data. Results A total of 799 residents, including 312 males and 487 females, took part in this survey. In terms of satisfaction degree, trained residents had a relatively high satisfaction degree on training base (73.46％), satisfaction degrees of residents from Grade one, two and three were 69.05％, 74.72％and 79.30％, respectively. Satisfaction degree of residents with different identities to training base was social men (85.71％) > staff working in units (74.08％) > professional postgraduates (56.7％). In terms of teaching, 64.45％ residents thought that clinical teachers spent 20％ more time on the clinical teaching than on the daily routine work, 39.42％ residents thought that clinical teachers spent 30％ more and 18.52％ residents thought clinical teachers spent 40％more. In addition, 70.47％residents responded that their teachers revised and instructed the medical history writing more than twice a week; 78.84％ trained residents admitted that all teachers made full preparations for clinical teaching rounds. Besides, the process evaluation of training base was well implemented. Implementation rate of after-department examination and annual examination were 99.37％and 98.50％, respectively. Conclusion Residents of Zhejiang University have a high satisfaction degree on training management and clinical teaching . Homogenized management of training base should be strengthened, and evaluation and feedback should be stressed.
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The liver plays an vital role in glucose and lipid metabolism,synthesis of plasma proteins,and detoxification of xenobiotics.Liver chronic disease is one of the leading causes of death in China.Liver mass can be restored by two mechanisms:division of hepatocytes and hepatic oval cells (HOCs) proliferation and differentiation.However,the origin,specific markers and signaling pathways of HOCs have not been fully elucidated.Recent researches in HOCs isolation methods and genetic lineage tracing have enabled investigators to study multiple aspects of HOCs origin and biology.We reviewed the previous researches in detail.
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Objective To compare and analyze the supply of blood collection and clinical blood demand in Hangzhou during 2011-2016,and to put forward some countermeasures and suggestions.Methods The related data of blood collection in blood center and the indexs of clinical blood demand in all hospitals in Hangzhou were collected during 2011-2016,and the growth rates of both of them were compared and analyzed.Results 1) The data of blood collection and supply was the lowest in 2012,and then increased year by year.The average annual growth of platelet collection and supply was 8.09％ and 8.47％,respectively,and the other indicators grew relatively gently.In 2016,the rate of blood donation reached 18.28 per thousand people.At the same period,the number of staff in institutions was basically stable.2) During 2011-2016,the blood demand of all hospitals in Hangzhoa maintained rapid growth.In Hangzhou,the number of hospitals increased by 10.65％ annually,and until 2016,there was an increase of 65.87％ over 2011.The average annual growth of the number of beds,the number of emergency patients and the number of inpatients increased by 10.21％,6.09％ and 11.40％ respectively.The growth rate of number of inpatients was higher than that of outpatient and emergency departments.Hospital employees remained at an average annual growth rate of nearly 10％.3) The clinical demand for blood increased significantly more higher than the growth of blood collection and supply.Conclusion Speed up the pace of the construction of blood supply,and keep pace with the construction of hospitals.Strengthening the publicity,health education and promotion models,in order to encourage more people,who are eligible for blood donation,to join the blood donation.And also strengthening personnel team building,improving overall work efficiency and level.
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Acanthopanax senticosus, a traditional herb commonly found in Northeastern Asia, has been used for treating neurodegenerative diseases. However, the molecular and cellular mechanisms of its effect on neuroinflammation have not been investigated. In the current study, quantitative proteomics approach was applied to investigate the effect of Acanthopanax senticosus extract [ASE] on nitrosative stress and inflammatory response in BV-2 microglial cells stimulated with lipopolysaccharide [LPS]. The results showed ASE inhibited LPS-induced nitric oxide [NO] production, while no significant toxicity appeared in the cells. Proteomic quantitative analyses using 2D-DIGE [Difference in Gel Electrophoresis] combined with liquid chromatography-electrospray ionization tandem mass spectrometry [LC-ESIMS/MS] revealed that 17 proteins showed significant changes responding to ASE. Furthermore, signal transduction pathways and network modulated by the ASE were predicted using Ingenuity Pathway Analysis [IPA]. These findings indicated the ability of ASE to suppress LPS-induced nitrosative stress in BV-2 cells, and may provide important insights into the molecular mechanism underlying potentially beneficial effect of Acanthopanax senticosus
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Naturally existing alpha -glucosidase inhibitors from traditional herbal medicines have attracted considerable interest to treat type 2 diabetes mellitus [T2DM]. Hundreds of herbs have been reported to have the potential to inhibit alpha - glucosidase. However, most common methods to examine the inhibitors of alpha -glucosidase are usually time-consuming. In the current study, the screening of alpha -glucosidase ligands from Coptis chinensis Franch extract was undertaken by ultrafiltration liquid chromatography coupled to electrospray ionization tandem mass spectrometry [ultrafiltration LCESI-MS[n]]. Resultantly, the enzyme inhibition studies showed that Coptis chinensis Franch extract carries the strongest alpha - glucosidase inhibitory activity among the five kinds of Chinese herbal extracts. Subsequently, five compounds that could bind to alpha -glucosidase in the Coptis chinensis Franch extract were found using ultrafiltration liquid chromatography, and their structures were identified by ESI-MS[n] to be coptisine, epiberberine, jatrorrhizine, berberine, palmatine. Cumulatively, these results were anticipated to be encouraging for applying the Coptis chinensis Franch extracts as efficient anti-diabetic drug candidates
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Objective To evaluate the changes of left ventricular(LV) 3-dimension peak displacement (3D-D) during different cardiac pacing patterns. To provide a reliable mechanical data base for the optimization cardiac pacing. Methods Cardiac pacings in open-chest Beagle canine models( n = 10) were performed using three patterns[I, e. , right ventricular apical pacing (RVA-P), LV lateral pacing (LVL-P)and LV apical pacing(LVA-P)],3D full volumetric real-time imaging were acquired in a completed cardiac cycle. The 3D-D,3D-D peak time (3D-DTc) and the standard deviation of TC(3D-DTSD) were calculated and analyzed in different pacing patterns for difference and spatial correlationship. Results ① The 3D-D of LVL-P and LVA-P state decreased compared with BASE and RVA-P state, there were significant 3D-D difference of mid anterior,mid anteriorspetal, mid interior,mid posterior, mid lateral between LVL-P and BASE, RVA-P patterns( P ＜0.05). There were significant 3D-D difference of mid anterior,mid lateral,mid posterior between LVA-P and RVA-P patterns groups( P ＜0.05). There were significant 3D-D difference of all segments in apical level between LVL-P,LVA-P and BASE, RVA-P states( P ＜0.05). ② Corrected by the heart rate,the 3D-DTC of different cardiac pacing patterns were shorter than BASE state. ③ There were no significant 3D-DTSD difference between different cardiac pacings and BASE patterns. There were significant 3D-DTSD difference between RVA-P and LVA-P patterns (P ＜ 0.05). Conclusions LV mechanical activation and synchronization could be maintained during RVA-P rather than LVA-P and LVL-P. Echocardiographic study of left ventricular 3D-D can actually reveal myocardial mechanical state during different cardiac pacings and BASE patterns.